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Total 119356 results found since Jan 2013.
Longitudinal lipidomic signature of carotid atherosclerosis in American Indians: Findings from the Strong Heart Family Study
CONCLUSIONS: Baseline and longitudinal changes in multiple lipid species were significantly associated with carotid atherosclerosis and its progression in American Indians. Some plaque-related lipid species were also associated with risk for CVD events.PMID:37722315 | DOI:10.1016/j.atherosclerosis.2023.117265
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Guanhong Miao Oliver Fiehn Mingjing Chen Ying Zhang Jason G Umans Elisa T Lee Barbara V Howard Mary J Roman Richard B Devereux Jinying Zhao Source Type: research
Cardiovascular Risk Factors and Culprit Plaque Characteristics in Women With Acute Coronary Syndromes
In conclusion, early treatment of risk factors such as diabetes in young women might be important before accelerated progression of atherosclerosis begins as age advances. Clinical trial registration: http://www.clinicaltrials.gov, NCT01110538, NCT03479723 and NCT02041650.PMID:37722196 | DOI:10.1016/j.amjcard.2023.08.152
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Lena Marie Seegers Doreen DeFaria Yeh Malissa J Wood Taishi Yonetsu Yoshiyasu Minami Makoto Araki Akihiro Nakajima Haruhito Yuki Junya Ako Tsunenari Soeda Osamu Kurihara Takumi Higuma Shigeki Kimura Tom Adriaenssens Holger M Nef Hang Lee Iris McNulty Tomo Source Type: research
The mechanism of Plantaginis Semen in the treatment of diabetic nephropathy based on network pharmacology and molecular docking technology
CONCLUSION: PS can have the treatment on DN through CASP3. Quercetin, as one of the nine active ingredients, can be bounded to CASP3 to inhibit apoptosis in DN. PS can also take action on DN probably through many pathways. The role of PS on DN through other pathways still needs to be further elaborated.PMID:37718520 | DOI:10.2174/1871530323666230915100355
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Linlin He Kai Shen Lei He Yuqing Chen Zhiyuan Tang Source Type: research
Exploration of the anti-diabetic potential of hydro-ethanolic leaf extract of Koenigia polystachya L.: an edible wild plant from Northeastern India
CONCLUSIONS: Based on the outcomes of this study, the HELeKP-treated rats have significant free radical scavenging and anti-diabetic potential. Therefore, it can be recommended as a beneficial functional vegetable for consumption.PMID:37723570 | PMC:PMC10506326 | DOI:10.1186/s42826-023-00174-3
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Alokali Kiba Dipankar Saha Bhrigu Kumar Das Source Type: research
Physiological Activities of the King of Bitters (Andrographis paniculata): A Review
Cureus. 2023 Aug 15;15(8):e43515. doi: 10.7759/cureus.43515. eCollection 2023 Aug.ABSTRACTAndrographis paniculata is a versatile tropical plant that is considered to have many essential medicinal properties. Plants can combine an open scope of the natural active compound that carries out significant organic roles and are used as pharmaceuticals. Herbal plants have therapeutic and prophylactic properties, so scientists are concentrating on developing crude drugs to make people's lives easier. Medicinal plants are the primary sources of therapeutic remedies for various ailments. These potential medicinal effects are primaril...
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Sweza Bhaisare Swanand Pathak Vaishnavi V Ajankar Source Type: research
Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing
CONCLUSIONS: The Cu-CPNs@EPL complex has impressive antioxidant properties and antibacterial effects, making it a promising solution for treating drug-resistant bacterial infections in chronic wounds. The complex's ability to neutralize multiple ROS and reduce ROS-induced inflammation can help relieve inflammation at the wound site. Schematic illustration of the ROS scavenging and bacteriostatic function induced by Cu-CPNs@EPL nanozyme in the treatment of MRSA-infected wounds.PMID:37723499 | PMC:PMC10506277 | DOI:10.1186/s40824-023-00429-z
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Jiahui Zhao Tengfei Xu Jichao Sun Haitao Yuan Mengyun Hou Zhijie Li Jigang Wang Zhen Liang Source Type: research
Clinical and Epidemiological Profile of Herpes Zoster and Its Complications in a Tertiary Care Center of Bihar: A Prospective Study
Conclusion A broader understanding of the clinical and epidemiological factors of herpes zoster and post-herpetic complications is important as this disease constitutes a considerable burden in a tertiary care center and if not treated adequately, the after-effects might last for many years altogether. Hence, early diagnosis and initiation of adequate antiviral therapy as well as pain management is the key aspect of management.PMID:37719532 | PMC:PMC10503883 | DOI:10.7759/cureus.43560
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Rajesh Sinha Pinki Kumari U K Pallavi Subhasree Sarkar Source Type: research
Resveratrol ameliorates diabetic encephalopathy through PDE4D/PKA/Drp1 signaling
This study illustrated the role of PDE4D in DE and investigated whether resveratrol protected against DE via inhibiting PDE4D. db/db male mice and hippocampus cell line (HT22) were used to investigate the role of PDE4D and the protective effect of resveratrol on cognitive function under high glucose (HG). PDE4D overexpression or knockdown lentivirus and PKA specific inhibitor H89 were used to further identify the indispensable role of PDE4D/PKA signaling pathway in resveratrol's amelioration effect of neurotoxicity. Resveratrol attenuated cognitive impairment in db/db mice, reduced PDE4D protein, restored the impaired mito...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Yanjuan Cao Wen Sun Chang Liu Zihui Zhou Zongli Deng Mingjie Zhang Meng Yan Xiaoxing Yin Xia Zhu Source Type: research
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Interrelationship of hemoglobin A1c level lipid profile, uric acid, C-reactive protein levels and age in a large hospital database
CONCLUSION: At population level, HbA1c levels can be estimated almost exactly based on lipid profile, CRP and uric acid levels in female patients between 20 and 70 years.PMID:37722548 | DOI:10.1016/j.mcp.2023.101933
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Dlovan Ali Jalal Barna V ásárhelyi B éla Blaha Zolt án Tóth Tam ás Géza Szabó B éla Gyarmati Source Type: research
Resveratrol ameliorates diabetic encephalopathy through PDE4D/PKA/Drp1 signaling
This study illustrated the role of PDE4D in DE and investigated whether resveratrol protected against DE via inhibiting PDE4D. db/db male mice and hippocampus cell line (HT22) were used to investigate the role of PDE4D and the protective effect of resveratrol on cognitive function under high glucose (HG). PDE4D overexpression or knockdown lentivirus and PKA specific inhibitor H89 were used to further identify the indispensable role of PDE4D/PKA signaling pathway in resveratrol's amelioration effect of neurotoxicity. Resveratrol attenuated cognitive impairment in db/db mice, reduced PDE4D protein, restored the impaired mito...
Source: Brain Research - September 18, 2023 Category: Neurology Authors: Yanjuan Cao Wen Sun Chang Liu Zihui Zhou Zongli Deng Mingjie Zhang Meng Yan Xiaoxing Yin Xia Zhu Source Type: research
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor- κB and platelet aggregation in type 2 diabetic patients
In conclusion, restoring normal levels of vitamin D is an important determinant to maintain normal platelet function and reduce inflammation. Nevertheless, further long-term studies are still needed.PMID:37721213 | DOI:10.1139/cjpp-2022-0359
Source: Canadian Journal of Physiology and Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Esraa Habiba Samia Ali Yehia Ghanem Ola Sharaki Wafaa Hewedy Source Type: research
Moderate and high-intensity interval training protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats
Immunobiology. 2023 Sep 13;228(6):152745. doi: 10.1016/j.imbio.2023.152745. Online ahead of print.ABSTRACTDiabetes Mellitus (DM) can damage the function of metabolic tissues, including the liver. Liver macrophages are the first responders to tissue damage or exercise. We sought to determine whether eight weeks of interval training (HIIT & MIIT) protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats. Thirty rats were divided into six groups, including a control group, MIIT, HIIT, DM, DM + MIIT, and DM + HIIT (n = 5 ...
Source: Immunobiology - September 18, 2023 Category: Allergy & Immunology Authors: Reza Sheikh Saeid Shakerian Seyed Reza Fatemi Tabatabaei Abdolhamid Habibi Source Type: research
Resveratrol ameliorates diabetic encephalopathy through PDE4D/PKA/Drp1 signaling
This study illustrated the role of PDE4D in DE and investigated whether resveratrol protected against DE via inhibiting PDE4D. db/db male mice and hippocampus cell line (HT22) were used to investigate the role of PDE4D and the protective effect of resveratrol on cognitive function under high glucose (HG). PDE4D overexpression or knockdown lentivirus and PKA specific inhibitor H89 were used to further identify the indispensable role of PDE4D/PKA signaling pathway in resveratrol's amelioration effect of neurotoxicity. Resveratrol attenuated cognitive impairment in db/db mice, reduced PDE4D protein, restored the impaired mito...
Source: Brain Research Bulletin - September 18, 2023 Category: Neurology Authors: Yanjuan Cao Wen Sun Chang Liu Zihui Zhou Zongli Deng Mingjie Zhang Meng Yan Xiaoxing Yin Xia Zhu Source Type: research
The mechanism of Plantaginis Semen in the treatment of diabetic nephropathy based on network pharmacology and molecular docking technology
CONCLUSION: PS can have the treatment on DN through CASP3. Quercetin, as one of the nine active ingredients, can be bounded to CASP3 to inhibit apoptosis in DN. PS can also take action on DN probably through many pathways. The role of PS on DN through other pathways still needs to be further elaborated.PMID:37718520 | DOI:10.2174/1871530323666230915100355
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 18, 2023 Category: Endocrinology Authors: Linlin He Kai Shen Lei He Yuqing Chen Zhiyuan Tang Source Type: research
