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Condition: Diabetes
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How online peer support affects management efficacy and mitigates difficulties of parents caring for children with type 1 diabetes
Prim Care Diabetes. 2023 Sep 18:S1751-9918(23)00162-6. doi: 10.1016/j.pcd.2023.09.003. Online ahead of print.ABSTRACTThe proper management of pediatric type 1 diabetes depends substantially on the parents of affected children. Parental psychological traits specifically related to diabetes caregiving influence the quality of their care and management of the disease in their children. Parents often use Facebook groups as sources of peer support and information about diabetes care. The present study aimed to examine the influence of devices used in diabetes management, ascertain the impact of Facebook peer-support groups on p...
Source: Primary Care - September 20, 2023 Category: Primary Care Authors: Norbert Buz ás M ária Dóra Horváth Zsanett Tesch Emese Hallgat ó Source Type: research
Novel homozygous leptin receptor mutation in an infant with monogenic obesity
We report the case of a 12-month-old male infant born of a non-consanguineous marriage. He presented to us with rapid weight gain from 2 months of age along with hyperphagia. Biochemistry revealed a deranged lipid profile, elevated transaminases, and markedly raised serum leptin levels. On genetic analysis, a novel mutation was detected, which was a homozygous variation In exon 12 of the LEPR gene (chr1:g.65608901G>A) that resulted in the synonymous amino acid change of lysine at codon 584 proximal to donor splice site (p.Lys584). The in silico prediction of the variant was 'damaging' by MutationTaster2. The mutation wa...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Hiya Boro Vikash Bundela Velmurugan Mannar Lakshmi Nagendra Vinita Jain Bimal Jain Senthil Kumar Sourabh Agstam Source Type: research
Effect of Zuo's warming Yang acupuncture therapy combined with lifestyle interventions on prediabetes: A randomized controlled trial
CONCLUSIONS: Zuo's warming Yang acupuncture therapy conjunction with lifestyle interventions was more effective than lifestyle interventions alone in reducing FPG, 2hPG and HbA1c levels in prediabetic patients. These results suggest that Zuo's warming Yang acupuncture therapy may be a safe and effective treatment option for prediabetes.PMID:37730092 | DOI:10.1016/j.ctim.2023.102985
Source: Complementary Therapies in Medicine - September 20, 2023 Category: Complementary Medicine Authors: Yang Li Kehang Xie Xuanli Zeng Lu Ding Yuting Wang Liming Lu Changbo Zuo Source Type: research
In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices
This article aims to establish the protocols and demonstrate a few examples of in vitro oxygen imaging of BAP devices using EPROI. All pO2 measurements were performed using a recently introduced 720 MHz/25 mT preclinical oxygen imager instrument, JIVA-25™. We began by performing pO2 calibration of the biomaterials used in BAPs at 25 mT magnetic field since no such data exist. We compared the EPROI pO2 measurement with a single-point probe for a few selected materials. We also performed trityl OX071 toxicity studies with fibroblasts, as well as insulin-producing cells (beta TC6, MIN6, and human islet cells). Finally, we p...
Source: Cancer Control - September 20, 2023 Category: Cancer & Oncology Authors: Mrignayani Kotecha Longhai Wang Safa Hameed Navin Viswakarma Minglin Ma Cherie Stabler Corinne A Hoesli Boris Epel Source Type: research
Endoplasmic Reticulum Stress in Pancreatic β-Cells Induces Incretin Desensitization and β-Cell Dysfunction via ATF4-Mediated PDE4D Expression
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00156.2023. Online ahead of print.ABSTRACTPancreatic β-cell dysfunction and eventual loss are key steps in the progression of type 2 diabetes (T2D). Endoplasmic reticulum (ER) stress responses, especially those mediated by the PERK-ATF4 pathway, have been implicated in promoting these β-cell pathologies. However, the exact molecular events surrounding the role of the PERK-ATF4 pathway in β-cell dysfunction remain unknown. Here, we report our discovery that ATF4 promotes the expression of PDE4D, which disrupts β-cell function via a downregulation of cAMP s...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Ji-Hye Lee Hanguk Ryu Hyejin Lee Hye Ram Yu Yurong Gao Kyeong-Min Lee Young-Joon Kim Jaemin Lee Source Type: research
Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects
Biomed Pharmacother. 2023 Sep 18;167:115519. doi: 10.1016/j.biopha.2023.115519. Online ahead of print.ABSTRACTProtein acetylation modifications play a central and pivotal role in a myriad of biological processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and beyond, by effectively reshaping protein structure and function. The metabolic state of cells is intricately connected to epigenetic modifications, which in turn influence chromatin status and gene expression patterns. Notably, pathological alterations in protein acetylation modifications are frequently observed in diseases such as metabo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Nan Jiang Wenyong Li Shuanglin Jiang Ming Xie Ran Liu Source Type: research
Role of the tripartite motif-containing (TRIM) family of proteins in insulin resistance and related disorders
Diabetes Obes Metab. 2023 Sep 19. doi: 10.1111/dom.15294. Online ahead of print.ABSTRACTEmerging evidence suggests that the ubiquitin-mediated degradation of insulin-signalling-related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif-containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein levels and function by ubiquitination, which is essential for the modulation of insulin sensitivity. Recent research has indicated that some of these TRIMs act as key regulatory factors of metabolic disorders such as ty...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Jianrong Chen Xianjie Feng Xu Zhou Yong Li Source Type: research
Road map for personalized exercise medicine in T2DM
Trends Endocrinol Metab. 2023 Sep 18:S1043-2760(23)00166-2. doi: 10.1016/j.tem.2023.08.013. Online ahead of print.ABSTRACTThe number of patients with type 2 diabetes mellitus (T2DM) is rising at an alarming rate. Regular physical activity and exercise are cornerstones in the therapy of T2DM. While a one-size-fits-all approach fails to account for many between-subject differences, the use of personalized exercise medicine has the potential of optimizing health outcomes. Here, a road map for personalized exercise therapy targeted at patients with T2DM is presented. It considers secondary complications, glucose management, re...
Source: Trends in Endocrinology and Metabolism: TEM - September 20, 2023 Category: Endocrinology Authors: Christian Brinkmann Source Type: research
24-year-old woman • large joint arthralgias • history of type 1 diabetes, seizures, migraines • Dx?
J Fam Pract. 2023 Sep;72(7):E30-E32. doi: 10.12788/jfp.0651.ABSTRACT► large joint arthralgias ► history of type 1 diabetes, seizures, migraines.PMID:37729147 | DOI:10.12788/jfp.0651
Source: The Journal of Family Practice - September 20, 2023 Category: Practice Management Authors: Asher George Stephen Rayborn Peyton Herrington Svenja Albrecht Adrian Billings Source Type: research
Is low-dose naltrexone effective in chronic pain management?
J Fam Pract. 2023 Sep;72(7):320-321. doi: 10.12788/jfp.0654.ABSTRACTYES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT]). Low-dose naltrexone significantly reduced pain by 32% in inflammatory conditions and 44% in neuropathic conditions (SOR, B; single retrospective cohort study). Doses as low as 5.4 mg were found to reduce pain in 95% of patients with fibromyalgia (SOR, B; single prospective dose-response study).PMID:37729143 | DOI:10.12788/jfp.0654
Source: The Journal of Family Practice - September 20, 2023 Category: Practice Management Authors: Roxanne Radi Harriet Huang Jason Rivera Corey Lyon Kristen DeSanto Source Type: research
Diabetes Mellitus Drug Discovery: Insights into Targeting Feline and Human Amylin with Small Molecules
Vet Q. 2023 Sep 20:1-20. doi: 10.1080/01652176.2023.2260442. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is a health concern for both humans and cats, with cases rising over the past decade. Around 70% of patients from either species exhibit pancreatic aggregates of islet amyloid polypeptide (IAPP), a protein that proves toxic upon misfolding. These misfolded protein aggregates congregate in the islets of Langerhans of the pancreas, diminishing the capability of β-cells to produce insulin and further perpetuating disease. Our team's drug discovery program is investigating newly synthesized compounds that could dim...
Source: Veterinary Quarterly - September 20, 2023 Category: Veterinary Research Authors: Kendall B E Moore Natalie G Horgan Brooke Lenters Jessica S Fortin Source Type: research
Association of participants who screened positive for night eating syndrome with physical health, sleep problems, and weight status in an Australian adult population
CONCLUSIONS: Several physical health problems were found to be significantly associated with the spNES group including sleep problems, increased BMI, increased levels of pain and lower self-reported physical health-related quality of life. Consequently, future research exploring the complex interaction between NES and these medical conditions may provide further insight into the diagnosis, screening tools and management of NES. Additionally, this study highlights the need for future studies which use larger population-based samples.LEVEL OF EVIDENCE: Level III. Evidence obtained from well-designed cohort or case-control an...
Source: Eating and weight disorders : EWD - September 20, 2023 Category: Eating Disorders & Weight Management Authors: Sai Janani Sakthivel Phillipa Hay Stephen Touyz David Currow Haider Mannan Source Type: research
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
In this study, we found that SIRT1 is closely related to expression of GLP-1R in hippocampus of 3xTg mice. Therefore, we used semaglutide, a novel GLP-1R agonist currently undergoing two phase 3 clinical trials in AD patients, to observe the effect of SIRT1 after semaglutide treatment in 3XTg mice and HT22 cells, and to explore the mechanism of SIRT1 in the glucose metabolism disorders of AD. The mice were injected with semaglutide on alternate days for 30 days, followed by behavioral experiments including open field test, new object recognition test, and Y-maze. The content of glucose in the brain was also measured by usi...
Source: Neuropharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: Zhao-Jun Wang Xin-Ru Li Shi-Fan Chai Wei-Ran Li Shuo Li Meng Hou Jia-Lei Li Yu-Cai Ye Hong-Yan Cai Christian H ölscher Mei-Na Wu Source Type: research
Mechanisms of action of incretin receptor based dual- and tri-agonists in pancreatic islets
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00236.2023. Online ahead of print.ABSTRACTSimultaneous activation of the incretin G protein coupled receptors via unimolecular dual-receptor agonists (UDRA) has emerged as a new therapeutic approach for type 2 diabetes. Recent studies also advocate triple agonism with molecules also capable of binding the glucagon receptor. In this scoping review we discuss the cellular mechanisms of action (MOA) underlying the actions of these novel and therapeutically important classes of peptide receptor agonists. Clinical efficacy studies of several UDRAs have demonstrate...
Source: Am J Physiol Endocri... - September 20, 2023 Category: Endocrinology Authors: Franco Folli Giovanna Finzi Roberto Manfrini Alessandra Galli Francesca Casiraghi Lucia Centofanti Cesare Berra Paolo Fiorina Alberto Davalli Stefano La Rosa Carla Perego Paul B Higgins Source Type: research
Endoplasmic Reticulum Stress in Pancreatic β-Cells Induces Incretin Desensitization and β-Cell Dysfunction via ATF4-Mediated PDE4D Expression
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00156.2023. Online ahead of print.ABSTRACTPancreatic β-cell dysfunction and eventual loss are key steps in the progression of type 2 diabetes (T2D). Endoplasmic reticulum (ER) stress responses, especially those mediated by the PERK-ATF4 pathway, have been implicated in promoting these β-cell pathologies. However, the exact molecular events surrounding the role of the PERK-ATF4 pathway in β-cell dysfunction remain unknown. Here, we report our discovery that ATF4 promotes the expression of PDE4D, which disrupts β-cell function via a downregulation of cAMP s...
Source: Am J Physiol Endocri... - September 20, 2023 Category: Endocrinology Authors: Ji-Hye Lee Hanguk Ryu Hyejin Lee Hye Ram Yu Yurong Gao Kyeong-Min Lee Young-Joon Kim Jaemin Lee Source Type: research
