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Condition: Stroke
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The Piano Man: A Case Report of Anterior Thalamic Infarct with Dementia and Preserved Music Ability
CONCLUSIONS: The case has implications for understanding the complex integrative functions of the thalamus, including how profound impairment can simultaneously present with cognitive strengths that may not be captured by performance on neuropsychological testing. This case also suggests that magnetic resonance imaging may be indicated in cases presenting with vascular risk factors and sudden onset cognitive impairment, given that computed tomography may not be sensitive to small subcortical infarcts.PMID:37699427 | DOI:10.1093/arclin/acad069
Source: Archives of Clinical Neuropsychology - September 12, 2023 Category: Psychiatry & Psychology Authors: Ashleigh F Parker Theone S E Paterson Tamara Goranson Jodie R Gawryluk Source Type: research
Coating-Free Culture Medium for Establishing and Maintaining Human Induced Pluripotent Stem Cells
In this study, we develop an innovative coating-free medium for expanding hPSCs. The xenofree medium supports the weekend-free culture and competitive growth of hPSCs on several cell culture plastics without an additional pre-coating process. The pluripotent stemness of the expanded cells is stably sustained for more than 10 passages, featured with high pluripotent marker expressions, normal karyotyping, and differentiating capacity for three germ layers. The expression levels of some integrins are reduced, compared with those of the hPSCs on Matrigel. This medium also successfully supports the clonal expansion and induced...
Source: Cell Transplantation - September 12, 2023 Category: Cytology Authors: Chih-Yao Lin Yu-Yun Ching Shih-Fang Wu Yi-Ko Lee Hueng-Chuen Fan Liang-Yu Su Su-Yi Tsai Yu-Ching Chen Ching-I Shen Hong-Lin Su Source Type: research
Implementation of Prevention Science to Eliminate Health Care Inequities in Achieving Cardiovascular Health: A Scientific Statement From the American Heart Association
Circulation. 2023 Sep 12. doi: 10.1161/CIR.0000000000001171. Online ahead of print.ABSTRACTPrevention of cardiovascular and related diseases is foundational to attaining ideal cardiovascular health to improve the overall health and well-being of individuals and communities. Social determinants of health and health care inequities adversely affect ideal cardiovascular health and prevention of disease. Achieving optimal cardiovascular health in an effective and equitable manner requires a coordinated multidisciplinary and multilayered approach. In this scientific statement, we examine barriers to ideal cardiovascular health ...
Source: Circulation - September 12, 2023 Category: Cardiology Authors: Anandita Agarwala Jaideep Patel Janna Stephens Shamarial Roberson Jewel Scott Theresa Beckie Elizabeth A Jackson American Heart Association Prevention Science Committee of the Council on Epidemiology and Prevention and Council on Cardiovascular and Stroke Source Type: research
Word Repetition Paired With Startling Stimuli Decreases Aphasia and Apraxia Severity in Severe-to-Moderate Stroke: A Stratified, Single-Blind, Randomized, Phase 1 Clinical Trial
CONCLUSIONS: This study is the first to evaluate the impact of training with startling acoustic stimuli on clinical measures of aphasia and AOS. Our findings suggest START can enhance both nontrained speech production and receptive speech tasks in moderate/severe aphasia, possibly by reducing poststroke cortical inhibition. Our findings should be considered carefully, as our limitations include small effect sizes, within-group variability, and low completion rates for quality-of-life assessments and follow-up visits. Future studies should explore a mechanism of action, conduct larger and longer Phase 2 clinical trials, and...
Source: American Journal of Speech-Language Pathology - September 12, 2023 Category: Speech-Language Pathology Authors: Zoe Swann Nathan Tesman Corianne Rogalsky Claire F Honeycutt Source Type: research
Vitamin E supplementation (alone or with other antioxidants) and stroke: a meta-analysis
CONCLUSIONS: Supplementation with vitamin E alone is not associated with stroke reduction. Instead, supplementation of vitamin E with other antioxidants reduces the incidence of ischemic stroke but increases the risk of hemorrhagic stroke, cancelling any beneficial effect derived. Thus, vitamin E is not recommended in stroke prevention.SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42022258259.PMID:37698992 | DOI:10.1093/nutrit/nuad114
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Enrico Maggio Valeria Proietti Bocchini Roberto Carnevale Pasquale Pignatelli Francesco Violi Lorenzo Loffredo Source Type: research
Stimulator of interferon genes (STING): Key therapeutic targets in ischemia/reperfusion injury
Biomed Pharmacother. 2023 Sep 10;167:115458. doi: 10.1016/j.biopha.2023.115458. Online ahead of print.ABSTRACTThe Stimulator of Interferon Genes (STING) is predominantly expressed in immune cells, including macrophages, natural killer cells, dendritic cells, and T cells, functioning as a pattern recognition receptor. STING activation upon detecting cytosolic DNA released from damaged cells initiates downstream pathways, leading to the production of inflammatory cytokines such as IFNs, IL-6, and TNF-α. Dysregulated STING activation has been implicated in inflammatory and metabolic diseases. Ischemia/reperfusion injury (I/R...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 12, 2023 Category: Drugs & Pharmacology Authors: Juan Lv Xuanxuan Zhu Chunlei Xing Yuhong Chen Huihui Bian Heng Yin Xiaofeng Gu Li Su Source Type: research
Implementation of Prevention Science to Eliminate Health Care Inequities in Achieving Cardiovascular Health: A Scientific Statement From the American Heart Association
Circulation. 2023 Sep 12. doi: 10.1161/CIR.0000000000001171. Online ahead of print.ABSTRACTPrevention of cardiovascular and related diseases is foundational to attaining ideal cardiovascular health to improve the overall health and well-being of individuals and communities. Social determinants of health and health care inequities adversely affect ideal cardiovascular health and prevention of disease. Achieving optimal cardiovascular health in an effective and equitable manner requires a coordinated multidisciplinary and multilayered approach. In this scientific statement, we examine barriers to ideal cardiovascular health ...
Source: Circulation - September 12, 2023 Category: Cardiology Authors: Anandita Agarwala Jaideep Patel Janna Stephens Shamarial Roberson Jewel Scott Theresa Beckie Elizabeth A Jackson American Heart Association Prevention Science Committee of the Council on Epidemiology and Prevention and Council on Cardiovascular and Stroke Source Type: research
Artificial intelligence-based preventive, personalized and precision medicine for cardiovascular disease/stroke risk assessment in rheumatoid arthritis patients: a narrative review
AbstractThe challenges associated with diagnosing and treating cardiovascular disease (CVD)/Stroke in Rheumatoid arthritis (RA) arise from the delayed onset of symptoms. Existing clinical risk scores are inadequate in predicting cardiac events, and conventional risk factors alone do not accurately classify many individuals at risk. Several CVD biomarkers consider the multiple pathways involved in the development of atherosclerosis, which is the primary cause of CVD/Stroke in RA. To enhance the accuracy of CVD/Stroke risk assessment in the RA framework, a proposed approach involves combining genomic-based biomarkers (GBBM) ...
Source: Rheumatology International - September 11, 2023 Category: Rheumatology Source Type: research
Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen-glucose deprivation condition
CONCLUSIONS: Together, this study revealed the protection of VPA in ex vivo OGD-induced pathological form of neuroplasticity and in vivo PTI-induced brain damage and motor dysfunction through rescuing GABAergic deficiency and the pathological hallmarks of ischemia.PMID:37695500 | DOI:10.1007/s43440-023-00525-w
Source: Pharmacological Reports - September 11, 2023 Category: Drugs & Pharmacology Authors: Ming-Chia Chu Wei-Chang Mao Han-Fang Wu Yun-Chi Chang Ting-I Lu Chi-Wei Lee Yueh-Jung Chung Tsung-Han Hsieh Hsun-Shuo Chang Yih-Fung Chen Chia-Hsien Lin Chih-Wei Tang Hui-Ching Lin Source Type: research
Role of Vitamins in Cardiovascular Health: Know Your Facts-Part 2
Curr Vasc Pharmacol. 2023 Sep 11. doi: 10.2174/1570161121666230911115725. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is a major cause of morbidity/mortality world-wide, hence preventive interventions are crucial. Observational data showing beneficial CV-effects of vitamin supplements, promoted by self-proclaimed experts, have led to ~50% of Americans using multivitamins; this practice has culminated into a multi-billion-dollar business. However, robust evidence is lacking, and certain vitamins might incur harm. This two-part review focuses on the attributes or concerns about specific vitamin consumption on ...
Source: Current Vascular Pharmacology - September 11, 2023 Category: Drugs & Pharmacology Authors: Antonis A Manolis Theodora A Manolis Helen Melita Antonis S Manolis Source Type: research
Herpesvirus latent infection promotes stroke via activating the OTUD1/NF- κB signaling pathway
CONCLUSION: Herpes virus latent infection promotes cerebral infarction by activating the OTUD1/NF-κB signaling pathway.PMID:37695739 | DOI:10.18632/aging.205011
Source: Herpes - September 11, 2023 Category: Infectious Diseases Authors: Jiacai Lin Yangrui Zheng Ning Zhao Fang Cui Siting Wu Source Type: research
Tranexamic acid in a mouse model of cerebral amyloid angiopathy: setting the stage for a novel stroke treatment approach
CONCLUSION: Long-term TXA treatment does not alter brain Aβ levels or impact neurologic behavior in mice predisposed to amyloid deposition and had minor effects on the levels of inflammatory mediators. This finding supports the safety of TXA and lays the foundation for TXA as a novel treatment to reduce sICH in patients with CAA.PMID:37694270 | PMC:PMC10483050 | DOI:10.1016/j.rpth.2023.102166
Source: Thrombosis and Haemostasis - September 11, 2023 Category: Hematology Authors: Zikou Liu Fiona M McCutcheon Heidi Ho Joanne Chia Yunxin Xiao Isabel Tippett Charithani B Keragala Geoffrey C Cloud Robert L Medcalf Source Type: research
Lipoprotein(a) and risk of cognitive impairment in Black and White Americans: the Reasons for Geographic and Racial Differences in Stroke cohort
CONCLUSION: Higher Lp(a) was associated with increased risk of cognitive impairment in Black but not White individuals. Future studies should evaluate the biological and social mechanisms through which race and Lp(a) interact to increase risk of cognitive impairment.PMID:37694266 | PMC:PMC10491800 | DOI:10.1016/j.rpth.2023.102170
Source: Thrombosis and Haemostasis - September 11, 2023 Category: Hematology Authors: Miguel Arce Renter ía Leslie A McClure Peter W Callas Vanessa M LaBode-Richman Danielle S Kroll Jennifer J Manly Neil A Zakai Frederick Unverzagt Mary Cushman Source Type: research
Tranexamic acid in a mouse model of cerebral amyloid angiopathy: setting the stage for a novel stroke treatment approach
CONCLUSION: Long-term TXA treatment does not alter brain Aβ levels or impact neurologic behavior in mice predisposed to amyloid deposition and had minor effects on the levels of inflammatory mediators. This finding supports the safety of TXA and lays the foundation for TXA as a novel treatment to reduce sICH in patients with CAA.PMID:37694270 | PMC:PMC10483050 | DOI:10.1016/j.rpth.2023.102166
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Zikou Liu Fiona M McCutcheon Heidi Ho Joanne Chia Yunxin Xiao Isabel Tippett Charithani B Keragala Geoffrey C Cloud Robert L Medcalf Source Type: research
Dual Antiplatelet Therapy in Minor Stroke/Transient Ischemic Attack - An Updated Network Meta-Analysis
Can J Neurol Sci. 2023 Sep 11:1-12. doi: 10.1017/cjn.2023.287. Online ahead of print.NO ABSTRACTPMID:37694524 | DOI:10.1017/cjn.2023.287
Source: The Canadian Journal of Neurological Sciences - September 11, 2023 Category: Neurology Authors: Ronda Lun Gabriele Zitikyte Danielle Carole Roy Shan Dhaliwal Dar Dowlatshahi Source Type: research
