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Condition: Stroke
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Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone
Arch Pharm Res. 2023 Sep 20. doi: 10.1007/s12272-023-01462-1. Online ahead of print.ABSTRACTTolperisone, a muscle relaxant used for post-stroke spasticity, is metabolized to its main metabolite by CYP2D6 and to a lesser extent by CYP2C19 and CYP1A2. We investigated the effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on tolperisone pharmacokinetics. A 150 mg oral dose of tolperisone was given to 184 healthy Korean subjects and plasma concentrations of tolperisone were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). A 3.14-fold significant increase in AUC0-∞ was observed in ...
Source: Archives of Pharmacal Research - September 20, 2023 Category: Drugs & Pharmacology Authors: Ji-Young Byeon Chang-Keun Cho Pureum Kang Se-Hyung Kim Choon-Gon Jang Seok-Yong Lee Yun Jeong Lee Source Type: research
Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research
Neuroprotective effects of oxytocin against ischemic stroke in rats by blocking glutamate release and CREB-mediated DNA hypermethylation
Biomed Pharmacother. 2023 Sep 18;167:115520. doi: 10.1016/j.biopha.2023.115520. Online ahead of print.ABSTRACTGlutamate plays a crucial role in cognitive impairments after ischemic stroke. There is a scarcity of information about how glutamate-induced activation of cAMP-response element binding (CREB) signaling pathway regulates both the negative and positive regulators of synaptic plasticity. Recent studies have demonstrated the involvement of prominent epigenetic repressors, such as MeCP2 and DNMTs, in stroke. Neuroprotective effects of oxytocin against ischemia have been previously reported, while the underlying mechani...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xin-Yu Fan Guang Shi Yun-Peng Zhao Jing-Jing Yang Juan Feng Source Type: research
Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research
Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke
In this study, we found that PKD2 expression and activity were significantly upregulated in the ipsilateral side of the brain after transient focal cerebral ischemia, which coincides with the upregulation of PKD2 in primary neurons in response to in vitro ischemia, implying a potential role of PKD2 in neuronal survival in ischemic stroke. Using kinase-dead PKD2 knock-in (PKD2-KI) mice, we examined whether loss of PKD2 activity affected stroke outcomes in mice subjected to 1 h of transient middle cerebral artery occlusion (tMCAO) and 24 h of reperfusion. Our data demonstrated that PKD2-KI mice exhibited larger infarction vo...
Source: Neurobiology of Disease - September 20, 2023 Category: Neurology Authors: Jaclyn A Connelly Xuejing Zhang Yuzhou Chen Yapeng Chao Yejie Shi Tija C Jacob Q Jane Wang Source Type: research
Neuroprotective effects of oxytocin against ischemic stroke in rats by blocking glutamate release and CREB-mediated DNA hypermethylation
Biomed Pharmacother. 2023 Sep 18;167:115520. doi: 10.1016/j.biopha.2023.115520. Online ahead of print.ABSTRACTGlutamate plays a crucial role in cognitive impairments after ischemic stroke. There is a scarcity of information about how glutamate-induced activation of cAMP-response element binding (CREB) signaling pathway regulates both the negative and positive regulators of synaptic plasticity. Recent studies have demonstrated the involvement of prominent epigenetic repressors, such as MeCP2 and DNMTs, in stroke. Neuroprotective effects of oxytocin against ischemia have been previously reported, while the underlying mechani...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xin-Yu Fan Guang Shi Yun-Peng Zhao Jing-Jing Yang Juan Feng Source Type: research
Transport use limitations and its association with social participation among patients with stroke living in rural India
CONCLUSIONS: Independent use of different modes of transport, particularly public transportation, reduced among rural Indian stroke survivors. These transport limitations are significantly associated with reduced social participation, highlighting the need for interventions to improve accessibility and fostering greater community engagement for stroke survivors in this population.IMPLICATIONS FOR REHABILITATIONLimited transportation access limits social participation for stroke survivors in rural India.Study results show a significant decrease in independent transport use among stroke survivors, affecting their social part...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: Kajal Chavda V Prakash Source Type: research
Standardized circuit class group training versus individualized goal-directed group training to improve upper limb function in stroke survivors during in-patient rehabilitation: a pragmatic trial
CONCLUSIONS: A standardized training could reduce the mental workload for therapists, but patients seemed less engaged. A combination of both might be most beneficial.Trial registration: Dutch Trial Register: NL8844 and NL9471IMPLICATIONS FOR REHABILITATIONProviding a standardized training program after stroke reduces therapists' mental workload.Individualized goal-directed group training results in the best achievement of rehabilitation goals.A combination of standardized and individual training would use best of both intervention modalities.Patients should be involved in the co-creation developing process of training pro...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: S G Rozevink C M Beerepoot C K van der Sluis J M Hijmans Source Type: research
Geriatric patient with neurological symptoms and prolonged aPTT
Inn Med (Heidelb). 2023 Sep 20. doi: 10.1007/s00108-023-01581-3. Online ahead of print.ABSTRACTA 73-year-old man with dementia was referred to our clinic with hypernatremia and volume depletion. New-onset neurogenic dysphagia was likely the reason for both. The patient had chronic embolic strokes on the computed tomography (CT) images. Documentation from previous hospitalizations in different hospitals revealed a repeatedly prolonged activated partial thromboplastin time (aPTT); 5 years prior, antiphospholipid antibody syndrome had already been suspected, but the necessary workup was never completed. We diagnosed the patie...
Source: Hamostaseologie - September 20, 2023 Category: Hematology Authors: Aisuluu Atakanova Anne Heiligers Martin Kirschner Cornelius Bollheimer Susanne Fleig Source Type: research
The effects of low-intensity resistance training with blood flow restriction versus traditional resistance exercise on lower extremity muscle strength and motor functionin ischemic stroke survivors: a randomized controlled trial
CONCLUSION: LIRT-BFR produced a significant improvement in muscle strength, balance, walking capacity, and anxiety and depression in ischemic stroke patients, and the improvement are comparable to HIRT.CLINICAL TRIAL REGISTRATION: NCT05281679.PMID:37724785 | DOI:10.1080/10749357.2023.2259170
Source: Topics in Stroke Rehabilitation - September 19, 2023 Category: Neurology Authors: Ishtiaq Ahmed Rustem Mustafoglu Belgin Erhan Source Type: research
Readability of patient education material in stroke: a systematic literature review
CONCLUSION: Paper and online patient education materials exceed the reading level of stroke patients and the AMA recommended 6th grade level. Due to limitations in readability, stroke patients are not being adequately educated about their condition.PMID:37724783 | DOI:10.1080/10749357.2023.2259177
Source: Topics in Stroke Rehabilitation - September 19, 2023 Category: Neurology Authors: Aaron B Ahn Sajal Kulhari Amir Karimi Sophia Sundararajan Martha Sajatovic Source Type: research
A comparison of chronic conditions and health characteristics between cancer survivors and non-cancer survivors
DISCUSSION: These findings can be used by healthcare and public health practitioners to evaluate the programmatic efforts and resources, implement targeted interventions toward cancer survivors, and improve health and quality of life.PMID:37724026 | DOI:10.1177/17423953231180191
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Anjin Singh Michael Shayne Gallaway Addey Rascon Source Type: research
The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: A translational porcine model
In conclusion, we demonstrate a delicate balance between development of pulmonary ischemia-reperfusion injury and right ventricular function during lung transplantation. Furthermore, we provide a physiological basis for potential benefit of extracorporeal life support technology.PMID:37724349 | DOI:10.1152/ajplung.00281.2022
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 19, 2023 Category: Cytology Authors: Michaela Orlitov á Tom Verbelen Anna E Frick Arno Vanstapel Dieter Van Beersel Sofie Ordies Jan Van Slambrouck Janne Kaes Jin Xin Walter Coudyzer Stijn E Verleden Geert M Verleden Bart M Vanaudenaerde Dirk E Van Raemdonck Robin Vos Laurens J Ceulemans Pi Source Type: research
A comparison of chronic conditions and health characteristics between cancer survivors and non-cancer survivors
DISCUSSION: These findings can be used by healthcare and public health practitioners to evaluate the programmatic efforts and resources, implement targeted interventions toward cancer survivors, and improve health and quality of life.PMID:37724026 | DOI:10.1177/17423953231180191
Source: Chronic Illness - September 19, 2023 Category: General Medicine Authors: Anjin Singh Michael Shayne Gallaway Addey Rascon Source Type: research
Long-term outcomes after conservative and EDAS treatment for 111 elderly patients with moyamoya disease: longitudinal and cross-sectional study
CONCLUSIONS: The postoperative long-term stroke rate among elderly patients with MMD was lower in the EDAS group than in the conservative treatment group. Long-term stroke events were associated with advanced age, aneurysm, and initial ischemia after conservative treatment and only initial hemorrhage after EDAS.PMID:37724788 | DOI:10.3171/2023.7.JNS231060
Source: Journal of Neurosurgery - September 19, 2023 Category: Neurosurgery Authors: Jing-Jie Li Xiao-Peng Wang Qian-Nan Wang Xiang-Yang Bao Qing-Bao Guo Zi-Qing Kong Gan Gao Min-Jie Wang Si-Meng Liu He-Guan Fu Qian Zhang Lian Duan Source Type: research
