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Drug: Estradiol
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Total 6523 results found since Jan 2013.
The impact of non-caloric artificial sweetener aspartame on female reproductive system in mice model
CONCLUSION: Non-nutritive artificial sweeteners including aspartame negatively impact the function of ovaries and feedback mechanism of reproductive hormones by affecting the hypothalamic-pituitary-gonadal axis. In light of present findings the aspartame negatively impacted the reproductive system of female mice. More studies are required to identify the molecular mechanism and the pathways involved.PMID:37580716 | DOI:10.1186/s12958-023-01115-4
Source: Reproductive Biology - August 14, 2023 Category: Reproduction Medicine Authors: Ab Qayoom Naik Tabassum Zafar Vinoy K Shrivastava Source Type: research
ZnT 9 Involvement in Estradiol-Modulated Zinc Homeostasis of the Human Follicular Microenvironment
This study to provide tangible improvements to patient outcomes will make it a focus of both scientific and translational efforts in the future.PMID:37578601 | DOI:10.1007/s12011-023-03804-y
Source: Biological Trace Element Research - August 14, 2023 Category: Biology Authors: Hui Lu Xueying Wang Xiujia Zhang Wenbo Yu Xiaoli Guo Ruhua Wang Congcong Xie Jing Ma Shusong Wang Source Type: research
The impact of non-caloric artificial sweetener aspartame on female reproductive system in mice model
CONCLUSION: Non-nutritive artificial sweeteners including aspartame negatively impact the function of ovaries and feedback mechanism of reproductive hormones by affecting the hypothalamic-pituitary-gonadal axis. In light of present findings the aspartame negatively impacted the reproductive system of female mice. More studies are required to identify the molecular mechanism and the pathways involved.PMID:37580716 | PMC:PMC10424399 | DOI:10.1186/s12958-023-01115-4
Source: Reproductive Biology - August 14, 2023 Category: Reproduction Medicine Authors: Ab Qayoom Naik Tabassum Zafar Vinoy K Shrivastava Source Type: research
ZnT 9 Involvement in Estradiol-Modulated Zinc Homeostasis of the Human Follicular Microenvironment
This study to provide tangible improvements to patient outcomes will make it a focus of both scientific and translational efforts in the future.PMID:37578601 | DOI:10.1007/s12011-023-03804-y
Source: Biological Trace Element Research - August 14, 2023 Category: Biology Authors: Hui Lu Xueying Wang Xiujia Zhang Wenbo Yu Xiaoli Guo Ruhua Wang Congcong Xie Jing Ma Shusong Wang Source Type: research
Determination of lipemia acceptance thresholds for 31 immunoassay analytes
CONCLUSION: Most immunoassays evaluated in this study were found to be robust to lipemia interference. By using these thresholds, laboratories can report the immunoassay results from analyzing a lipemic patient sample in many cases.PMID:37572842 | DOI:10.1016/j.cca.2023.117508
Source: International Journal of Clinical Chemistry - August 12, 2023 Category: Chemistry Authors: Şerif Ercan Mustafa Tat Source Type: research
Estradiol mitigates stress-induced cardiac injury and inflammation by downregulating ADAM17 via the GPER-1/PI3K signaling pathway
Cell Mol Life Sci. 2023 Aug 12;80(9):246. doi: 10.1007/s00018-023-04886-6.ABSTRACTStress-induced cardiovascular diseases characterized by inflammation are among the leading causes of morbidity and mortality in postmenopausal women worldwide. Estradiol (E2) is known to be cardioprotective via the modulation of inflammatory mediators during stress. But the mechanism is unclear. TNFα, a key player in inflammation, is primarily converted to its active form by 'A Disintegrin and Metalloprotease 17' (ADAM17). We investigated if E2 can regulate ADAM17 during stress. Experiments were performed using female FVB wild-type (WT), C57...
Source: Cellular and Molecular Life Sciences : CMLS - August 12, 2023 Category: Cytology Authors: Joseph Adu-Amankwaah Aisha Bushi Rubin Tan Adebayo Oluwafemi Adekunle Gabriel Komla Adzika Marie Louise Ndzie Noah Iqra Nadeem Seyram Yao Adzraku Stephane Koda Richard Mprah Jie Cui Kexue Li Prosperl Ivette Wowui Hong Sun Source Type: research
Determination of lipemia acceptance thresholds for 31 immunoassay analytes
CONCLUSION: Most immunoassays evaluated in this study were found to be robust to lipemia interference. By using these thresholds, laboratories can report the immunoassay results from analyzing a lipemic patient sample in many cases.PMID:37572842 | DOI:10.1016/j.cca.2023.117508
Source: International Journal of Clinical Chemistry - August 12, 2023 Category: Chemistry Authors: Şerif Ercan Mustafa Tat Source Type: research
Estradiol mitigates stress-induced cardiac injury and inflammation by downregulating ADAM17 via the GPER-1/PI3K signaling pathway
Cell Mol Life Sci. 2023 Aug 12;80(9):246. doi: 10.1007/s00018-023-04886-6.ABSTRACTStress-induced cardiovascular diseases characterized by inflammation are among the leading causes of morbidity and mortality in postmenopausal women worldwide. Estradiol (E2) is known to be cardioprotective via the modulation of inflammatory mediators during stress. But the mechanism is unclear. TNFα, a key player in inflammation, is primarily converted to its active form by 'A Disintegrin and Metalloprotease 17' (ADAM17). We investigated if E2 can regulate ADAM17 during stress. Experiments were performed using female FVB wild-type (WT), C57...
Source: Cellular and Molecular Life Sciences : CMLS - August 12, 2023 Category: Cytology Authors: Joseph Adu-Amankwaah Aisha Bushi Rubin Tan Adebayo Oluwafemi Adekunle Gabriel Komla Adzika Marie Louise Ndzie Noah Iqra Nadeem Seyram Yao Adzraku Stephane Koda Richard Mprah Jie Cui Kexue Li Prosperl Ivette Wowui Hong Sun Source Type: research
Determination of lipemia acceptance thresholds for 31 immunoassay analytes
CONCLUSION: Most immunoassays evaluated in this study were found to be robust to lipemia interference. By using these thresholds, laboratories can report the immunoassay results from analyzing a lipemic patient sample in many cases.PMID:37572842 | DOI:10.1016/j.cca.2023.117508
Source: International Journal of Clinical Chemistry - August 12, 2023 Category: Chemistry Authors: Şerif Ercan Mustafa Tat Source Type: research
The effects of human amnion membrane-derived mesenchymal stem cells conditioned medium on ionizing radiation-induced premature ovarian failure and endoplasmic reticulum stress-related apoptosis mechanism
CONCLUSION: The application of hAMSCs-CM has been found to have a positive impact on follicles affected by radiation. After treatment, the number of primordial, primary, secondary, and graafian follicles, which had previously decreased due to radiation, showed an increase. Furthermore, the number of atretic follicles, which had been increasing due to radiation, showed a decrease. ER is one of the targets affected by ionizing radiation. After ionizing radiation, the expressions of ER stress-related markers and apoptosis markers increased in the ovary. After hAMSCs-CM administration, the expressions of these markers and numb...
Source: Reproductive Biology - August 11, 2023 Category: Reproduction Medicine Authors: Burak Un Busra Cetinkaya-Un Meryem Akpolat Fundagul Andic Yusufhan Yazir Source Type: research
Effects of exposure to the explosive and environmental pollutant 2,4,6-trinitrotoluene on ovarian follicle development in rats
Environ Sci Pollut Res Int. 2023 Aug 12. doi: 10.1007/s11356-023-29161-w. Online ahead of print.ABSTRACTAlthough 2,4,6-trinitrotoluene (TNT) is a dangerous carcinogen in environmental pollution, information on the reproductive effects of TNT explosive contamination is limited. To explore the possible ovarian effects, TNT explosive-exposed rat models were established, and Wistar female rats were exposed to low and high TNT (40 g and 80 g, air and internal) explosives. After a month of exposure, the estrous cycle, ovarian histopathology, and follicle counting were conducted. Serum hormones follicle-stimulating hormone (FSH),...
Source: Environmental Science and Pollution Research International - August 11, 2023 Category: Environmental Health Authors: Dai Lin Yiqin Chen Lisheng Liang Zuxiong Huang Yiwei Guo Ping Cai Wenxiang Wang Source Type: research
High estradiol reduces adult neurogenesis but strengthens functional connectivity within the hippocampus during spatial pattern separation in adult female rats
Horm Behav. 2023 Aug 9;155:105409. doi: 10.1016/j.yhbeh.2023.105409. Online ahead of print.ABSTRACTAdult neurogenesis in the dentate gyrus plays an important role for pattern separation, the process of separating similar inputs and forming distinct neural representations. Estradiol modulates neurogenesis and hippocampus function, but to date no examination of estradiol's effects on pattern separation have been conducted. Here, we examined estrogenic regulation of adult neurogenesis and functional connectivity in the hippocampus after the spatial pattern separation task in female rats. Ovariectomized Sprague-Dawley rats rec...
Source: Hormones and Behavior - August 11, 2023 Category: Endocrinology Authors: Shunya Yagi Stephanie E Lieblich Liisa A M Galea Source Type: research
