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Total 6523 results found since Jan 2013.
Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH)
CONCLUSION: Deterioration of glycemia (dysglycemia) occurred in 45.4% (5/11) of thalassemic females on long-term HRT. Additional studies are needed to elucidate the validity of our preliminary observations.PMID:37539597 | DOI:10.23750/abm.v94i4.14631
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Vincenzo De Sanctis Shahina Daar Ashraf Soliman Ploutarchos Tzoulis Salvatore Di Maio Christos Kattamis Source Type: research
CETP expression ameliorates endothelial function in female mice through estrogen receptor- α and endothelial nitric oxide synthase pathway
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00365.2023. Online ahead of print.ABSTRACTEndothelial dysfunction is an early manifestation of atherosclerosis. The cholesteryl ester transfer protein (CETP) has been considered pro-atherogenic by reducing plasma HDL levels. However, CETP may exhibit cell- or tissue-specific effects. We have previously reported that male mice expressing the human CETP gene show impaired endothelium-mediated vascular relaxation associated with oxidative stress. Although sexual dimorphisms on the metabolic role of CETP has been proposed, possible sex differences in the vascul...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Carolina M Lazaro Jamaira A Victorio Ana Paula Davel Helena C F Oliveira Source Type: research
Synergistic regulation of uterine radial artery adaptation to pregnancy by paracrine and haemodynamic factors
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00205.2023. Online ahead of print.ABSTRACTFetal growth throughout pregnancy relies on delivery of an increasing volume of maternal blood to the placenta. To facilitate this, the uterine vascular network adapts structurally and functionally, resulting in wider blood vessels with decreased flow-mediated reactivity. Impaired remodeling of the rate-limiting uterine radial arteries has been associated with fetal growth restriction. However, the mechanisms underlying normal or pathological radial artery remodeling are poorly understood. Here, we used pressure myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Hanna H Allerkamp Stephanie C Leighton Teagan Pole Alys R Clark Joanna L James Source Type: research
Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH)
CONCLUSION: Deterioration of glycemia (dysglycemia) occurred in 45.4% (5/11) of thalassemic females on long-term HRT. Additional studies are needed to elucidate the validity of our preliminary observations.PMID:37539597 | DOI:10.23750/abm.v94i4.14631
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Vincenzo De Sanctis Shahina Daar Ashraf Soliman Ploutarchos Tzoulis Salvatore Di Maio Christos Kattamis Source Type: research
CETP expression ameliorates endothelial function in female mice through estrogen receptor- α and endothelial nitric oxide synthase pathway
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00365.2023. Online ahead of print.ABSTRACTEndothelial dysfunction is an early manifestation of atherosclerosis. The cholesteryl ester transfer protein (CETP) has been considered pro-atherogenic by reducing plasma HDL levels. However, CETP may exhibit cell- or tissue-specific effects. We have previously reported that male mice expressing the human CETP gene show impaired endothelium-mediated vascular relaxation associated with oxidative stress. Although sexual dimorphisms on the metabolic role of CETP has been proposed, possible sex differences in the vascul...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Carolina M Lazaro Jamaira A Victorio Ana Paula Davel Helena C F Oliveira Source Type: research
Synergistic regulation of uterine radial artery adaptation to pregnancy by paracrine and haemodynamic factors
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00205.2023. Online ahead of print.ABSTRACTFetal growth throughout pregnancy relies on delivery of an increasing volume of maternal blood to the placenta. To facilitate this, the uterine vascular network adapts structurally and functionally, resulting in wider blood vessels with decreased flow-mediated reactivity. Impaired remodeling of the rate-limiting uterine radial arteries has been associated with fetal growth restriction. However, the mechanisms underlying normal or pathological radial artery remodeling are poorly understood. Here, we used pressure myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Hanna H Allerkamp Stephanie C Leighton Teagan Pole Alys R Clark Joanna L James Source Type: research
Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH)
CONCLUSION: Deterioration of glycemia (dysglycemia) occurred in 45.4% (5/11) of thalassemic females on long-term HRT. Additional studies are needed to elucidate the validity of our preliminary observations.PMID:37539597 | PMC:PMC10440782 | DOI:10.23750/abm.v94i4.14631
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Vincenzo De Sanctis Shahina Daar Ashraf Soliman Ploutarchos Tzoulis Salvatore Di Maio Christos Kattamis Source Type: research
Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
In this study, we report systemic changes in the molecular regulation of biological processes under multiple lifespan-extending interventions, by jointly leveraging systems-level analyses on two mouse liver proteomic datasets, which were generated in the NIA Longevity Consortium, and a previously published mouse liver transcriptomic dataset. Differential Rank Conservation (DIRAC) analyses of mouse liver proteomics and transcriptomics data show that mechanistically distinct lifespan-extending interventions (acarbose, 17α-estradiol, rapamycin, and calorie restriction) generally tighten the regulation of biological modules. ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Comparable bio-evaluation of curcumin and chitosan-encapsulated curcumin nanoparticles against the reprotoxic potential of fenpropathrin pyrethroid in rats: Genomic and morphometric prospectives
This study delves into the intricate exploration of potential toxic effects resulting from subchronic exposure to fenpropathrin (FNP) on the reproductive system of male SD rats. Adding to the novelty, our study undertakes a pioneering comparison of the effects of curcumin (CUR) and curcumin-encapsulated chitosan nanoparticles (CS.CUR.NPs) on these toxic effects. The study involved a cohort of sixty male SD rats (six groups): vehicle control, CUR, Cs.CUR.NPs, FNP, and two combination groups (FNP with CUR or Cs.CUR.NPs). The synthesized Cs.CUR.NPs nanoparticles underwent meticulous characterization using Fourier Infrared spe...
Source: Food and Chemical Toxicology - August 2, 2023 Category: Food Science Authors: Amany Abdel-Rahman Mohamed Amany Behairy Yasmina M Abd El-Hakim Mohamed M M Metwally Tarek Khamis Samah S Abuzahrah Ahmed E Abdelhamid Leena S Alqahtani Walaa M Essawi Badriyah S Alotaibi Manal Alosaimi Rehab Ahmed Ahmed El-Shaer Marwa Mahmoud Awad Eman S Source Type: research
