Filtered By:
Infectious Disease: Parasitic Diseases
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 28144 results found since Jan 2013.
Evaluation of recombinant Babesia gibsoni thrombospondin-related adhesive protein (BgTRAP) for the sero-diagnosis of canine babesiosis
Exp Parasitol. 2023 Sep 16:108621. doi: 10.1016/j.exppara.2023.108621. Online ahead of print.ABSTRACTCanine babesiosis, caused by Babesia gibsoni is one of the most significant tick-borne illnesses across the world. Light microscopy as well as polymerase chain reaction may fail in the diagnosis of disease when the level of parasitaemia is very low during subclinical and chronic cases. The serological techniques using a recombinant protein will be useful for the accurate and sensitive surveillance of the disease, especially in chronic cases. The present study describes the evaluation of recombinant N-terminal B. gibsoni Thr...
Source: Experimental Parasitology - September 18, 2023 Category: Parasitology Authors: Chundayil Kalarickal Deepa Anju Varghese Karapparambu Gopalan Ajith Kumar Ashwathappa Nandini Gatchanda Shravan Kumar Prabodh Kumar Hembram Chemmangattuvalappil Narendranath Dinesh Sanis Juliet Jess Vergis Ollukkara Krishnan Sindhu Reghu Ravindran Source Type: research
Seasonal and host-associated variation in bot fly (oestridae: cuterebrinae) parasitism of lagomorphs across an arid-land ecosystem in southern new mexico
J Parasitol. 2023 Oct 1;109(5):486-494. doi: 10.1645/22-106.ABSTRACTBot flies (Oestridae: Cuterebrinae) are obligate mammalian parasites that complete the larval stage of their life cycle under the skin of their host. Most detailed studies of bot fly larval disease ecology have been conducted in temperate deciduous zone rodent systems. To understand the relative importance of seasonal and spatial factors, as well as factors intrinsic to the host, in underpinning the likelihood and extent of parasitism by bot flies in non-rodent hosts as well as in arid-land ecosystems, we examined the dynamic for black-tailed jackrabbit (L...
Source: The Journal of Parasitology - September 18, 2023 Category: Parasitology Authors: Jessica T Martin Anna T Boyle Colton J Padilla Bethany E Bridges Charles R Britt Jaidyn Armijo-Sonnenberg Matthew E Gompper Source Type: research
Evaluation of recombinant Babesia gibsoni thrombospondin-related adhesive protein (BgTRAP) for the sero-diagnosis of canine babesiosis
Exp Parasitol. 2023 Sep 16:108621. doi: 10.1016/j.exppara.2023.108621. Online ahead of print.ABSTRACTCanine babesiosis, caused by Babesia gibsoni is one of the most significant tick-borne illnesses across the world. Light microscopy as well as polymerase chain reaction may fail in the diagnosis of disease when the level of parasitaemia is very low during subclinical and chronic cases. The serological techniques using a recombinant protein will be useful for the accurate and sensitive surveillance of the disease, especially in chronic cases. The present study describes the evaluation of recombinant N-terminal B. gibsoni Thr...
Source: Experimental Parasitology - September 18, 2023 Category: Parasitology Authors: Chundayil Kalarickal Deepa Anju Varghese Karapparambu Gopalan Ajith Kumar Ashwathappa Nandini Gatchanda Shravan Kumar Prabodh Kumar Hembram Chemmangattuvalappil Narendranath Dinesh Sanis Juliet Jess Vergis Ollukkara Krishnan Sindhu Reghu Ravindran Source Type: research
Chemoresistance Mechanisms in Non-Small Cell Lung Cancer-Opportunities for Drug Repurposing
Appl Biochem Biotechnol. 2023 Sep 18. doi: 10.1007/s12010-023-04595-7. Online ahead of print.ABSTRACTGlobally, lung cancer contributes significantly to the public health burden-associated mortality. As this form of cancer is insidious in nature, there is an inevitable diagnostic delay leading to chronic tumor development. Non-small cell lung cancer (NSCLC) constitutes 80-85% of all lung cancer cases, making this neoplasia form a prevalent subset of lung carcinoma. One of the most vital aspects for proper diagnosis, prognosis, and adequate therapy is the precise classification of non-small cell lung cancer based on biomarke...
Source: Applied Biochemistry and Biotechnology - September 18, 2023 Category: Biochemistry Authors: Rajdeep Kaur P K Suresh Source Type: research
Tubulin as a potential molecular target for resveratrol in Giardia lamblia trophozoites, in vitro and in silico approaches
Acta Trop. 2023 Sep 16:107026. doi: 10.1016/j.actatropica.2023.107026. Online ahead of print.ABSTRACTGiardia lamblia is a globally distributed protozoan parasite that causes intestinal disease. Recently, there is an increase in refractory cases of giardiasis to chemotherapeutic agents, and drugs available cause side effects that may limit its use or cause therapeutic non-compliance. Therefore, search for alternative and less harmful drugs to treat giardiasis is an important task. In this sense, resveratrol (RSV) is a polyphenol with a wide range of pharmacological effects such as antimicrobial, anticarcinogenic and antioxi...
Source: Acta Tropica - September 18, 2023 Category: Infectious Diseases Authors: Jos é Roberto Vargas-Villanueva Filiberto Guti érrez-Gutiérrez Mariana Garza-Ontiveros Sendar Daniel Nery-Flores Lizeth Guadalupe Campos-M úzquiz Dagoberto Vazquez-Obreg ón Raul Rodriguez-Herrera Lissethe Palomo-Ligas Source Type: research
Rottlerin impairs early and late steps of Toxoplasma gondii infection in human trophoblast cells and villous explants
Chem Biol Interact. 2023 Sep 16:110716. doi: 10.1016/j.cbi.2023.110716. Online ahead of print.ABSTRACTCongenital toxoplasmosis, caused by the opportunistic protozoan parasite T. gondii, can cause stillbirths, miscarriages and fetal abnormalities, as well as encephalitis and chorioretinitis in newborns. Available treatment options rely on antiparasitic drugs that have been linked to serious side effects, high toxicity and the development of drug-resistant parasites. The search for alternative therapeutics to treat this disease without acute toxicity for the mother and child is essential for the advancement of current therap...
Source: Chemico-Biological Interactions - September 18, 2023 Category: Molecular Biology Authors: Samuel Cota Teixeira Marina Paschoalino Guilherme de Souza Alessandra Monteiro Rosini Joed Pires de Lima Junior Luana Carvalho Luz Aryani Felixa Fajardo Mart ínez Rosiane Nascimento Alves Marcos Paulo Oliveira Almeida Jaqueline Lopes Damasceno Marcelo Jo Source Type: research
Light pollution may alter host-parasite interactions in aquatic ecosystems
Trends Parasitol. 2023 Sep 16:S1471-4922(23)00217-9. doi: 10.1016/j.pt.2023.08.013. Online ahead of print.ABSTRACTWith growing human populations living along freshwater shores and marine coastlines, aquatic ecosystems are experiencing rising levels of light pollution. Through its effects on hosts and parasites, anthropogenic light at night can disrupt host-parasite interactions evolved under a normal photoperiod. Yet its impact on aquatic parasites has been ignored to date. Here, I discuss the direct effects of light on the physiology and behaviour of parasite infective stages and their hosts. I argue that night-time light...
Source: Trends in Parasitology - September 18, 2023 Category: Parasitology Authors: Robert Poulin Source Type: research
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Comparative analysis of the severity and progression of cutaneous leishmaniasis caused by Leishmania tropica in untreated and glucantime-treated patients
In this study, we investigated immunological phenotypes for three groups: glucantime treated (n=30) and untreated (n=30) CL patients infected with Leishmania tropica (L. tropica), and healthy controls (n=20). T-lymphocytes (CD4+ and CD8+), and B lymphocytes (CD14+ and CD19+) were isolated using antibody-conjugated microbeads and magnetic field isolation to achieve high purity. A higher significant difference was observed between T-lymphocytes (CD4+ and CD8+), and B-lymphocytes (CD14+ and CD19+) cells in CL-infected groups before and after treatment (p<0.0001). When compared, there was also a significant difference among...
Source: Acta Tropica - September 17, 2023 Category: Infectious Diseases Authors: Shumaila Naz Aiman Aroosh Naeem Raza Arshad Islam Anam Fatima Yusuf Ozbel Seray Toz Obaid Hayat Shahid Waseem Source Type: research
Programming schistosomes - a crisper approach to transgenesis
This study outlines a promising strategy for functional genomics to study this parasite that causes a debilitating and neglected tropical disease.PMID:37718190 | DOI:10.1016/j.pt.2023.09.003
Source: Trends in Parasitology - September 17, 2023 Category: Parasitology Authors: Bernd H Kalinna Source Type: research
Comparative analysis of the severity and progression of cutaneous leishmaniasis caused by Leishmania tropica in untreated and glucantime-treated patients
In this study, we investigated immunological phenotypes for three groups: glucantime treated (n=30) and untreated (n=30) CL patients infected with Leishmania tropica (L. tropica), and healthy controls (n=20). T-lymphocytes (CD4+ and CD8+), and B lymphocytes (CD14+ and CD19+) were isolated using antibody-conjugated microbeads and magnetic field isolation to achieve high purity. A higher significant difference was observed between T-lymphocytes (CD4+ and CD8+), and B-lymphocytes (CD14+ and CD19+) cells in CL-infected groups before and after treatment (p<0.0001). When compared, there was also a significant difference among...
Source: Acta Tropica - September 17, 2023 Category: Infectious Diseases Authors: Shumaila Naz Aiman Aroosh Naeem Raza Arshad Islam Anam Fatima Yusuf Ozbel Seray Toz Obaid Hayat Shahid Waseem Source Type: research
Epidemiological, serological, and entomological aspects of visceral leishmaniasis (VL) in suspected new VL foci in Bangladesh
Acta Trop. 2023 Sep 14:107021. doi: 10.1016/j.actatropica.2023.107021. Online ahead of print.ABSTRACTThe study aimed to explore epidemiological, serological, and entomological aspects of visceral leishmaniasis (VL) in suspected new VL foci and assess the knowledge, attitude, and practices of the community living in the alleged new VL foci. The study investigated new visceral leishmaniasis (VL) cases reported between 2019 and 2020 in four sub-districts (Dharmapasha, Hakimpur, Islampur and Savar) where we tested 560 members using the rK39 rapid test and conducted vector collections in six neighbouring houses of the index cas...
Source: Acta Tropica - September 16, 2023 Category: Infectious Diseases Authors: Debashis Ghosh Md Utba Rashid Soumik Kha Sagar Md Rasel Uddin Shomik Maruf Prakash Ghosh Rajashree Chowdhury Md Abu Rahat Md Nazmul Islam M M Aktaruzzaman Abu Nayeem Mohammad Sohel Megha Raj Banjara Axel Kroeger Abraham Aseffa Dinesh Mondal Source Type: research
Both C57BL/KsJ (H2 < sup > d < /sup > Haplotype) and CB10-H2 (H2 < sup > b < /sup > Haplotype) Mice are Highly Susceptible to Congenital Toxoplasmosis
In conclusion, the high IFN-γ and TNF serum levels observed in C57BL/KsJ (H2d) and CB10-H2 (H2b) mice were involved in the poor pregnancy outcomes in congenital toxoplasmosis. In addition, the higher IFN-γ, IL-6 and TNF levels detected in C57BL/KsJ in relation to CB10-H2 mice on 8dP/8dI seem to be related to the genetic background of C57BL/6J mice that may have contributed to the worse pregnancy outcome in this mouse lineage.PMID:37716667 | DOI:10.1016/j.actatropica.2023.107022
Source: Acta Tropica - September 16, 2023 Category: Infectious Diseases Authors: Loyane Bertagnolli Coutinho M ário Cézar de Oliveira Ester Cristina Borges Araujo Fl ávia Batista Ferreira França Marcos Paulo Oliveira Almeida Yusmaris Cariaco Paulo Czarnewski Neide Maria Silva Source Type: research
Conditional expression of NanoLuc luciferase through a multimodular system offers rapid detection of antimalarial drug activity
Exp Parasitol. 2023 Sep 14:108620. doi: 10.1016/j.exppara.2023.108620. Online ahead of print.ABSTRACTConditional gene expression is a powerful tool to investigate putative vaccine and drug targets, especially in a haploid organism such as Plasmodium falciparum. Inducible systems based on regulation of either transcription, translation, protein or mRNA stability, among others, allow switching on an off the expression of any desired gene causing specific gain or loss of function phenotypes. However, those systems can be cumbersome involving the construction of large plasmids and generation of multiple transgenic parasite lin...
Source: Experimental Parasitology - September 16, 2023 Category: Parasitology Authors: Caroline Lima Ignasi B Verdaguer Gerhard Wunderlich Alejandro M Katzin Brendan S Crabb Paul R Gilson Mauro F Azevedo Source Type: research
