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Infectious Disease: Parasitic Diseases
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Biting rhythms and infection rates of anthropophilic sand fly species (Diptera: Phlebotominae) in sites with different land use in southern Mexico
Acta Trop. 2023 Sep 9:107014. doi: 10.1016/j.actatropica.2023.107014. Online ahead of print.ABSTRACTCould tropical forest conversion shape sand fly (Diptera: Phlebotominae) biting rhythms and Leishmania infection rates? Using a Shannon trap, we estimated the bite rate and infection prevalence among anthropophilic sand flies at sites with different land use in southern Mexico. We estimated the expected monthly infection rate of the Leishmania parasite along the gradient and generated information on the biting rhythm of sand flies in a poorly characterized cutaneous leishmaniasis endemic region. We used generalized mixed lin...
Source: Acta Tropica - September 11, 2023 Category: Infectious Diseases Authors: A C Montes de Oca-Aguilar M I Pav ón-Mendez K B L ópez-Ávila E I Sosa-Bibiano E A Rebollar-T éllez J A Palacio-Vargas E A Fern ández-Figueroa E N Lor ía-Cervera Source Type: research
Design, synthesis and antiplasmodial evaluation of new amide-, carbamate-, and ureido-type harmicines
Bioorg Med Chem. 2023 Sep 7;94:117468. doi: 10.1016/j.bmc.2023.117468. Online ahead of print.ABSTRACTMalaria, one of the oldest parasitic diseases, remains a global health threat, and the increasing resistance of the malaria parasite to current antimalarials is forcing the discovery of new, effective drugs. Harmicines, hybrid compounds in which harmine/β-carboline alkaloids and cinnamic acid derivatives are linked via an amide bond or a triazole ring, represent new antiplasmodial agents. In this work, we used a multiple linear regression technique to build a linear quantitative structure-activity relationship (QSAR) model...
Source: Bioorganic and Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Marina Marinovi ć Hrvoje Rimac Lais Pessanha de Carvalho C R ôla S Santana Kristina Pavi ć Jana Held Miguel Prud êncio Zrinka Raji ć Source Type: research
Biting rhythms and infection rates of anthropophilic sand fly species (Diptera: Phlebotominae) in sites with different land use in southern Mexico
Acta Trop. 2023 Sep 9:107014. doi: 10.1016/j.actatropica.2023.107014. Online ahead of print.ABSTRACTCould tropical forest conversion shape sand fly (Diptera: Phlebotominae) biting rhythms and Leishmania infection rates? Using a Shannon trap, we estimated the bite rate and infection prevalence among anthropophilic sand flies at sites with different land use in southern Mexico. We estimated the expected monthly infection rate of the Leishmania parasite along the gradient and generated information on the biting rhythm of sand flies in a poorly characterized cutaneous leishmaniasis endemic region. We used generalized mixed lin...
Source: Acta Tropica - September 11, 2023 Category: Infectious Diseases Authors: A C Montes de Oca-Aguilar M I Pav ón-Mendez K B L ópez-Ávila E I Sosa-Bibiano E A Rebollar-T éllez J A Palacio-Vargas E A Fern ández-Figueroa E N Lor ía-Cervera Source Type: research
Inhibition of carbonic anhydrase using aspirin is a novel method to block schistosomiasis infection of the parasitic trematode, Schistosoma mansoni, in the intermediate snail host, Biomphalaria glabrata
In this study, we investigated the role of CA inhibition in B. glabrata snails exposed to S. mansoni miracidia. We analyzed the expression of the B. glabrata CA encoding transcript in juvenile susceptible and resistant snails, with and without exposure to S. mansoni. Our results showed that the expression of the CA mRNA encoding transcript was upregulated during early and prolonged infection in susceptible snails (BBO2), but not in the resistant BS-90 stock. Notably, sodium salicylate, a form of aspirin, inhibited the expression of CA, post-exposure, to the parasite. Increasing research between parasites and cancer has sho...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Simone Parn Gabriela Lewis Matty Knight Source Type: research
Design, synthesis and antiplasmodial evaluation of new amide-, carbamate-, and ureido-type harmicines
Bioorg Med Chem. 2023 Sep 7;94:117468. doi: 10.1016/j.bmc.2023.117468. Online ahead of print.ABSTRACTMalaria, one of the oldest parasitic diseases, remains a global health threat, and the increasing resistance of the malaria parasite to current antimalarials is forcing the discovery of new, effective drugs. Harmicines, hybrid compounds in which harmine/β-carboline alkaloids and cinnamic acid derivatives are linked via an amide bond or a triazole ring, represent new antiplasmodial agents. In this work, we used a multiple linear regression technique to build a linear quantitative structure-activity relationship (QSAR) model...
Source: Bioorganic and Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Marina Marinovi ć Hrvoje Rimac Lais Pessanha de Carvalho C R ôla S Santana Kristina Pavi ć Jana Held Miguel Prud êncio Zrinka Raji ć Source Type: research
Inhibition of carbonic anhydrase using aspirin is a novel method to block schistosomiasis infection of the parasitic trematode, Schistosoma mansoni, in the intermediate snail host, Biomphalaria glabrata
In this study, we investigated the role of CA inhibition in B. glabrata snails exposed to S. mansoni miracidia. We analyzed the expression of the B. glabrata CA encoding transcript in juvenile susceptible and resistant snails, with and without exposure to S. mansoni. Our results showed that the expression of the CA mRNA encoding transcript was upregulated during early and prolonged infection in susceptible snails (BBO2), but not in the resistant BS-90 stock. Notably, sodium salicylate, a form of aspirin, inhibited the expression of CA, post-exposure, to the parasite. Increasing research between parasites and cancer has sho...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Simone Parn Gabriela Lewis Matty Knight Source Type: research
Schistosoma mansoni-induced oxidative stress triggers hepatocellular proliferation
CONCLUSIONS: Our data suggest that hepatocellular proliferation is triggered by S. mansoni egg-induced oxidative stress.PMID:37696392 | DOI:10.1016/j.jcmgh.2023.08.014
Source: Molecular Medicine - September 11, 2023 Category: Molecular Biology Authors: Verena von B ülow Maryam Schneider Dorothee Dreizler Lena Russ Anne Baier Nicola Buss Jakob Lichtenberger Lukas H ärle Heike M üller Annette Tschuschner Gabriele Schramm J örn Pons-Kühnemann Christoph G Grevelding Elke Roeb Martin Roderfeld Source Type: research
Multiple Hydatid Cysts in Rare Locations Treated with Albendazole: A Case Report
We report the case of a 33-year-old man admitted because of chest pain. Echocardiography had shown suspected round cyst in the myocardium. More diagnostic managements had demonstrated cystic lesion in the liver, spleen and lungs. There were also multiple cystic lesions in both lungs. He refused surgery and was taken to medical therapy. Myocardial involvement by hydatid cysts occurs very rarely. The main treatment approach for cardiac hydatid disease in patients should be surgery. The alternative treatment was done to those who refused surgical removal, adjuvant therapy such as albendazole for at least 1-6 months. Because m...
Source: Biomed Res - September 11, 2023 Category: Research Authors: Somayeh Sadeghi Farzin Ghiasi Amir Aria Mahnaz Momenzadeh Elahe Nasri Shadi Reisizadeh Mobarakeh Source Type: research
< em > Toxocara < /em > Infection in Dogs and Cats in Isfahan Province of Iran in 2021
CONCLUSION: Dogs and cats in Isfahan province of Iran were infected with Toxocara parasite. These infections can be potential risk for human toxocariasis.PMID:37694248 | PMC:PMC10492607 | DOI:10.4103/abr.abr_88_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Gholamreza Pourshahbazi Hossein Khanahmad Reza Khadivi Hossein A Yousefi Somayeh Mobarakeh Fatemeh Hossini Boldaji Hossein Yousefi Darani Source Type: research
A Novel Nested Multiplex Polymerase Chain Reaction Assay for Malaria Diagnosis Using the Hydroxymethyl Dihydropterin Pyrophosphokinase-Dihydropteroate Synthase (hppk-dhps) Gene
Am J Trop Med Hyg. 2023 Sep 11:tpmd230130. doi: 10.4269/ajtmh.23-0130. Online ahead of print.ABSTRACTThere are many techniques for malaria diagnosis. Currently, the nested polymerase chain reaction (PCR) method based on a small subunit ribosomal RNA gene (18S rRNA) has been used as a confirmatory method. However, this method is time-consuming, laborious, and costly. Therefore, the objective of this study was to develop nested multiplex PCR for Plasmodium species identification using the dihydropterin pyrophosphokinase-dihydropteroate synthase (hppk-dhps) gene. Genus- and species-specific primers for the hppk-dhps gene were...
Source: Am J Trop Med Hyg - September 11, 2023 Category: Infectious Diseases Authors: Natpasit Chaianantakul Tippawan Sungkapong Kanokwan Nikhomkham Kansuda Sanseewong Sawanya Kornsang Source Type: research
Design, synthesis and antiplasmodial evaluation of new amide-, carbamate-, and ureido-type harmicines
Bioorg Med Chem. 2023 Sep 7;94:117468. doi: 10.1016/j.bmc.2023.117468. Online ahead of print.ABSTRACTMalaria, one of the oldest parasitic diseases, remains a global health threat, and the increasing resistance of the malaria parasite to current antimalarials is forcing the discovery of new, effective drugs. Harmicines, hybrid compounds in which harmine/β-carboline alkaloids and cinnamic acid derivatives are linked via an amide bond or a triazole ring, represent new antiplasmodial agents. In this work, we used a multiple linear regression technique to build a linear quantitative structure-activity relationship (QSAR) model...
Source: Bioorganic and Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Marina Marinovi ć Hrvoje Rimac Lais Pessanha de Carvalho C R ôla S Santana Kristina Pavi ć Jana Held Miguel Prud êncio Zrinka Raji ć Source Type: research
