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Diverse pharmacological potential of pyridazine analogs against various diseases
Med Chem. 2023 Sep 13. doi: 10.2174/1573406419666230913102835. Online ahead of print.ABSTRACTPyridazinone analogs possess diverse types of pharmacological activities, such as anticancer, antimicrobial, anticonvulsant, analgesic, anti-inflammatory, antioxidant, antihypertensive, antisecretory, antiulcer, and other useful pharmacological activities. They also possess cyclooxygenase (COX) inhibitors, dipeptidyl peptidase inhibitors, phosphodiesterase inhibitors, glutamate transporter activators, adenosine receptor antagonists, serotonin receptors antagonists, lipooxygenase, cholinesterase, vasodilator, and anesthetics. Pyrida...
Source: Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Mohammad Asif Mazen M Almehmadi Ahad Amer Alsaiari Source Type: research

Low-Dose Remifentanil in Preterm Cesarean Section with General Anesthesia: A Randomized Controlled Trial
CONCLUSIONS: The use of a low dose of remifentanil before cord clamping for a Cesarean section appears to be safe both for the mother and the preterm newborn, but it does not improve maternal or neonatal outcomes.CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov: NCT02029898.PMID:37713021 | DOI:10.1007/s40272-023-00591-w
Source: Paediatric Drugs - September 15, 2023 Category: Pediatrics Authors: Cl ément Chollat Fabien Tourrel Estelle Houivet Romain Gillet Eric Verspyck Maryline Lecointre St éphane Marret Vincent Comp ère Source Type: research

Are we abandoning intubating supraglottic airway devices? We should not!
Can J Anaesth. 2023 Sep 15. doi: 10.1007/s12630-023-02576-2. Online ahead of print.NO ABSTRACTPMID:37715048 | DOI:10.1007/s12630-023-02576-2
Source: Canadian Journal of Anaesthesia - September 15, 2023 Category: Anesthesiology Authors: Fabricio B Zasso Kong Eric You-Ten Source Type: research

So, You Want Diversity, Equity, and Inclusion? Ten Practical Tips for Establishing Sustainable Change
Anesth Analg. 2023 Oct 1;137(4):772-776. doi: 10.1213/ANE.0000000000006489. Epub 2023 Sep 5.NO ABSTRACTPMID:37712468 | DOI:10.1213/ANE.0000000000006489
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Olubukola O Nafiu Source Type: research

The Women in Cardiothoracic Anesthesiology Special Interest Group: What Can the Lessons of One Anesthesiology Affinity Group Tell Us About How to Build Impactful Professional Communities?
This article discusses the recent history of affinity organizations in anesthesiology, the benefits they offer professional organizations, and the strategies that have been used to effectively motivate change in professional communities. These strategies include engaging a strong advisory board, identifying the need of constituents, creating additional opportunities for networking and membership, addressing gaps in professional development, and aligning goals with those of the larger national organization. WICTA is just one example of the potential opportunities that affinity groups offer to professional societies and orga...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Emily Methangkool Abimbola Faloye Lavinia Kolarczyk Seema Deshpande Kiran Belani Agnieszka Trzcinka Choy R Lewis Rebecca Mutesi Balimunkwe Daryl Oakes Source Type: research

Assuring the Groundwork for Success: Mentorship, Sponsorship, and Allyship for Practicing Anesthesiologists
Anesth Analg. 2023 Oct 1;137(4):754-762. doi: 10.1213/ANE.0000000000006646. Epub 2023 Sep 5.ABSTRACTThe challenges facing the health care industry in the post-coronavirus disease 2019 (COVID-19) pandemic world are numerous, jeopardizing wellness, and performance. Maintaining engagement and fulfillment of anesthesiologists in their work is now a critical issue in various practice settings: academic, private practice, and corporate medicine. In this article, we offer insights on how mentorship, sponsorship, and allyship are important in the advancement of the anesthesiology workforce including women and underrepresented mino...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Mofya S Diallo Crystal C Wright Alice A Tolbert Coombs Thomas R Vetter Source Type: research

Pro-Con Debate: Consideration of Race, Ethnicity, and Gender Is Detrimental to Successful Mentorship
Anesth Analg. 2023 Oct 1;137(4):747-753. doi: 10.1213/ANE.0000000000006502. Epub 2023 Sep 5.ABSTRACTAnesthesiology remains a specialty with low representation of women or members of racial and ethnic groups considered underrepresented in medicine (UiM). In the United States, women account for 33% of anesthesiology residents, while physicians identifying as Black, African American, Latinx, American Indian, or Alaska Native account for approximately 10%. Underrepresentation of these groups is even more pronounced in academic anesthesiology, especially at the senior ranks and roles, such as department chairs. Leaders in the f...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Alicia B Barclay Kenneth Moran Dmitry Tumin Kimberley R Nichols Source Type: research

Marching Toward Utopia: Mentor-Mentee Relationship Devoid of Race or Gender Considerations
Anesth Analg. 2023 Oct 1;137(4):744-746. doi: 10.1213/ANE.0000000000006621. Epub 2023 Sep 5.NO ABSTRACTPMID:37712464 | DOI:10.1213/ANE.0000000000006621
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Annery Garcia-Marcinkiewicz Travis Reece-Nguyen Olubukola O Nafiu Source Type: research

Mentorship and Concordance: A Pro Con Debate
Anesth Analg. 2023 Oct 1;137(4):743. doi: 10.1213/ANE.0000000000006681. Epub 2023 Sep 5.NO ABSTRACTPMID:37712463 | DOI:10.1213/ANE.0000000000006681
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Naveen Nathan Source Type: research

The Anesthesiology Physician-Scientist Pipeline: Current Status and Recommendations for Future Growth-An Initiative of the Anesthesia Research Council
Anesth Analg. 2023 Oct 1;137(4):728-742. doi: 10.1213/ANE.0000000000006520. Epub 2023 Sep 5.ABSTRACTThe limited number and diversity of resident physicians pursuing careers as physician-scientists in medicine has been a concern for many decades. The Anesthesia Research Council aimed to address the status of the anesthesiology physician-scientist pipeline, benchmarked against other medical specialties, and to develop strategic recommendations to sustain and expand the number and diversity of anesthesiology physician-scientists. The working group analyzed data from the Association of American Medical Colleges and the Nationa...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Charles W Emala Vivianne L Tawfik Meghan B Lane-Fall Paloma Toledo Cynthia A Wong Monica S Vavilala Lee A Fleisher Margaret Wood Source Type: research

Physician-Scientists in Anesthesiology: The All Too Empty Pipeline
Anesth Analg. 2023 Oct 1;137(4):725-727. doi: 10.1213/ANE.0000000000006648. Epub 2023 Sep 5.NO ABSTRACTPMID:37712461 | DOI:10.1213/ANE.0000000000006648
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Lawrence F Brass Nabil Thalji Dayle Q Hodge Myles H Akabas Source Type: research

A Call to Action: The Physician-Scientist Pipeline
Anesth Analg. 2023 Oct 1;137(4):724. doi: 10.1213/ANE.0000000000006680. Epub 2023 Sep 5.NO ABSTRACTPMID:37712460 | DOI:10.1213/ANE.0000000000006680
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Naveen Nathan Source Type: research

Asleep-awake-asleep versus hypnosis for low-grade glioma surgery: long term follow-up outcome
CONCLUSION: Hypnosis for awake craniotomy is rarely proposed although it is a suitable alternative to standard sedation in awake craniotomy for LGGs, with similar results in terms of extent of resection or survival.PMID:37714375 | DOI:10.1016/j.neuchi.2023.101494
Source: Neuro-Chirurgie - September 15, 2023 Category: Neurosurgery Authors: Nourou Dine Adeniran Bankole Ulrick Sidney Kanmounye Abdessamad El Ouahabi Ilyess Zemmoura Source Type: research

Diversity, Equity, and Inclusion: More Than Words
Anesth Analg. 2023 Oct 1;137(4):722-723. doi: 10.1213/ANE.0000000000006636. Epub 2023 Sep 5.NO ABSTRACTPMID:37712459 | DOI:10.1213/ANE.0000000000006636
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Paloma Toledo Crystal C Wright Thomas R Vetter Source Type: research

Adlocutio cohortium: Introduction of a New Editor-in-Chief
Anesth Analg. 2023 Oct 1;137(4):719-721. doi: 10.1213/ANE.0000000000006594. Epub 2023 Sep 5.NO ABSTRACTPMID:37712458 | DOI:10.1213/ANE.0000000000006594
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Jaideep J Pandit Source Type: research