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Procedure: Kidney Transplant
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Total 40417 results found since Jan 2013.
The mTOR Inhibitor Rapamycin Counteracts Follicle Activation Induced by Ovarian Cryopreservation in Murine Transplantation Models
Conclusions: By adding rapamycin during the OTCTP procedure, we were able to transiently maintain primordial follicles in a quiescent state. This is a promising method for improving the longevity of the ovarian graft. Furthermore, both the ear and kidney capsule transplantation models were suitable for investigating follicle activation and proliferation and pharmacological strategies.PMID:37629764 | PMC:PMC10456585 | DOI:10.3390/medicina59081474
Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Jules Bindels Marlyne Squatrito La ëtitia Bernet Michelle Nisolle Laurie Henry Carine Munaut Source Type: research
The CTNS-MTORC1 axis couples lysosomal cystine to epithelial cell fate decisions and is a targetable pathway in cystinosis
Autophagy. 2023 Aug 24:1-3. doi: 10.1080/15548627.2023.2250165. Online ahead of print.ABSTRACTDifferentiation and fate decisions are critical for the epithelial cells lining the proximal tubule (PT) of the kidney, but the signals involved remain unknown. Defective cystine mobilization from lysosomes through CTNS (cystinosin, lysosomal cystine transporter), which is mutated in cystinosis, triggers the dedifferentiation and dysfunction of the PT cells, causing kidney disease and severe metabolic complications. Using preclinical models and physiologically relevant cellular systems, along with functional assays and a generativ...
Source: Autophagy - August 25, 2023 Category: Cytology Authors: Alessandro Luciani Olivier Devuyst Source Type: research
In silico screening of nanoporous materials for urea removal in hemodialysis applications
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Thomas Fabiani, Eleonora Ricci, Cristiana Boi, Simone Dimartino, Maria Grazia De Angelis The design of miniaturized hemodialysis devices, such as wearable artificial kidneys, requires regeneration of the dialysate stream to remove uremic toxins from water. Adsorption has the potential to capture such... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - August 24, 2023 Category: Chemistry Authors: Thomas Fabiani Source Type: research
Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis
CONCLUSIONS: In our cohort, 17% of C3 glomerulopathy/Ig-MPGN cases were associated with rare variants in the CFH, CFI, or C3 genes. In the majority of cases, a quantitative deficiency in factor H or factor I is identified. The presence of a rare variant was associated with poor kidney survival.PMID:37615951 | DOI:10.2215/CJN.0000000000000252
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 24, 2023 Category: Urology & Nephrology Authors: Marie Sophie Meuleman Paula Vieira Martins Carine El Sissy Vincent Audard V éronique Baudouin Dominique Bertrand Frank Bridoux F érielle Louillet Claire Dossier Vincent Esnault No émie Jourde-Chiche Alexandre Karras Marie-Pascale Morin Fran çois Provo Source Type: research
Safety analysis of co-administering tacrolimus and omeprazole in renal transplant recipients - A review
Biomed Pharmacother. 2023 Aug 22;166:115149. doi: 10.1016/j.biopha.2023.115149. Online ahead of print.ABSTRACTTacrolimus is a calcineurin inhibitor used to prevent rejection in allogenic solid organ transplant recipients, which is metabolized in the liver with cytochrome P450 isoforms 3A4 and 3A5 (CYP3A4, CYP3A5). In turn, proton pump inhibitors (PPIs), such as Omeprazole - a substrate and inhibitor of CYP2C19 and CYP3A4 enzymes - are administered to kidney transplant patients in order to prevent duodenal and gastric ulcer disease, associated with the glucocorticoid treatment. Simultaneous administration of both drugs in r...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 24, 2023 Category: Drugs & Pharmacology Authors: Mi łosz Miedziaszczyk Ilona Idasiak-Piechocka Source Type: research
Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis
CONCLUSIONS: In our cohort, 17% of C3 glomerulopathy/Ig-MPGN cases were associated with rare variants in the CFH, CFI, or C3 genes. In the majority of cases, a quantitative deficiency in factor H or factor I is identified. The presence of a rare variant was associated with poor kidney survival.PMID:37615951 | DOI:10.2215/CJN.0000000000000252
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 24, 2023 Category: Urology & Nephrology Authors: Marie Sophie Meuleman Paula Vieira Martins Carine El Sissy Vincent Audard V éronique Baudouin Dominique Bertrand Frank Bridoux F érielle Louillet Claire Dossier Vincent Esnault No émie Jourde-Chiche Alexandre Karras Marie-Pascale Morin Fran çois Provo Source Type: research
Safety analysis of co-administering tacrolimus and omeprazole in renal transplant recipients - A review
Biomed Pharmacother. 2023 Aug 22;166:115149. doi: 10.1016/j.biopha.2023.115149. Online ahead of print.ABSTRACTTacrolimus is a calcineurin inhibitor used to prevent rejection in allogenic solid organ transplant recipients, which is metabolized in the liver with cytochrome P450 isoforms 3A4 and 3A5 (CYP3A4, CYP3A5). In turn, proton pump inhibitors (PPIs), such as Omeprazole - a substrate and inhibitor of CYP2C19 and CYP3A4 enzymes - are administered to kidney transplant patients in order to prevent duodenal and gastric ulcer disease, associated with the glucocorticoid treatment. Simultaneous administration of both drugs in r...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 24, 2023 Category: Drugs & Pharmacology Authors: Mi łosz Miedziaszczyk Ilona Idasiak-Piechocka Source Type: research
Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis
CONCLUSIONS: In our cohort, 17% of C3 glomerulopathy/Ig-MPGN cases were associated with rare variants in the CFH, CFI, or C3 genes. In the majority of cases, a quantitative deficiency in factor H or factor I is identified. The presence of a rare variant was associated with poor kidney survival.PMID:37615951 | DOI:10.2215/CJN.0000000000000252
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 24, 2023 Category: Urology & Nephrology Authors: Marie Sophie Meuleman Paula Vieira Martins Carine El Sissy Vincent Audard V éronique Baudouin Dominique Bertrand Frank Bridoux F érielle Louillet Claire Dossier Vincent Esnault No émie Jourde-Chiche Alexandre Karras Marie-Pascale Morin Fran çois Provo Source Type: research
hUC-MSC transplantation therapy effects on lupus-prone MRL/lpr mice at early disease stages
CONCLUSION: hUC-MSC transplantation could inhibit the proliferation and differentiation of peripheral blood B cells in the early-stage of MRL/lpr mice, thereby alleviating the plasma inflammatory environment in mice, leading to kidney injury remission. The study provides a new and feasible strategy for SLE treatment.PMID:37605271 | DOI:10.1186/s13287-023-03432-2
Source: Cell Research - August 22, 2023 Category: Cytology Authors: Fengbiao Guo Quanren Pan Ting Chen Shuzhen Liao Shangmei Li Aifen Li Shuxian Chen Jiaxuan Chen Zengzhi Xiao Hongyong Su Lawei Yang Chen Yang Hua-Feng Liu Qingjun Pan Source Type: research
Cardiorenal Biomarkers, Canagliflozin, and Outcomes in Diabetic Kidney Disease: The CREDENCE Trial
CONCLUSIONS: Multiple cardiorenal stress biomarkers are strongly prognostic in people with type 2 diabetes and albuminuria. Canagliflozin modestly reduced the longitudinal trajectory of rise in each biomarker. Change in the biomarker level in addition to the baseline level augments the primary outcome prediction.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT02065791.PMID:37603600 | DOI:10.1161/CIRCULATIONAHA.123.065251
Source: Circulation - August 21, 2023 Category: Cardiology Authors: James L Januzzi Reza Mohebi Yuxi Liu Naveed Sattar Hiddo J L Heerspink Eshetu Tefera Muthiah Vaduganathan Javed Butler Yshai Yavin Jingwei Li Carol A Pollock Vlado Perkovic Bruce Neal Michael K Hansen Source Type: research
