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Specialty: Urology & Nephrology
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Total 98151 results found since Jan 2013.
Renal-Tubular SGK1 is Required to Achieve Blood Pressure Surge and Circadian Rhythm
Am J Physiol Renal Physiol. 2023 Sep 7. doi: 10.1152/ajprenal.00211.2023. Online ahead of print.ABSTRACTBlood pressure (BP) follows a circadian pattern that rises during the active (morning surge) and decreases during the inactive (night dipping) phase of the day. Morning surge coincides with increased circulating Glucocorticoids and Aldosterone, ligands for GR and MR nuclear receptors respectively. Serum- and glucocorticoid-induced kinase (SGK1), a clock-controlled and GR- and MR-induced gene, plays a role in BP regulation in human and animal models. However, the role of SGK1 in BP circadian regulation has not yet been de...
Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Olivier Staub Anne Debonneville Matteo Stifanelli Alexandria Juffre Marc P Maillard Michelle L Gumz Lama Al-Qusairi Source Type: research
Elevated tacrolimus levels among COVID-19 kidney transplant recipients are associated with worse disease severity and clinical outcomes
CONCLUSION: Elevated tacrolimus levels occur in many renal transplant recipients with moderate to severe COVID-19 and are associated with worse clinical outcomes. Close drug monitoring is crucial to avoid toxicities and minimize over-immunosuppression complications.PMID:37675489 | DOI:10.5414/CN111137
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Angelito Yango Bipin Bista Bernard Fischbach Shana Machado Alexandra Clark Sanna Khoja Nicole Dion Giovana Saracino Jessica Taylor Hoylan Fernandez Sathishkumar Seeliyur Duraiswamy Giuliano Testa Source Type: research
Effect of canagliflozin in non-diabetic obese patients with albuminuria: A randomized, double-blind, placebo-controlled trial
CONCLUSION: Canagliflozin 100 mg daily was well tolerated but did not significantly reduce UACR in non-diabetic obese patients with microalbuminuria. However, a significant temporary decline in eGFR might reflect a subtle reduction in glomerular hyperfiltration.PMID:37675488 | DOI:10.5414/CN111143
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Primploy Greeviroj Pongpratch Puapatanakul Jeerath Phannajit Kullaya Takkavatakarn Wonngarm Kittanamongkolchai Patchaya Boonchaya-Anant Pisut Katavetin Kearkiat Praditpornsilpa Somchai Eiam-Ong Paweena Susantitaphong Source Type: research
Renal-Tubular SGK1 is Required to Achieve Blood Pressure Surge and Circadian Rhythm
Am J Physiol Renal Physiol. 2023 Sep 7. doi: 10.1152/ajprenal.00211.2023. Online ahead of print.ABSTRACTBlood pressure (BP) follows a circadian pattern that rises during the active (morning surge) and decreases during the inactive (night dipping) phase of the day. Morning surge coincides with increased circulating Glucocorticoids and Aldosterone, ligands for GR and MR nuclear receptors respectively. Serum- and glucocorticoid-induced kinase (SGK1), a clock-controlled and GR- and MR-induced gene, plays a role in BP regulation in human and animal models. However, the role of SGK1 in BP circadian regulation has not yet been de...
Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Olivier Staub Anne Debonneville Matteo Stifanelli Alexandria Juffre Marc P Maillard Michelle L Gumz Lama Al-Qusairi Source Type: research
Why is chronic kidney disease progressive? Evolutionary adaptations and maladaptations
Am J Physiol Renal Physiol. 2023 Sep 7. doi: 10.1152/ajprenal.00134.2023. Online ahead of print.ABSTRACTDespite significant advances in renal physiology, the global prevalence of chronic kidney disease (CKD) continues to increase. The emergence of multicellular organisms gave rise to increasing complexity of life resulting in tradeoffs reflecting ancestral adaptations to changing environments. Three evolutionary traits shape CKD over the lifespan: 1) variation in nephron number at birth, 2) progressive nephron loss with aging, and 3) adaptive kidney growth in response to decreased nephron number. Although providing plastic...
Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Robert L Chevalier Source Type: research
Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions
In conclusion, cholinergic detrusor contraction and RhoA activation are mediated by both M2 and M3 receptors. Furthermore, whereas both Gαi and Gαq/11 proteins mediate UBSM contraction, the activation at the RhoA-ROCK pathway appears to be linked specifically to Gαi. These findings may aid the identification of more specific therapeutic targets for bladder dysfunctions.PMID:37675459 | DOI:10.1152/ajprenal.00261.2022
Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Helga Balla Kinga Borsodi Petra Őrsy B éla Horváth P éter József Molnár Ádám Lénárt M ónika Kosztelnik Éva Ruisanchez J ürgen Wess Stefan Offermanns P éter Nyirády Zolt án Benyó Source Type: research
Renal-Tubular SGK1 is Required to Achieve Blood Pressure Surge and Circadian Rhythm
Am J Physiol Renal Physiol. 2023 Sep 7. doi: 10.1152/ajprenal.00211.2023. Online ahead of print.ABSTRACTBlood pressure (BP) follows a circadian pattern that rises during the active (morning surge) and decreases during the inactive (night dipping) phase of the day. Morning surge coincides with increased circulating Glucocorticoids and Aldosterone, ligands for GR and MR nuclear receptors respectively. Serum- and glucocorticoid-induced kinase (SGK1), a clock-controlled and GR- and MR-induced gene, plays a role in BP regulation in human and animal models. However, the role of SGK1 in BP circadian regulation has not yet been de...
Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Olivier Staub Anne Debonneville Matteo Stifanelli Alexandria Juffre Marc P Maillard Michelle L Gumz Lama Al-Qusairi Source Type: research
Why is chronic kidney disease progressive? Evolutionary adaptations and maladaptations
Am J Physiol Renal Physiol. 2023 Sep 7. doi: 10.1152/ajprenal.00134.2023. Online ahead of print.ABSTRACTDespite significant advances in renal physiology, the global prevalence of chronic kidney disease (CKD) continues to increase. The emergence of multicellular organisms gave rise to increasing complexity of life resulting in tradeoffs reflecting ancestral adaptations to changing environments. Three evolutionary traits shape CKD over the lifespan: 1) variation in nephron number at birth, 2) progressive nephron loss with aging, and 3) adaptive kidney growth in response to decreased nephron number. Although providing plastic...
Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Robert L Chevalier Source Type: research
Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions
In conclusion, cholinergic detrusor contraction and RhoA activation are mediated by both M2 and M3 receptors. Furthermore, whereas both Gαi and Gαq/11 proteins mediate UBSM contraction, the activation at the RhoA-ROCK pathway appears to be linked specifically to Gαi. These findings may aid the identification of more specific therapeutic targets for bladder dysfunctions.PMID:37675459 | DOI:10.1152/ajprenal.00261.2022
Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Helga Balla Kinga Borsodi Petra Őrsy B éla Horváth P éter József Molnár Ádám Lénárt M ónika Kosztelnik Éva Ruisanchez J ürgen Wess Stefan Offermanns P éter Nyirády Zolt án Benyó Source Type: research
Dialysis after kidney transplant failure: how to deal with this daunting task?
J Nephrol. 2023 Sep 7. doi: 10.1007/s40620-023-01758-x. Online ahead of print.ABSTRACTThe best treatment for patients with end-stage kidney disease is kidney transplantation, which, if successful provides both a reduction in mortality and a better quality of life compared to dialysis. Although there has been significant improvement in short-term outcomes after kidney transplantation, long-term graft survival still remains insufficient. As a result, there has been an increase in the number of individuals who need dialysis again after kidney transplant failure, and increasingly contribute to kidney transplant waiting lists. ...
Source: Journal of Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Cem Tanriover Sidar Copur Carlo Basile Duygu Ucku Mehmet Kanbay Source Type: research
Renal-Tubular SGK1 is Required to Achieve Blood Pressure Surge and Circadian Rhythm
Am J Physiol Renal Physiol. 2023 Sep 7. doi: 10.1152/ajprenal.00211.2023. Online ahead of print.ABSTRACTBlood pressure (BP) follows a circadian pattern that rises during the active (morning surge) and decreases during the inactive (night dipping) phase of the day. Morning surge coincides with increased circulating Glucocorticoids and Aldosterone, ligands for GR and MR nuclear receptors respectively. Serum- and glucocorticoid-induced kinase (SGK1), a clock-controlled and GR- and MR-induced gene, plays a role in BP regulation in human and animal models. However, the role of SGK1 in BP circadian regulation has not yet been de...
Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Olivier Staub Anne Debonneville Matteo Stifanelli Alexandria Juffre Marc P Maillard Michelle L Gumz Lama Al-Qusairi Source Type: research
Why is chronic kidney disease progressive? Evolutionary adaptations and maladaptations
Am J Physiol Renal Physiol. 2023 Sep 7. doi: 10.1152/ajprenal.00134.2023. Online ahead of print.ABSTRACTDespite significant advances in renal physiology, the global prevalence of chronic kidney disease (CKD) continues to increase. The emergence of multicellular organisms gave rise to increasing complexity of life resulting in tradeoffs reflecting ancestral adaptations to changing environments. Three evolutionary traits shape CKD over the lifespan: 1) variation in nephron number at birth, 2) progressive nephron loss with aging, and 3) adaptive kidney growth in response to decreased nephron number. Although providing plastic...
Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Robert L Chevalier Source Type: research
Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions
In conclusion, cholinergic detrusor contraction and RhoA activation are mediated by both M2 and M3 receptors. Furthermore, whereas both Gαi and Gαq/11 proteins mediate UBSM contraction, the activation at the RhoA-ROCK pathway appears to be linked specifically to Gαi. These findings may aid the identification of more specific therapeutic targets for bladder dysfunctions.PMID:37675459 | DOI:10.1152/ajprenal.00261.2022
Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Helga Balla Kinga Borsodi Petra Őrsy B éla Horváth P éter József Molnár Ádám Lénárt M ónika Kosztelnik Éva Ruisanchez J ürgen Wess Stefan Offermanns P éter Nyirády Zolt án Benyó Source Type: research
Elevated tacrolimus levels among COVID-19 kidney transplant recipients are associated with worse disease severity and clinical outcomes
CONCLUSION: Elevated tacrolimus levels occur in many renal transplant recipients with moderate to severe COVID-19 and are associated with worse clinical outcomes. Close drug monitoring is crucial to avoid toxicities and minimize over-immunosuppression complications.PMID:37675489 | DOI:10.5414/CN111137
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Angelito Yango Bipin Bista Bernard Fischbach Shana Machado Alexandra Clark Sanna Khoja Nicole Dion Giovana Saracino Jessica Taylor Hoylan Fernandez Sathishkumar Seeliyur Duraiswamy Giuliano Testa Source Type: research
Effect of canagliflozin in non-diabetic obese patients with albuminuria: A randomized, double-blind, placebo-controlled trial
CONCLUSION: Canagliflozin 100 mg daily was well tolerated but did not significantly reduce UACR in non-diabetic obese patients with microalbuminuria. However, a significant temporary decline in eGFR might reflect a subtle reduction in glomerular hyperfiltration.PMID:37675488 | DOI:10.5414/CN111143
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Primploy Greeviroj Pongpratch Puapatanakul Jeerath Phannajit Kullaya Takkavatakarn Wonngarm Kittanamongkolchai Patchaya Boonchaya-Anant Pisut Katavetin Kearkiat Praditpornsilpa Somchai Eiam-Ong Paweena Susantitaphong Source Type: research
