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Specialty: Cardiology
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Total 109230 results found since Jan 2013.
Single-Cell RNA Sequencing Reveals Cellular Adaptation of Human Aortic Endothelial Cells to Antiproliferative Therapies Is Modulated by Flow-Induced Shear Stress
CONCLUSIONS: We showed that flow shear stress modulates the cellular capacity of ECs to respond to paclitaxel and rapamycin administration, suggesting that while responding to different flow patterns, ECs experience an impairment in their transcriptional adaptation to other stimuli.PMID:37732484 | DOI:10.1161/ATVBAHA.123.319283
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Antonio G Salazar-Mart ín Aditya S Kalluri Martin A Villanueva Travis K Hughes Marc H Wadsworth Ii Tyler T Dao Mercedes Balcells Farhad R Nezami Alex K Shalek Elazer R Edelman Source Type: research
Aging Is Associated With Organ-Specific Alterations in the Level and Expression Pattern of von Willebrand Factor
CONCLUSIONS: Aging elicits a heterogenic response in endothelial cells with regard to VWF expression, leading to organ-specific increase in VWF levels and alterations in vascular tree pattern of expression. This is concomitant with increased platelet aggregate formation. The age-associated increase in VWF expression may be modulated through the process of cell senescence, and p53 transcription factor contributes to its regulation.PMID:37732483 | DOI:10.1161/ATVBAHA.123.319255
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Parnian Alavi Radya Yousef Abdualla Douglas Brown Anahita Mojiri Jayan Nagendran John Lewis Stephane L Bourque Nadia Jahroudi Source Type: research
Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm
CONCLUSIONS: These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.PMID:37732482 | DOI:10.1161/ATVBAHA.123.319695
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Natalia Col ás-Algora Pablo Mu ñoz-Pinillos Cristina Cacho-Navas Jos é Avendaño-Ortiz Gema de Rivas Susana Barroso Eduardo L ópez-Collazo Jaime Mill án Source Type: research
Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research
Oral Anticoagulation Use and Left Atrial Appendage Occlusion in LAAOS III
CONCLUSIONS: The benefit of LAA occlusion was consistent whether patients were receiving OACs or not. LAA occlusion provides thromboembolism reduction in patients independent of OAC use.PMID:37732457 | DOI:10.1161/CIRCULATIONAHA.122.060315
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Stuart J Connolly Jeff S Healey Emilie P Belley-Cote Kumar Balasubramanian Domenico Paparella Katheryn Brady Wilko Reents Bernhard C Danner P J Devereaux Mukul Sharma Chinthanie Ramasundarahettige Salim Yusuf Richard P Whitlock Source Type: research
Existing Nongated CT Coronary Calcium Predicts Operative Risk in Patients Undergoing Noncardiac Surgeries (ENCORES)
CONCLUSIONS: Prevalence and severity of coronary calcium obtained from existing nongated chest CT imaging improve preoperative clinical risk stratification before nongated surgery.PMID:37732454 | DOI:10.1161/CIRCULATIONAHA.123.064398
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Daniel Y Choi Dena Hayes Samuel D Maidman Nehal Dhaduk Jill E Jacobs Anna Shmukler Jeffrey S Berger Germaine Cuff David Rehe Mitchell Lee Robert Donnino Nathaniel R Smilowitz Source Type: research
Cardiovascular Imaging in Contemporary Cardio-Oncology: A Scientific Statement From the American Heart Association
Circulation. 2023 Sep 21. doi: 10.1161/CIR.0000000000001174. Online ahead of print.ABSTRACTAdvances in cancer therapeutics have led to dramatic improvements in survival, now inclusive of nearly 20 million patients and rising. However, cardiovascular toxicities associated with specific cancer therapeutics adversely affect the outcomes of patients with cancer. Advances in cardiovascular imaging have solidified the critical role for robust methods for detecting, monitoring, and prognosticating cardiac risk among patients with cancer. However, decentralized evaluations have led to a lack of consensus on the optimal uses of ima...
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Daniel Addison Tomas G Neilan Ana Barac Marielle Scherrer-Crosbie Tochi M Okwuosa Juan C Plana Kerryn W Reding Viviany R Taqueti Eric H Yang Vlad G Zaha American Heart Association Council on Cardiovascular Radiology and Intervention; Cardio-Oncology Commi Source Type: research
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Takotsubo syndrome: From a reversible to a chronic condition in search for the Ariadne's ball of string
Takotsubo syndrome (TTS), originally named because of the shape that the left ventricle takes during the acute phase resembling a Japanese octopus trap, has undergone during the last 20 years a significant revaluation from being considered a form of cardiomyopathy to reversable acute heart failure syndrome [1,2].
Source: International Journal of Cardiology - September 21, 2023 Category: Cardiology Authors: Maria-Angela Losi, Felice Borrelli, Eduardo Bossone, Giovanni Esposito Tags: Editorial Source Type: research
In Search of the “True” Left Bundle Branch Block: The art of asking research questions.
Conduction system pacing (CSP) is a promising new approach for delivering pacing therapy.1 The CSP offers an elegant treatment solution to the challenging problem of heart failure (HF) caused by electrical dyssynchrony due to the left bundle branch block (LBBB). Pacing therapy of LBBB-caused electrical dyssynchrony has a long and successful history. Cardiac resynchronization therapy (CRT) improves survival and quality of life and reduces HF hospitalizations in HF patients with LBBB.1 Striving to improve patient outcomes, the field opened the quest for the “true” LBBB.
Source: Heart Rhythm - September 21, 2023 Category: Cardiology Authors: Larisa G. Tereshchenko Source Type: research
Δ < sup > 9 < /sup > -Tetrahydrocannabinol Effects on Respiration and Heart Rate Across Route of Administration in Female and Male Mice
This study highlights important differences in the timeline of cardiopulmonary response to THC following the most common preclinical routes of administration.PMID:37728714 | DOI:10.1007/s12012-023-09810-9
Source: Cardiovascular Toxicology - September 20, 2023 Category: Cardiology Authors: Lucas T Laudermilk Julie A Marusich Jenny L Wiley Source Type: research
The assessment of thoracal approaches in the treatment of aortic coarctation
CONCLUSION: Thoracotomy provided feasible surgical access that led to satisfactory results with a low complication rate, negligible residual gradient, low incidence of hypertension and excellent rate for freedom from re-intervention in the treatment of CoA.PMID:37728294 | DOI:10.5830/CVJA-2023-039
Source: Cardiovascular Journal of Africa - September 20, 2023 Category: Cardiology Authors: Onur I şık G ökmen Akkaya Fatih Durak Defne Eng ür Meltem Çakmak Ali Rahmi Bakiler Muhammet Aky üz Source Type: research
Sirtuin1, not NAMPT, possesses anti-inflammatory effects in epicardial, pericardial and subcutaneous adipose tissue in patients with CHD
CONCLUSION: The study indicates that targeting SIRT1, with its anti-inflammatory properties, may be a novel anti-inflammatory strategy in preventing atherosclerosis and CHD progression. NAMPT may be an early player in AT inflammation, mediating/reflecting a pro-inflammatory state.TRIAL REGISTRATION: Registration: Clinicaltrials.gov ID: NCT02760914, registered the 5th of February 2016, http://clinicaltrials.gov/NCT02760914.PMID:37730614 | DOI:10.1186/s12967-023-04518-4
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Trine Baur Opstad Bianca Papotti Sissel Åkra Charlotte Holst Hansen Bj ørn Braathen Theis T ønnessen Svein Solheim Ingebj ørg Seljeflot Source Type: research
Sex differences in lipids: A life course approach
Atherosclerosis. 2023 Sep 1:117270. doi: 10.1016/j.atherosclerosis.2023.117270. Online ahead of print.ABSTRACTDifferences between men and women in lipids and lipoproteins are observed in distribution and trajectory from infancy to adulthood in the general population. However, these differences are more pronounced in hereditary lipid disorders such as familial hypercholesterolemia (FH) when absolute cholesterol levels are higher from birth onwards. In the early life course, girls compared to boys have higher low-density lipoprotein cholesterol (LDL-C) levels and total cholesterol, while high-density lipoprotein cholesterol ...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Kirsten B Holven Jeanine Roeters van Lennep Source Type: research
Pulsed-Field Ablation for Atrial Fibrillation - Achieving Excellence With a Simplified Technique
Circ J. 2023 Sep 21. doi: 10.1253/circj.CJ-23-0596. Online ahead of print.NO ABSTRACTPMID:37730372 | DOI:10.1253/circj.CJ-23-0596
Source: Circulation Journal - September 20, 2023 Category: Cardiology Authors: Koichi Inoue Source Type: research
