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Specialty: Cardiology
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Δ < sup > 9 < /sup > -Tetrahydrocannabinol Effects on Respiration and Heart Rate Across Route of Administration in Female and Male Mice
This study highlights important differences in the timeline of cardiopulmonary response to THC following the most common preclinical routes of administration.PMID:37728714 | DOI:10.1007/s12012-023-09810-9
Source: Cardiovascular Toxicology - September 20, 2023 Category: Cardiology Authors: Lucas T Laudermilk Julie A Marusich Jenny L Wiley Source Type: research
Coronary atherosclerotic plaque phenotype and physiopathologic mechanisms: Is there an influence of sex? Insights from intracoronary imaging
Atherosclerosis. 2023 Sep 18:117273. doi: 10.1016/j.atherosclerosis.2023.117273. Online ahead of print.ABSTRACTCoronary artery disease (CAD) is the leading cause of disability and death in both women and men; considerable differences in clinical presentation, natural history and prognosis are reported between sexes. Different pathophysiological mechanisms play a major role, including sex-related and gender-related features or a combination of both. Reports from intracoronary imaging studies pointed towards morphological plaque features, which seemed to differ between men and women, albeit results reported so far were not c...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Filippo Luca Gurgoglione Emilia Solinas Bettina Pfleiderer Antonella Vezzani Giampaolo Niccoli Source Type: research
Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review
J Am Coll Cardiol. 2023 Sep 26;82(13):1343-1359. doi: 10.1016/j.jacc.2023.06.045.ABSTRACTReducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD). However, a substantial number of individuals develop coronary atherosclerosis despite no SMuRFs. SMuRFless patients presenting with myocardial infarction have been observed to have an unexpected higher early mortality compared to their counterparts with at least 1 SMuRF. Evidence for optimal management of these patients is lacking. We assembled an international, mu...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Gemma A Figtree Stephen T Vernon Jason A Harmer Michael P Gray Clare Arnott Eric Bachour Giannie Barsha David Brieger Alex Brown David S Celermajer Keith M Channon Nicholas W S Chew James J H Chong Clara K Chow Peter A Cistulli Patrick T Ellinor Stuart M Source Type: research
AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway
In this study, we found that activation of AMPK by AICAR and metformin inhibits foam cell formation via suppression of mTOR in macrophages. Specifically, activation of AMPK indirectly reduced the phosphorylation level of mTOR at Ser2448 and promoted the expression of cholesterol efflux transporters and cholesterol efflux. These inhibitory effects on foam cell formation were counteracted by mTOR activators. Metformin, a more nonspecific AMPK activator than AICAR, appears to inhibit foam cell formation via anti-inflammatory effects in addition to suppression of the mTOR pathway. The results of this study suggest that the dev...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Reina Owaki Hiromasa Aoki Kohki Toriuchi Yasumichi Inoue Hidetoshi Hayashi Satoru Takeshita Hiroki Kakita Yasumasa Yamada Mineyoshi Aoyama Source Type: research
Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice
Cell Rep Med. 2023 Sep 19;4(9):101193. doi: 10.1016/j.xcrm.2023.101193.ABSTRACTIncreased liver de novo lipogenesis (DNL) is a hallmark of nonalcoholic steatohepatitis (NASH). A key enzyme controlling DNL upregulated in NASH is ATP citrate lyase (ACLY). In mice, inhibition of ACLY reduces liver steatosis, ballooning, and fibrosis and inhibits activation of hepatic stellate cells. Glucagon-like peptide-1 receptor (GLP-1R) agonists lower body mass, insulin resistance, and steatosis without improving fibrosis. Here, we find that combining an inhibitor of liver ACLY, bempedoic acid, and the GLP-1R agonist liraglutide reduces li...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Eric M Desjardins Jianhan Wu Declan C T Lavoie Elham Ahmadi Logan K Townsend Marisa R Morrow Dongdong Wang Evangelia E Tsakiridis Battsetseg Batchuluun Russta Fayyazi Jacek M Kwiecien Theodoros Tsakiridis James S V Lally Guillaume Par é Stephen L Pinkosk Source Type: research
Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease
Biomed Pharmacother. 2023 Sep 18;167:115469. doi: 10.1016/j.biopha.2023.115469. Online ahead of print.ABSTRACTExtracellular matrix (ECM) is an active player in cardiovascular calcification (CVC), a major public health issue with an unmet need for effective therapies. Lysyl oxidase (LOX) conditions ECM biomechanical properties; thus, we hypothesized that LOX might impact on mineral deposition in calcific aortic valve disease (CAVD) and atherosclerosis. LOX was upregulated in calcified valves from two cohorts of CAVD patients. Strong LOX immunostaining was detected surrounding calcified foci in calcified human valves and ath...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Carme Ballester-Servera Judith Alonso Laia Ca ñes Paula V ázquez-Sufuentes L ídia Puertas-Umbert Amaya Fern ández-Celis Manel Taur ón Antonio Rodr íguez-Sinovas Natalia L ópez-Andrés Cristina Rodr íguez Jos é Martínez-González Source Type: research
Surrogate Adiposity Markers and Mortality
CONCLUSIONS AND RELEVANCE: In this cohort study, WHR had the strongest and most consistent association with mortality irrespective of BMI. Clinical recommendations should consider focusing on adiposity distribution compared with mass.PMID:37728925 | DOI:10.1001/jamanetworkopen.2023.34836
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Irfan Khan Michael Chong Ann Le Pedrum Mohammadi-Shemirani Robert Morton Christina Brinza Michel Kiflen Sukrit Narula Loubna Akhabir Shihong Mao Katherine Morrison Marie Pigeyre Guillaume Par é Source Type: research
Platelet factor 4 (PF4) induces cluster of differentiation 40 (CD40) expression in human aortic endothelial cells (HAECs) through the SIRT1/NF- κB/p65 signaling pathway
In conclusion, our findings suggest that PF4 treatment facilitates CD40 expression in HAECs through the SIRT1/NF-κB/p65 pathway.PMID:37728854 | DOI:10.1007/s11626-023-00808-9
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Ming Zhong Xue-Hu Wang Yu Zhao Source Type: research
Ox-LDL promotes M1-like polarization of macrophages through the miR-21-5p/SKP2/EP300 pathway
This study shows that ox-LDL activates the SKP2/EP300 pathway through promoting upregulation of miR-21-5p, thereby acetylating and secreting HMGB1 outside the endothelium, subsequently enhancing macrophage polarization to further stabilize the inflammation situation.PMID:37728154 | DOI:10.1002/jbt.23516
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Jinlei Wu Tingting Liu Wenjie Xie Yufeng Zhuo Yanling Feng Source Type: research
Identification of the shared mechanisms and common biomarkers between Sj ögren's syndrome and atherosclerosis using integrated bioinformatics analysis
CONCLUSION: This is the first study to explore the common mechanism between SS and AS. Four key genes, including CTSS, CYBB, IRF8, and PTPRC, were associated with the pathogenesis of SS and AS. These hub genes and their correlation with immune cells could be a potential diagnostic and therapeutic target.PMID:37727764 | PMC:PMC10506082 | DOI:10.3389/fmed.2023.1185303
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Xiaoyi Qi Qianwen Huang Shijia Wang Liangxian Qiu Xiongbiao Chen Kunfu Ouyang Yanjun Chen Source Type: research
Assessing the Association between Psoriasis and Cardiovascular Ischemia: An Investigation of Vascular Endothelial Growth Factor, Cutaneous Angiogenesis, and Arterial Stiffness
CONCLUSION: According to this study, patients with psoriasis are at a higher risk of developing cardiovascular ischemia due to excessive angiogenesis associated with the condition. VEGF plays a key role in atheroma formation in psoriasis patients.PMID:37727549 | PMC:PMC10506815 | DOI:10.4103/idoj.idoj_246_23
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Alpana Mohta Achala Mohta Bhikam C Ghiya Source Type: research
AnnexinA6: a potential therapeutic target gene for extracellular matrix mineralization
Front Cell Dev Biol. 2023 Sep 4;11:1201200. doi: 10.3389/fcell.2023.1201200. eCollection 2023.ABSTRACTThe mineralization of the extracellular matrix (ECM) is an essential and crucial process for physiological bone formation and pathological calcification. The abnormal function of ECM mineralization contributes to the worldwide risk of developing mineralization-related diseases; for instance, vascular calcification is attributed to the hyperfunction of ECM mineralization, while osteoporosis is due to hypofunction. AnnexinA6 (AnxA6), a Ca2+-dependent phospholipid-binding protein, has been extensively reported as an essential...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Jie Yang Tong Pei Guanyue Su Peiyan Duan Xiaoheng Liu Source Type: research
Plasma Levels of Interleukin-6 and -18 Significantly Increase in Patients with Acute Coronary Syndrome
CONCLUSIONS: Both IL-6 and IL-18 are associated with ACS.PMID:37727149 | PMC:PMC10505690 | DOI:10.5001/omj.2023.94
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Qurrat Ul Ain Triwedya Indra Dewi Neng Fisheri Kurniati Source Type: research
Role of the tripartite motif-containing (TRIM) family of proteins in insulin resistance and related disorders
Diabetes Obes Metab. 2023 Sep 19. doi: 10.1111/dom.15294. Online ahead of print.ABSTRACTEmerging evidence suggests that the ubiquitin-mediated degradation of insulin-signalling-related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif-containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein levels and function by ubiquitination, which is essential for the modulation of insulin sensitivity. Recent research has indicated that some of these TRIMs act as key regulatory factors of metabolic disorders such as ty...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Jianrong Chen Xianjie Feng Xu Zhou Yong Li Source Type: research
EXPRESS: Association between monocyte to high-density lipoprotein-cholesterol (HDL-C) ratio and osteoporosis: an analysis of the National Health and Nutrition Examination Survey (NHANES) 2013-2014
This study aimed to assess the relationship between monocyte-to-HDL-C ratio and osteoporosis. Participants aged ≥50 years with complete bone mineral density (BMD), monocyte, and HDL-C examination data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 were included. Descriptive analysis was performed separately according to males and females. Weight linear regression and weight logistic regression analyses were used to analyze the association between monocyte-to-HDL-C ratio and BMD and osteopenia and osteoporosis and vertebral fracture. A total of 1,804 participants were included. Among the part...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Fushan Zhou Liyong Wu Guizhou Shen Xintan Chen Chaoyang Liu Dongqin Huang Mingmei Li Chengwei Xie Ruyu Zhan Source Type: research
