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Nimg-64. novel methods for genotype-phenotype correlation in schwannomatosis
In conclusion, we used a highly efficient method for deep, targeted germline sequencing in patients with schwannomatosis. While numbers were small, pain was significantly higher in LZTR1-mutant patients than SMARCB1-mutant patients, which should be considered for development of disease models and targeted therapies. The anatomic limitations of WBMRI will be addressed in future studies by the addition of dedicated neuraxis imaging. Larger studies of schwannomatosis patients are needed to refine these preliminary observations.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Jordan, J., Smith, M., Merker, V., Cai, W., Harris, G., Bredella, M., Erdin, S., Gusella, J., Plotkin, S. Tags: NEURO-IMAGING Source Type: research

Qlif-24. assessing the beneficial impacts of the neuro-oncology hospitalist practice model: pilot run at uc irvine
CONCLUSION:This new inpatient neuro-oncology hospitalist practice model has shown benefits for our neuro-onc patients and the hospital: it shortens the length of stay, increases DRG score, satisfaction of the patient, family, and the variety of the primary and other consulting services. Benefits of this model over a longer period shall be further investigated.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Kong, X.-T., Fu, D. Tags: QUALITY OF LIFE Source Type: research

Stmc-23. ethical perspectives on unproven stem cell transplants in neuro-oncological disease
The application of stem cell transplants in clinical practice has become increasingly common, and many neurological diseases, including malignant brain tumors, are being targeted for intervention with stem cell transplants. The transplant procedures currently being carried out are frequently unregulated and may endanger patients. In most cases, patients undergoing such operations are not included in a clinical trial, and often do not provide genuinely informed consent. We performed a systematic search of the PubMed database to identify articles that referenced the use of the ethics of stem cell transplants in the treatment...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Cote, D., Smith, T., Bredenoord, A., Broekman, M. Tags: STEM CELLS Source Type: research

Surg-29. personalizing the decision gross total resection (gtr) in neuro-oncology
CONCLUSION:Our study suggest that surgeons should take tumor histopathology into account when deciding upon the extent of surgical resection of glial tumors and the critical need for real-time intra-operative histologic diagnosis.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Chen, C., Alattar, A., Schupper, A., Brandel, M., Padwal, J., Hirshman, B., Carter, B. Tags: SURGICAL THERAPY Source Type: research

Surg-41. "journal bias" in neuro-oncology: an analysis of the surgical high grade glioma literature
CONCLUSIONS:We termed the tendency of certain types of articles to be published in select journals "journal bias" and discuss the implication of this form of bias as it pertains to evidence-based medicine.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Hirshman, B., Jones, L., Tang, J., Ali, M. A., Proudfoot, J., Carley, K., Carter, B., Chen, C. Tags: SURGICAL THERAPY Source Type: research

A Profile of Neuro-Ophthalmic Practice Around the World
Conclusions: Individual national health care system designs and compensation models have had a profound influence on the rewards and challenges that face neuro-ophthalmologists. There seems to have been a connection between recognition of the discipline, financial rewards of neuro-ophthalmic practice, conditions that permit full-time neuro-ophthalmic practice, and patient access to care. A higher percentage of gross national product for health care did not seem to insure an adequate supply of neuro-ophthalmologists.
Source: Journal of Neuro-Ophthalmology - February 21, 2018 Category: Opthalmology Tags: Original Contribution Source Type: research

The relationship of study and authorship characteristics on trial sponsorship and self-reported conflicts of interest among neuro-oncology clinical trials
ConclusionsThe majority of CNS CT reported some external funding sources and non-related COI. We identified that drug trials, higher IF, presence of COI, and a neutral or negative study conclusion are associated with external funding. Likewise drug trials, higher IF, and glioma trials are associated with presence of COI.
Source: Journal of Neuro-Oncology - June 4, 2018 Category: Cancer & Oncology Source Type: research

NMDA receptor dependence of reversal learning and the flexible use of cognitively demanding search strategies in mice
In conclusion, NMDA receptors appear to be involved in the flexible cognitive processes that underlie reversal learning in spatial as well as non-spatial tasks. Our results also indicate that reversal learning as well as the use of cognitively demanding strategies are more sensitive to NMDA receptor blockage than some other functions that have been suggested to be NMDA receptor dependent.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 6, 2018 Category: Psychiatry Source Type: research

Factors Affecting Ophthalmology Resident Choice to Pursue Neuro-Ophthalmology Fellowship Training
Conclusions: There are a variety of factors influencing decisions regarding pursuing neuro-ophthalmology fellowship among ophthalmology residents. The perceived lack of surgical opportunities in neuro-ophthalmology is a deterrent for many. However, a significant number of neuro-ophthalmologists continue to perform surgery, including intraocular surgery. Repeated exposure later in residency may provide an opportunity to reconsider the field and to re-emphasize opportunities to remain surgically involved as a neuro-ophthalmologist. Exposure to the practice patterns of recently graduated neuro-ophthalmologists offers resi...
Source: Journal of Neuro-Ophthalmology - February 25, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research

Impact of Covid-19 Pandemic on Neuro-Oncology Multidisciplinary Tumor Board in the Pre-Vaccine Era: the Normandy experience
CONCLUSION: The pre-vaccination era of the COVID19 pandemic did not impact the activity of neuro-oncology multidisciplinary tumor board in the Normandy region. The possible consequences in terms of public health (excess mortality) due to this tumor location should now be investigated.PMID:36870566 | DOI:10.1016/j.neuchi.2023.101429
Source: Neuro-Chirurgie - March 4, 2023 Category: Neurosurgery Authors: Marine Lacaud Arthur Leclerc Florent Marguet Maxime Faisant Paul Lesueur Houria El Ouazzani Fr édéric Di Fiore Chantal Hanzen Evelyne Emery Olivier Langlois Maxime Fontanilles Source Type: research

Sp-04 * international patterns of palliative care in neuro-oncology: a physician survey of members of the asian society of neuro-oncology, the european association of neuro-oncology and the society for neuro-oncology
CONCLUSION: This is the first report describing global differences of PC utilization in neuro-oncology. Significant differences in provider training, culture, access and utilization were mainly found between AO and the US or AO and Europe. PC patterns are more similar in Europe and the US.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Walbert, T., Puduvalli, V., Taphoorn, M. J. B., Taylor, A. R., Jalali, R. Tags: SUPPORTIVE AND PALLIATIVE CARE Source Type: research

A new case definition of Neuro-Inflammatory and Oxidative Fatigue (NIOF), a neuroprogressive disorder, formerly known as chronic fatigue syndrome or Myalgic Encephalomyelitis: results of multivariate pattern recognition methods and external validation by neuro-immune biomarkers.
Authors: Maes M Abstract BACKGROUND: Chronic fatigue syndrome (CFS) or Myalgic Encephalomyelitis (ME) is characterized by neuro-psychiatric (e.g. depression, irritability, sleep disorders, autonomic symptoms and neurocognitive defects) and physio-somatic (fatigue, a flu-like malaise, hyperalgesia, irritable bowel, muscle pain and tension) symptoms. New ME/CFS case definitions based on consensus criteria among experts are largely inadequate, e.g. those of the US Institute of Medicine . OBJECTIVES: The aim of the present study was to delineate a new case definition of ME/CFS based on pattern recognition methods a...
Source: Neuroendocrinology Letters - October 12, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Epid-16. outcomes of funded neuro-oncology summer research opportunities for medical students
CONCLUSIONS:Compared to historical practice patterns, medical students who participated in neuro-oncology funded summer research opportunities are more likely to be in academia and the neuro-oncology-related fields of neurosurgery, neurology, pathology, and radiation oncology. Early funding for mentored medical student research may provide substantial ‘returns-on-investment’ in terms of future neuro-oncologic research and practice.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Iorgulescu, J. B., Young, G., Kahl, N., Patil, A., Smith, T. Tags: EPIDEMIOLOGY Source Type: research

Telemedicine for neuro-ophthalmology: challenges and opportunities
Purpose of review Telemedicine for neuro-ophthalmology (tele-neuro-ophthalmology) has the potential to increase access to neuro-ophthalmic care by improving efficiency and decreasing the need for long-distance travel for patients. Requirements for decreased person-to-person contacts during the COVID-19 pandemic accelerated adoption of tele-neuro-ophthalmology. This review highlights the challenges and opportunities with tele-neuro-ophthalmology. Recent findings Tele-neuro-ophthalmology programs can be used for triage, diagnostic consultation, and long-term treatment monitoring. Formats include telephone appointm...
Source: Current Opinion in Neurology - January 21, 2021 Category: Neurology Tags: NEURO-OPHTHALMOLOGY: Edited by Heather E. Moss Source Type: research

Proposed definition of competencies for surgical neuro-oncology training
Conclusions and RelevanceThe present work should subsequently initiate a discussion about the proposed competencies and EPAs and, together with the following discussion, contribute to the creation of new training concepts in surgical neuro-oncology.
Source: Journal of Neuro-Oncology - April 21, 2021 Category: Cancer & Oncology Source Type: research