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Sm-08 * neuro-oncological patients admitted in intensive-care unit (icu): patient's characteristics, predictive factors of death in icu and functional outcome
CONCLUSION: In patient with malignant brain tumor,admitted in ICU, predictive factors of death appear to be similar to those described in non-oncological patients. ICU hospitalization is generally not associated with a subsequent decrease of functional status.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Tabouret, E., Boucard, C., Barrie, M., Autran, D., Bruder, N., Chinot, O. Tags: SYMPTOM MANAGEMENT Source Type: research

Treatment of Neuro-Ophthalmic Sarcoidosis
Conclusions: Although methotrexate and mycophenolate mofetil are the medications that are often selected after corticosteroid failure, more rapidly acting agents that have been used are infliximab and intravenous cyclophosphamide.
Source: Journal of Neuro-Ophthalmology - February 26, 2015 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

Randomized controlled trials and neuro-oncology: should alternative designs be considered?
Abstract Deficiencies in design and reporting of randomized controlled trials (RCTs) hinders interpretability and critical appraisal. The reporting quality of recent RCTs in neuro-oncology was analyzed to assess adequacy of design and reporting. The MEDLINE and EMBASE databases were searched to identify non-surgical RCTs (years 2005–2014, inclusive). The CONSORT and Jadad scales were used to assess the quality of design/reporting. Studies published in 2005–2010 were compared as a cohort against studies published in 2011–2014, in terms of general characteristics and reporting quality. A PRECIS-based scale was...
Source: Journal of Neuro-Oncology - August 21, 2015 Category: Cancer & Oncology Source Type: research

Future directions of operative neuro-oncology
Abstract Recent technological advancements have drastically improved the safety and surgical precision of operative neuro-oncology. These include techniques for avoiding critical functional structures through pre-operative mapping and trajectory planning, as well the development and refinement of minimally invasive surgical approaches. Innovations in intra-operative tumor mapping, and post-resection tumor ablation have further combined to improve surgical outcomes. This review highlights such advancements and discusses future directions within operative neuro-oncology.
Source: Journal of Neuro-Oncology - June 21, 2016 Category: Cancer & Oncology Source Type: research

Pall-06. improving patient outcomes through a multidisciplinary neuro-oncology rehabilitation clinic
DISCUSSION:This multidisciplinary approach was developed to increase timely rehabilitation services to patients with complex needs. Treated patients were highly debilitated with substantial functional deficits and reduced quality of life. Patients reported high levels of satisfaction with the intervention and felt well educated. There was a trend towards improved answers on the fall questionnaires post-intervention over time. Further evaluation investigating quality of life impact is ongoing.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Mohler, A., Callan, A., Peter, R., Palmer, L., Ney, D. Tags: SUPPORTIVE PALLIATIVE CARE Source Type: research

Pdtb-27. precision medicine in pediatric neuro-oncology
CONCLUSION:We strongly encourage patients to enroll in our precision medicine pathway. The WES platform capture reads for over 20,000 genes and offers a unique data set that may shed light on both known cancer relevant somatic alterations but also functional relevance for less known mutations on a case-specific basis.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Rajappa, P., Pisapia, D. Tags: PEDIATRIC TUMORS - PRECLINICAL STUDIES (NON-IMMUNOLOGICAL) Source Type: research

Qlif-14. quality improvement and practice based research in neuro-oncology using the electronic medical record
CONCLUSIONS:The EMR can be effectively structured to standardize Neuro-oncology office visits, capture data, and support multicenter quality improvement and practice based research initiatives.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Merrell, R., Martinez, N., Stasinos, S., Muresan, J., Walters, S., Amelse, L., Glatman, I., Dudek, M., Patel, V., Frigerio, R., Maraganore, D. Tags: QUALITY OF LIFE Source Type: research

Surg-30. using the neurologic assessment in neuro-oncology (nano) scale as a predictive assessment tool for survival in patients with primary glioblastoma
The neurologic assessment in neuro-oncology (NANO) scale is a standardized metric designed to measure neurologic function in neuro-oncology. Current available neuroradiological evaluation criteria fail to use specific clinical criteria for tumor recurrence. Additionally, existing clinical measures of patient performance such as the Karnofsky Performance Scale (KPS) and the Eastern Cooperative Oncology Group (ECOG) are generalized and do not incorporate specific neurologic performance criteria in assessment of the patient, nor are they used to predict glioma progression. Currently, it is not known whether or not the NANO sc...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Ung, T., Ney, D., Damek, D., Yousseff, S., Lillehei, K., Ormond, D. Tags: SURGICAL THERAPY Source Type: research

Exablate Neuro for Essential Tremor
Date: March 27, 2017 Issue #:  1517Summary:  The FDA has approved use ofExablate Neuro (Insightec) for unilateral thalamotomy to treat medication-refractory essential tremor in patients≥22 years old.Exablate Neuro uses magnetic resonance-guided focused ultrasound (MRgFUS) to create lesions in the ventral intermediate nucleus of the thalamus. MRgFUS is also approved in the US for treatment of uterine fibroids and for pain palliation of bone metastases.
Source: The Medical Letter - February 22, 2017 Category: Drugs & Pharmacology Authors: admin Tags: Botulinum toxin essential tremor Exablate Neuro Inderal Mysoline Primidone Propranolol Topamax topiramate Source Type: research

Integra LifeSciences, Johnson & Johnson pass papers on $1B Codman Neuro buy
Integra LifeSciences (NSDQ:IART) said yesterday that it passed papers with Johnson & Johnson (NYSE:JNJ) last week on its $1.05 billion cash bid for J&J’s Codman Neurosurgery unit. Completing the deal still hinges on the expiration of the Hart-Scott-Rodino waiting period and antitrust approvals in Spain and the U.K., Integra said in a regulatory filing. When it announced the deal in February, Plainsboro, N.J.-based Integra has said it plans to finance the buyout with cash on hand, a credit revolver and a new term loan; BofA Merrill Lynch and JPMorgan are backing the deal. Codman Neuro put up sales of about...
Source: Mass Device - May 16, 2017 Category: Medical Devices Authors: Brad Perriello Tags: Mergers & Acquisitions Neurological Wall Street Beat Codman Neuro Integra LifeSciences Corp. johnsonjohnson Source Type: news

The use of optical coherence tomography in neuro-ophthalmology
Purpose of review In the last decade, with the advances of optical coherence tomography (OCT) technology, different imaging protocols and analysis algorithms have been introduced to maximize the potential of this diagnostic tool in the evaluation of different eye diseases. This review aims to provide an update on these additional features, with respect to the management of a diverse range of neuro-ophthalmologic conditions. Recent findings Macular ganglion cell complex (mGCC) analysis has been shown to be superior to peripapillary retinal nerve fiber layer (pRNFL) analysis in certain settings, such as differentiating Lebe...
Source: Current Opinion in Ophthalmology - October 12, 2017 Category: Opthalmology Tags: NEURO-OPHTHALMOLOGY: Edited by Dean M. Cestari Source Type: research

Arquivos de Neuro-Psiquiatria: 75 years
ABSTRACT This year marks the 75th year of publication of Arquivos de Neuro-Psiquiatria (ANP), the official journal of the Brazilian Academy of Neurology and one of the most important neuroscience journals in Latin America. ANP was initially edited by Oswaldo Lange, its founder, and subsequently by Antonio Spina-Fran ça Netto and, in recent years, by José Antonio Livramento and Luís dos Ramos Machado.RESUMO Arquivos de Neuro-Psiquiatria (ANP), o peri ódico oficial da Academia Brasileira de Neurologia, completou 75 anos de atividades, reconhecido como um dos jornais de neurociências mais importante da América Latina. N...
Source: Arquivos de Neuro-Psiquiatria - January 22, 2018 Category: Neurology Source Type: research

Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Gouri J. Mahajan, Eric J. Vallender, Michael R. Garrett, Lavanya Challagundla, James C. Overholser, George Jurjus, Lesa Dieter, Maryam Syed, Damian G. Romero, Hamed Benghuzzi, Craig A. Stockmeier Major Depressive Disorder (MDD) is a common psychiatric disorder for which available medications are often not effective. The high prevalence of MDD and modest response to existing therapies compels efforts to better understand and treat the disorder. Decreased hippocampal volume with increasing duration of d...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Neuro-MIG: A European network on brain malformations.
PMID: 30053454 [PubMed - as supplied by publisher]
Source: European Journal of Medical Genetics - July 24, 2018 Category: Genetics & Stem Cells Authors: Mancini GMS, Neuro-MIG Network (COST Action CA16118) Tags: Eur J Med Genet Source Type: research

Neuro-ophthalmic complications of IgG4-related disease
Purpose of review IgG4-related disease (IgG4-RD) is increasingly recognized as a fibroinflammatory disease with a plethora of organ-specific manifestations but a particular predilection for head and neck tissues, including the nervous system. This review discusses general features and organ-specific presentations of IgG4-RD as well as treatment considerations, particularly emphasizing features of neuro-ophthalmic interest. Recent findings IgG4-RD is emerging as a common cause of several fibroinflammatory disorders in the head and neck that were previously considered idiopathic, such as sclerosing orbital pseudotumor, ...
Source: Current Opinion in Ophthalmology - October 5, 2018 Category: Opthalmology Tags: NEURO-OPHTHALMOLOGY: Edited by Dean M. Cestari Source Type: research