Spirituality and heart failure: a systematic review
CONCLUSIONS: Despite the extreme heterogeneity of the populations included, of the definition of spirituality and religiosity, and of the interventions in the few studies that included it, all the studies reported some positive associations with the outcomes examined. Spirituality/religiosity is an aspect not generally taken into account in the usual practice of medicine and can potentially contribute to improving the conditions of patients with HF, a chronic disease with unfavorable prognosis.PMID:37737928 | DOI:10.1007/s40520-023-02557-x
Source: Aging Clinical and Experimental Research - September 22, 2023 Category: Geriatrics Authors: Laura Cilona Nicola Veronese Diego Lalicata Francesca Tantillo Liliana Naro Ligia J Dominguez Mario Barbagallo Source Type: research

Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis
Biogerontology. 2023 Sep 22. doi: 10.1007/s10522-023-10064-9. Online ahead of print.ABSTRACTAccumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling due to aging-related secretory phenotypes have been hypothesized to cause age-related skin aging, which results in wrinkles and loss of skin elasticity, thus compromising appearance attractiveness. However, the rejuvenating effects of removing senescent cells from the human skin and the efficacy of related therapeutic agents remain unclear. Here, we investigated the effects of fisetin, a potential anti-aging component found in various edible fruits ...
Source: Biogerontology - September 22, 2023 Category: Geriatrics Authors: Kento Takaya Toru Asou Kazuo Kishi Source Type: research

Older Men, The Patient-Physician Relationship, and Patient Involvement
This study investigates older men's experiences with physicians, their perceptions of the patient-physician relationship, and the extent to which they wished to be involved in their health care. In-depth, face-to-face interviews were conducted with 23 men 55-96 years of age. Findings reveal that older men want to participate in the medical encounter and be involved in their care, contradicting earlier work suggesting that older adults prefer to be passive patients. Preferred involvement, however, varied along a continuum ranging from "quasi-involvement" to "taking charge", with most participants being in the middle, prefer...
Source: Canadian Journal on Aging - September 22, 2023 Category: Geriatrics Authors: Hazel MacRae Source Type: research

Type 2 diabetes mellitus increases postoperative recurrence risk in Chinese patients with chronic rhinosinusitis
CONCLUSIONS: Elevated FBG levels may significantly influenced the postoperative recurrence of CRS in Chinese patients, and T2DM was an independent risk factor for recurrence.PMID:37737711 | DOI:10.1080/00016489.2023.2255222
Source: Acta Oto-Laryngologica - September 22, 2023 Category: ENT & OMF Authors: Mengfei Luo En Zhou Fusen Peng Source Type: research

Determining optimal cochlear implant electrode array with OTOPLAN
CONCLUSION AND SIGNIFICANCE: Our findings revealed that CDL varies widely, which is consistent with previous studies. To achieve better speech perception, surgeons should select the appropriate length of CI electrode array based on the individual's CDL. Preoperative measurement of each CDL by OTOPLAN, which is clinically feasible and comparable to postoperative evaluation, can be used to ensure selection of the appropriate electrode array length.PMID:37737708 | DOI:10.1080/00016489.2023.2256790
Source: Acta Oto-Laryngologica - September 22, 2023 Category: ENT & OMF Authors: Hidekane Yoshimura Kizuki Watanabe Shin-Ya Nishio Yutaka Takumi Shin-Ichi Usami Source Type: research

Self-reported symptoms of laryngopharyngeal reflux using the reflux symptom score in patients with obstructive sleep apnea syndrome
CONCLUSION: The results of this investigation indicate that the prevalence of LPR-related symptoms is higher using the RSS in comparison to the RSI.PMID:37737706 | DOI:10.1080/00016489.2023.2258160
Source: Acta Oto-Laryngologica - September 22, 2023 Category: ENT & OMF Authors: Abdul-Latif Hamdan Jerome R Lechien Anthony Ghanem Patrick Abou Raji Feghali Jad Hosri Elie Alam Source Type: research

Clinical correlation research of 3D reconstruction of retrolabyrinthine space based on HRCT of temporal bone
Conclusions and Significance: 3D reconstruction of CT images clearly displayed the detailed structures of the temporal bone. Surgical adaptability of the retrolabyrinthine approach can be assessed preoperatively by image and other methods, and anatomical parameters play an important role in the retrolabyrinthine space. Therefore, this study helps to skeleton the bone as much as possible to expand the surgical space, so that the surgeon can contact the anatomical structure more diversified to expand the surgical indications.PMID:37737694 | DOI:10.1080/00016489.2023.2255642
Source: Acta Oto-Laryngologica - September 22, 2023 Category: ENT & OMF Authors: Lu Xing Gaogan Jia Hailiang Lin Yusu Ni Source Type: research

Anti-craving Medications for Alcohol Use Disorder Treatment in the Emergency Department: A Systematic Review of Direct Evidence for SEAM GRACE
CONCLUSIONS: Overall, there are few studies directly examining the efficacy of anti-craving medication for AUD in the ED, although the limited evidence that exists is supportive of naltrexone pharmacotherapy, particularly extended-release injection formulation. Additional randomized controlled trials (RCTs) are necessary for substantive direct evidence on anti-craving medication initiation in the ED.PMID:37735346 | DOI:10.1111/acem.14806
Source: Accident and Emergency Nursing - September 22, 2023 Category: Emergency Medicine Authors: Kiran Punia William Scott Kriti Manuja Monica Sabbineni Kaitryn Campbell Iris M Balodis James MacKillop Source Type: research

Artificial Intelligence for Drug Discovery: Are We There Yet?
Annu Rev Pharmacol Toxicol. 2023 Sep 22. doi: 10.1146/annurev-pharmtox-040323-040828. Online ahead of print.ABSTRACTDrug discovery is adapting to novel technologies such as data science, informatics, and artificial intelligence (AI) to accelerate effective treatment development while reducing costs and animal experiments. AI is transforming drug discovery, as indicated by increasing interest from investors, industrial and academic scientists, and legislators. Successful drug discovery requires optimizing properties related to pharmacodynamics, pharmacokinetics, and clinical outcomes. This review discusses the use of AI in ...
Source: Pharmacological Reviews - September 22, 2023 Category: Drugs & Pharmacology Authors: Catrin Hasselgren Tudor I Oprea Source Type: research

Mass Spectrometry-Based Proteogenomics: New Therapeutic Opportunities for Precision Medicine
Annu Rev Pharmacol Toxicol. 2023 Sep 22. doi: 10.1146/annurev-pharmtox-022723-113921. Online ahead of print.ABSTRACTProteogenomics refers to the integration of comprehensive genomic, transcriptomic, and proteomic measurements from the same samples with the goal of fully understanding the regulatory processes converting genotypes to phenotypes, often with an emphasis on gaining a deeper understanding of disease processes. Although specific genetic mutations have long been known to drive the development of multiple cancers, gene mutations alone do not always predict prognosis or response to targeted therapy. The benefit of p...
Source: Pharmacological Reviews - September 22, 2023 Category: Drugs & Pharmacology Authors: Sunil K Joshi Paul Piehowski Tao Liu Sara J C Gosline Jason E McDermott Brian J Druker Elie Traer Jeffrey W Tyner Anupriya Agarwal Cristina E Tognon Karin D Rodland Source Type: research

The ASHP House of Delegates: Reflecting on 75 years of advancing health
Am J Health Syst Pharm. 2023 Sep 21:zxad227. doi: 10.1093/ajhp/zxad227. Online ahead of print.ABSTRACTIn an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.PMID:37738619 | DOI:10.1093/ajhp/zxad227
Source: American Journal of Health-System Pharmacy : AJHP - September 22, 2023 Category: Drugs & Pharmacology Authors: Daniel J Cobaugh Source Type: research

Orthodontic Management of Severe Hypodontia and Impacted Maxillary Second Molars in a Patient with Sotos Syndrome
Cleft Palate Craniofac J. 2023 Sep 21:10556656231201834. doi: 10.1177/10556656231201834. Online ahead of print.ABSTRACTSotos syndrome is a genetic disorder characterized by distinct craniofacial features, overgrowth in childhood, and impaired intellectual development. We herein report the successful orthodontic treatment of a 14-year-old boy with Sotos syndrome caused by a heterozygous mutation in the NSD1 gene. He showed severe hypodontia, impaction of the maxillary second molars and a skeletal Class III jaw-base relationship. Orthodontic management, including space control by protraction of the maxillary first molars and...
Source: The Cleft Palate-Craniofacial Journal - September 22, 2023 Category: ENT & OMF Authors: Ayaka Oka Toshihiro Inubushi Renshiro Kani Takashi Yamashiro Source Type: research

NKG2A discriminates natural killer cells with a suppressed phenotype in pediatric acute leukemia
In conclusion, high expression of NKG2A dominates NK cell phenotypes from pediatric BCP-ALL patients, indicating that NKG2A could be targeted in therapies for this patient group.PMID:37738462 | DOI:10.1093/jleuko/qiad112
Source: Journal of Leukocyte Biology - September 22, 2023 Category: Hematology Authors: Aina Ulvmoen Victor Greiff Anne G Bechensteen Marit Inngjerdingen Source Type: research

Clinical significance of human neutrophil antigen-1 antibodies in children with neutropenia
This study analyzed the clinical characteristics of 402 children with neutropenia to identify differences between those with and without HNA-1 antibodies (HNA1abs). HNAabs in sera were detected by granulocyte immunofluorescence testing using flow cytometry. Relative fluorescence intensity (RFI) values were used to divide patients into positive (PG, n = 302), borderline (BG, n = 34), and negative (NG, n = 66) groups. The antibodies reacted to HNA-1a alone (59%), HNA-1b alone (1%), and HNA-1a/1b (40%). The PG had a significantly lower absolute neutrophil count before definitive diagnosis and a 1.6- to 2-times greater risk of...
Source: International Journal of Hematology - September 22, 2023 Category: Hematology Authors: Satoshi Goda Shuhei Karakawa Satoshi Okada Hiroshi Kawaguchi Emi Kurita Mitsunori Noma Aiko Yamaoka Mayumi Komatsu Ayaka Yanai Mayu Kashihara Teruhisa Fujii Rie Onodera Kikuyo Taniguchi Mika Aizawa Masao Kobayashi Source Type: research

Association of Circulating Very Long Chain Saturated Fatty Acids with Cardiovascular Mortality in NHANES 2015-2016
CONCLUSION: Our results confirm the protective effect of high levels of circulating VLSFAs (C22:0 and C24:0) on CVD, CHD and all-cause of death in the whole, hyperlipidemia and hypertensive populations.PMID:37738581 | DOI:10.1210/clinem/dgad561
Source: The Journal of Clinical Endocrinology and Metabolism - September 22, 2023 Category: Endocrinology Authors: Xinmiao Tao Lin Liu Pingnan Ma Jinxia Hu Zhu Ming Keke Dang Yuntao Zhang Ying Li Source Type: research

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