First Author Highlights
Am J Physiol Renal Physiol. 2023 Oct 1;325(4):i-ii. doi: 10.1152/ajprenal.2023.325.4.AU.NO ABSTRACTPMID:37738000 | DOI:10.1152/ajprenal.2023.325.4.AU
Source: American Journal of Physiology. Renal Physiology - September 22, 2023 Category: Physiology Source Type: research

An exploration of ex-boarding school adults' attachment styles and substance use behaviours
Attach Hum Dev. 2023 Sep 22:1-15. doi: 10.1080/14616734.2023.2228761. Online ahead of print.ABSTRACTOur study examines the relationship between boarding school attendance, adult attachment styles, parental bonding, and substance use, aiming was to quantitatively investigate if caregiver deprivation caused by boarding contributes to enduring outcomes in adults. In a sample of 149 adults, measures included AUDIT and DUDIT (substance use), Parental Bonding Instrument (parental care), and Experiences in Close Relationships (adult attachment). Pearson's correlation revealed a significant negative association between age at firs...
Source: Attachment and Human Development - September 22, 2023 Category: Child Development Authors: Natalie Wharton Mariel Marcano-Olivier Source Type: research

Pharmacological inhibition of S6K1 rescues synaptic deficits and attenuates seizures and depression in chronic epileptic rats
CONCLUSION: In conclusion, our data suggest that inhibition of S6K1 attenuates seizures and depression in chronic epileptic rats via the rescue of synaptic structural and functional deficits. Given the wide range of physiological functions of mTOR, inhibition of its effective but relatively simple functional downstream molecules is a promising target for the development of drugs for epilepsy.PMID:37736829 | DOI:10.1111/cns.14475
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Yuying Zhang Xiaojuan Cheng Luyan Wu Juan Li Changyun Liu Mingjia Wei Chaofeng Zhu Huapin Huang Wanhui Lin Source Type: research

The prevalence and risk factors study of cognitive impairment: Analysis of the elderly population of Han nationality in Hunan province, China
CONCLUSION: A representative prevalence of cognitive impairment, MCI, and dementia was found in the elderly Han Chinese population in Southern China. And we further explored the role of known risk factors, particularly in physical activity, smoking, and alcohol consumption.PMID:37736696 | DOI:10.1111/cns.14478
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Tianyan Xu Guiwen Bu Li Yuan Lu Zhou Qijie Yang Yuan Zhu Sizhe Zhang Qianqian Liu Ziyu Ouyang Xuan Yang Beisha Tang Bin Jiao Yuzhang Bei Lu Shen Source Type: research

Melatonin regulates the circadian rhythm to ameliorate postoperative sleep disorder and neurobehavioral abnormalities in aged mice
CONCLUSIONS: Melatonin receptors in SCN, circadian rhythm, and ERK/CREB signaling pathway participate in the pathophysiological processes of PSD and delirium-like behavior. Melatonin intervention could be a potential preventative approach for PSD and delirium.PMID:37736695 | DOI:10.1111/cns.14436
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Xixi Jia Yanan Song Zhengqian Li Ning Yang Taotao Liu Dengyang Han Zhuonan Sun Chengmei Shi Yang Zhou Jie Shi Yajie Liu Xiangyang Guo Source Type: research

NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease
CONCLUSIONS: This review provides a future diagnosis and treatment strategy for AD patients based on ncRNAs.PMID:37735992 | DOI:10.1111/cns.14476
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Liangxian Li Mingyue Jin Jie Tan Bo Xiao Source Type: research

Rasd1 is involved in white matter injury through neuron-oligodendrocyte communication after subarachnoid hemorrhage
CONCLUSIONS: It can be concluded that Rasd1 exerts a modulated role in oligodendrocytes ferroptosis in WMI following SAH.PMID:37735980 | DOI:10.1111/cns.14452
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Wenqiao Fu Xudong Che Jiahe Tan Shizhen Cui Yinrui Ma Daiqi Xu Haibo Long Xiaolin Yang Tangmin Wen Zhaohui He Source Type: research

NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m < sup > 6 < /sup > A methylation through upregulation of METTL3 transcription
CONCLUSION: Conclusively, NRF1 constrained motor dysfunction and dopamine neuron degeneration in MPTP-induced PD mice by activating the METTL3/GLRX axis.PMID:37735974 | DOI:10.1111/cns.14441
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Xin Gong Mengyi Huang Lei Chen Source Type: research

Potential risk factors and genetic variants associated with dental caries incidence in Appalachia using genome-wide survival analysis
CONCLUSION: Our findings indicate that household income, home water source, and mother's educational attainment are independent risk factors for dental caries incidence. We nominate several suggestive loci for further investigation.PMID:37736056 | PMC:PMC10509536
Source: International Journal of Molecular Epidemiology and Genetics - September 22, 2023 Category: Genetics & Stem Cells Authors: Tianyu Zou Katherine Neiswanger Eleanor Feingold Betsy Foxman Daniel W McNeil Mary L Marazita John R Shaffer Source Type: research

Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons
Cell Mol Neurobiol. 2023 Sep 22. doi: 10.1007/s10571-023-01405-w. Online ahead of print.ABSTRACTTo study key proteins associated with changes in synaptic transmission in the spiral ganglion in tinnitus, we build three gene lists from the GeneCard database: 1. Perception of sound (PoS), 2. Acoustic stimulation (AcouStim), and 3. Tinnitus (Tin). Enrichment analysis by the DAVID database resulted in similar Gene Ontology (GO) terms for cellular components in all gene lists, reflecting synaptic structures known to be involved in auditory processing. The STRING protein-protein interaction (PPI) network and the Cytoscape data an...
Source: Cellular and Molecular Neurobiology - September 22, 2023 Category: Cytology Authors: Johann Gross Marlies Knipper Birgit Mazurek Source Type: research

EGR1 Promotes Ovarian Hyperstimulation Syndrome Through Upregulation of SOX9 Expression
This study aimed to investigate the function and mechanism of EGR1 involved in OHSS progression. RNA-sequencing was used to identify differentially expressed genes. In vitro OHSS cell model was induced by treating KGN cells with human chorionic gonadotropin (hCG). In vivo OHSS model was established in mice. The expression levels of EGR1, SOX1, and VEGF were determined by Quantitative Real-Time polymerase chain reaction (qRT-PCR), Western blot, immunofluorescence staining, and immunochemistry assay. The content of VEGF in the culture medium of human granulosa-like tumor cell line (KGN) cells was accessed by the ELISA assay....
Source: Cell Transplantation - September 22, 2023 Category: Cytology Authors: Huihui Wang Weijia Chen Yinan Huang Yuan Sun Yuanhua Liu Yuanchao Zhu Zongxuan Lu Source Type: research

Muscle synergies are associated with intermuscular coherence and cortico-synergy coherence in an isometric upper limb task
Exp Brain Res. 2023 Sep 22. doi: 10.1007/s00221-023-06706-6. Online ahead of print.ABSTRACTTo elucidate the underlying physiological mechanisms of muscle synergies, we investigated long-range functional connectivity by cortico-muscular (CMC), intermuscular (IMC) and cortico-synergy (CSC) coherence. Fourteen healthy participants executed an isometric upper limb task in synergy-tuned directions. Cortical activity was recorded using 32-channel electroencephalography (EEG) and muscle activity using 16-channel electromyography (EMG). Using non-negative matrix factorisation (NMF), we calculated muscle synergies from two differen...
Source: Experimental Brain Research - September 22, 2023 Category: Neuroscience Authors: Pablo Ortega-Auriol Winston D Byblow Thor Besier Angus J C McMorland Source Type: research

Sleep Spindle Generation Before and After Epilepsy Surgery: A Source Imaging Study in Children with Drug-Resistant Epilepsy
CONCLUSIONS: Our data indicate alterations in the EEG slow spindles after resective epilepsy surgery. Fast spindle generation on the contrary did not change after surgery. Although the study is limited by its retrospective nature, lack of healthy controls, and reduced cortical spatial sampling, our findings suggest a spatial relationship between the slow spindles and the epileptogenic generators.PMID:37737957 | DOI:10.1007/s10548-023-01007-1
Source: Brain Topography - September 22, 2023 Category: Neuroscience Authors: Assia Chericoni Lorenzo Ricci Georgios Ntolkeras Roberto Billardello Scellig S D Stone Joseph R Madsen Christos Papadelis P Ellen Grant Phillip L Pearl Fabrizio Taffoni Alexander Rotenberg Eleonora Tamilia Source Type: research

Reliability of a Newly Developed Tool to Assess and Classify Work-related Stress (TAWS-16)
CONCLUSIONS: TAWS-16 demonstrated acceptable reliability. It measured stressors, coping abilities, and psychosomatic symptoms associated with work stress. We recommend using TAWS-16 to holistically identify work stress among employees during periodical health check-ups in India.PMID:37735832 | DOI:10.3961/jpmph.23.219
Source: Journal of Preventive Medicine and Public Health - September 22, 2023 Category: International Medicine & Public Health Authors: Gautham Melur Sukumar Runalika Roy Mariamma Philip Gopalkrishna Gururaj Source Type: research

Characteristics and Healthcare Spending of Persistently and Transiently High-cost Older Adults in South Korea
CONCLUSIONS: Medical risk factors contribute to high health care spending to some extent, but social risk factors may be a source of persistent high-cost status among older adults in South Korea.PMID:37735830 | DOI:10.3961/jpmph.23.270
Source: Journal of Preventive Medicine and Public Health - September 22, 2023 Category: International Medicine & Public Health Authors: Sungchul Park Giryeon Bae Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20