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Total 14557 results found since Jan 2013.

Families with infants and toddlers in the COVID-19 pandemic: parental stress and child development considering social class
DISCUSSION: In order to mitigate the psychosocial consequences of the COVID-19 pandemic for families and to improve children's chances of growing up in a healthy way that promotes their development, it is necessary to support families in need without stigmatization.PMID:37470841 | PMC:PMC10371926 | DOI:10.1007/s00103-023-03744-x
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - July 20, 2023 Category: International Medicine & Public Health Authors: Ilona Renner Susanne M Ulrich Anna Neumann Digo Chakraverty Source Type: research

Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-expansion stage of a multicentre, open-label, phase I trial
British Journal of Cancer, Published online: 20 July 2023; doi:10.1038/s41416-023-02349-0Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-expansion stage of a multicentre, open-label, phase I trial
Source: British Journal of Cancer - July 20, 2023 Category: Cancer & Oncology Authors: Michael Friedlander Linda Mileshkin Janine Lombard Sophia Frentzas Bo Gao Michelle Wilson Tarek Meniawy Sally Baron-Hay Karen Briscoe Nicole McCarthy Christos Fountzilas Andres Cervantes Ruimin Ge John Wu Alexander Spira Source Type: research

Disposable vapes should be restricted like tobacco in order to clamp down on UK's kid e-cig epidemic, senior Tory MP claims
Steve Brine, chair of the committee, said 'decisive action is needed' from the UK Government and industry to 'tackle an alarming trend in the number of children vaping'.
Source: the Mail online | Health - July 19, 2023 Category: Consumer Health News Source Type: news

Fury over 'insane' call to let pregnant trans men take testosterone despite risk to babies - as woke, Government-funded researchers claim gender-affirming care is more important than having a 'normal' kid
Taxpayer funded experts have controversially claimed medics are too heavily prioritising the health of the foetus in pressuring pregnant trans men to give up their gender bending hormones.
Source: the Mail online | Health - July 19, 2023 Category: Consumer Health News Source Type: news

Nancy Pelosi Mocks Concern Over Biden ’s Age By Noting He’s Younger Than Her: ‘He’s a Kid to Me!’
Former House Speaker Nancy Pelosi (D-CA) noted that 80-year-old Joe Biden was younger than her in an effort to downplay the extent to which the president’s age might hamper his reelection campaign. Asked by Morning Joe‘s Mika Brzezinski what she “made of the criticism that he’s too old to have a…#nancypelosi #mikabrzezinski #democrats #normanlear #frankgehry #msnbcthe #nancypelosimocks #mediaite
Source: Reuters: Health - July 19, 2023 Category: Consumer Health News Source Type: news

Here ' s How to Make Summer Sports Camp a Safe Adventure for Your Kid
WEDNESDAY, July 19, 2023 -- If your child is in sports camp this summer, you ’ll want them to have fun and stay safe. The National Athletic Trainers’ Association (NATA) offers some tips on dealing with existing medical conditions, staying...
Source: Drugs.com - Daily MedNews - July 19, 2023 Category: General Medicine Source Type: news

The New Fat Kid on the Block: Lipoprotein (a)
This report aims to raise awareness about the significance of elevated Lp(a) levels in contributing to atherosclerotic cardiovascular disease and major adverse cardiovascular events and to assist nurse practitioners in using evidence-based approaches to lower its levels. We synthesized recommendations for managing elevated Lp(a) concentrations using the Canadian, United States, and European study guidelines.
Source: The Journal for Nurse Practitioners - July 19, 2023 Category: Nursing Authors: Mohamed Toufic El Hussein, Sasha Lewis Tags: Featured Article Source Type: research

Measuring cognitive flexibility in anorexia nervosa: Wisconsin Card Sorting Test versus cued task-switching
CONCLUSIONS: Results provide support for previous suggestions that WCST perseverative errors could occur due to difficulties with working memory, sensitivity to feedback, and issues with concept formation. Cued task-switching paradigms may provide a useful measure of cognitive flexibility for future eating disorders research by reducing task-specific confounds.LEVEL OF EVIDENCE: Level III Case-control analytic study.PMID:37463996 | PMC:PMC10354129 | DOI:10.1007/s40519-023-01589-6
Source: Eating and weight disorders : EWD - July 18, 2023 Category: Eating Disorders & Weight Management Authors: Kelly M Dann Aaron Veldre Stephanie Miles Philip Sumner Phillipa Hay Stephen Touyz Source Type: research

Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
Cell Metab. 2023 Jul 11:S1550-4131(23)00223-1. doi: 10.1016/j.cmet.2023.06.013. Online ahead of print.ABSTRACTLactate was implicated in the activation of hepatic stellate cells (HSCs). However, the mechanism by which lactate exerts its effect remains elusive. Using RNA-seq and CUT&Tag chromatin profiling, we found that induction of hexokinase 2 (HK2) expression in activated HSCs is required for induced gene expression by histone lactylation but not histone acetylation. Inhibiting histone lactylation by Hk2 deletion or pharmacological inhibition of lactate production diminishes HSC activation, whereas exogenous lactate ...
Source: Cell Metabolism - July 18, 2023 Category: Cytology Authors: Hyunsoo Rho Alexander R Terry Constantinos Chronis Nissim Hay Source Type: research

Measuring cognitive flexibility in anorexia nervosa: Wisconsin Card Sorting Test versus cued task-switching
CONCLUSIONS: Results provide support for previous suggestions that WCST perseverative errors could occur due to difficulties with working memory, sensitivity to feedback, and issues with concept formation. Cued task-switching paradigms may provide a useful measure of cognitive flexibility for future eating disorders research by reducing task-specific confounds.LEVEL OF EVIDENCE: Level III Case-control analytic study.PMID:37463996 | DOI:10.1007/s40519-023-01589-6
Source: Eating and weight disorders : EWD - July 18, 2023 Category: Eating Disorders & Weight Management Authors: Kelly M Dann Aaron Veldre Stephanie Miles Philip Sumner Phillipa Hay Stephen Touyz Source Type: research

Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
Cell Metab. 2023 Jul 11:S1550-4131(23)00223-1. doi: 10.1016/j.cmet.2023.06.013. Online ahead of print.ABSTRACTLactate was implicated in the activation of hepatic stellate cells (HSCs). However, the mechanism by which lactate exerts its effect remains elusive. Using RNA-seq and CUT&Tag chromatin profiling, we found that induction of hexokinase 2 (HK2) expression in activated HSCs is required for induced gene expression by histone lactylation but not histone acetylation. Inhibiting histone lactylation by Hk2 deletion or pharmacological inhibition of lactate production diminishes HSC activation, whereas exogenous lactate ...
Source: Cell Metabolism - July 18, 2023 Category: Cytology Authors: Hyunsoo Rho Alexander R Terry Constantinos Chronis Nissim Hay Source Type: research

Concussions Won ' t Lower Your Kid ' s IQ: Study
MONDAY, July 17, 2023 -- If your child has ever taken a knock to the head on the playing field, a new study has some reassuring news: There ' s no evidence that a concussion shaves points from a kid ' s IQ. Researchers found that compared with children...
Source: Drugs.com - Daily MedNews - July 17, 2023 Category: General Medicine Source Type: news

Acute Myeloid Leukemia Treatment in the Elderly: A Comprehensive Review of the Present and Future
This article reviews past and current treatment strategies that harness various mechanisms of leukemia-targeting agents and introduces novel therapies on the horizon aimed at exploring therapeutic options for elderly and unfit patient population. It also provides a strategy to select the best available therapy for elderly patients with both newly diagnosed and relapsed/refractory AML.PMID:37459852 | DOI:10.1159/000531628
Source: Acta Haematologica - July 17, 2023 Category: Hematology Authors: Jun Choi Mihir Shukla Maher Abdul-Hay Source Type: research