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Acute Myeloid Leukemia Treatment in the Elderly: A Comprehensive Review of the Present and Future
This article reviews past and current treatment strategies that harness various mechanisms of leukemia-targeting agents and introduces novel therapies on the horizon aimed at exploring therapeutic options for elderly and unfit patient population. It also provides a strategy to select the best available therapy for elderly patients with both newly diagnosed and relapsed/refractory AML.PMID:37459852 | DOI:10.1159/000531628
Source: Acta Haematologica - July 17, 2023 Category: Hematology Authors: Jun Choi Mihir Shukla Maher Abdul-Hay Source Type: research

The impact of busulfan on the testicular structure in prepubertal rats: A histological, ultrastructural and immunohistochemical study
Ultrastruct Pathol. 2023 Jul 16:1-27. doi: 10.1080/01913123.2023.2234470. Online ahead of print.ABSTRACTBusulfan is a widely used cancer chemotherapeutic agent. Temporary or permanent sterility in male patients is one of the most common side effects of this drug. The present study was performed to evaluate the changes in the microscopic structure of the testes of prepubertal rats, as well as the changes in PCNA and caspase-3 immune expression, at different durations after busulfan administration. The rats were 5 weeks old and were divided into two main groups. Control group and busulfan treated group. Busulfan treated grou...
Source: Ultrastructural Pathology - July 17, 2023 Category: Pathology Authors: Reem Ibrahim Abd El-Hay Walaa H E Hamed Nesreen Mostafa Omar Dalia Refat El-Bassouny Salwa A Gawish Source Type: research

50th Anniversary of Ferrari ’s Berlinetta Boxer
When I was a kid, the first Ferrari I ever really noticed was the Berlinetta Boxer. Today, it is celebrating its 50th birthday. The Lamborghini Miura had come out in 1965 to widespread acclaim; the mid-engine, V12 suoer car caused a sensation. Many consider the Miura to be the world’s first…#ferrari #berlinettaboxer #v12 #mercedes #miura #ferrucciolamborghini #enzoferraris #enzo #gtgts #v12lambos
Source: Reuters: Health - July 16, 2023 Category: Consumer Health News Source Type: news

Digital Toy Company Cryptoys Integrating Kid-Friendly AI Chatbot Into NFTs
The AI software, called ChatGuardian, features a chat filter that parents can customize to ensure that their kids have safe, appropriate conversations with their NFT characters. Parents will be able to log into Cryptoys’ Guardian Control Center and prohibit specific keywords and topics at their…#chatguardian #nft #willweinraub #onchainstudio #coindesk #ip #googlehome #weinraub #alfonsomartinez #onchainstudios
Source: Reuters: Health - July 15, 2023 Category: Consumer Health News Source Type: news

Effect of pony morphology and hay feeding methods on back and neck postures
AbstractThe application of hay feeding devices, such as the use of hay nets or slow feeders, can help with the management of weight in ponies; however, there is still a lack of knowledge regarding their effect on equine posture. Therefore, the aim of the study was to assess the effect of different feeding devices on the posture of ponies using morphometric analysis. Two different breed types, Shetland type (SH,n = 5) versus Welsh Cob type (WC,n = 4), were fed the same forage in four different ways: on the ground (G), using a fully filled haynet (HF), using a partially filled haynet (HL) and using a slow-feeder hay...
Source: Journal of Animal Physiology and Animal Nutrition - July 15, 2023 Category: Zoology Authors: Clara Bordin, Federica Raspa, Patricia Harris, Andrea Dorothea Ellis, Angela Roggero, Claudia Palestrini, Domenico Bergero, Emanuela Valle Tags: SPECIAL ISSUE ARTICLE Source Type: research

FDA OKs Chinese Drug Imports; Kid Cancers Down But Still Up; J & J Amps Up Talc Fight
(MedPage Today) -- The FDA agreed to allow additional imports of cancer drugs from China to help relieve current shortages of multiple drugs. (The Hill) HHS has proposed $9 billion in payments to hospitals that were underpaid by the 340B drug...
Source: MedPage Today Hematology/Oncology - July 14, 2023 Category: Hematology Source Type: news

Orientation mapping of YbSn3 single crystals based on Bragg-dip analysis using a delay-line superconducting sensor
Recent progress in high-power pulsed neutron sources has stimulated the development of the Bragg-dip and Bragg-edge analysis methods using a two-dimensional neutron detector with high temporal resolution to resolve the neutron energy by the time-of-flight method. A delay-line current-biased kinetic inductance detector (CB-KID) is a two-dimensional superconducting sensor with a high temporal resolution and multi-hit capability. Here, it is demonstrated that a delay-line CB-KID with a 10B neutron conversion layer can be applied to high-spatial-resolution neutron transmission imaging and spectroscopy up to 100 eV. Dip str...
Source: Journal of Applied Crystallography - July 14, 2023 Category: Physics Authors: Shishido, H. Vu, T.D. Aizawa, K. Kojima, K.M. Koyama, T. Oikawa, K. Harada, M. Oku, T. Soyama, K. Miyajima, S. Hidaka, M. Suzuki, S.Y. Tanaka, M.M. Kawamata, S. Ishida, T. Tags: neutron imaging Bragg dips superconducting detectors current-biased kinetic inductance detectors YbSn3 crystal orientation mapping delay-line sensors single crystals research papers Source Type: research

In Defense of Parasocial Relationships
I’ve been juggling parasocial relationships for most of my life. As a newly online kid in the 1990s, I downloaded programs that helped me make fan art featuring my favorite bands: Dashboard Confessional, Something Corporate, and Blink-182. Now, a couple decades later, I refer to these artists by their first names (Chris, Andrew, Mark) to my friends and family and passionately defend them on internet forums. Thanks to TikTok and Instagram, I can tell you with authority what their kitchens look like, what their dogs are named, and what they put in their morning smoothies. Is it any wonder I feel like I know them? [time...
Source: TIME: Health - July 13, 2023 Category: Consumer Health News Authors: Angela Haupt and Video by Andrew D. Johnson Tags: Uncategorized healthscienceclimate Mental Health Source Type: news

Effects of different forage proportions in fermented total mixed ration on muscle fatty acid profile and rumen microbiota in lambs
ConclusionOverall, oat-based roughage in FTMR could promote a beneficial lipid pattern in the Longissimus lumborum muscles of lambs. These findings provide a potential insight into diet effects on fatty acid profile and the rumen microbiome of lambs, which may help make decisions regarding feeding.
Source: Frontiers in Microbiology - July 13, 2023 Category: Microbiology Source Type: research

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