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Cancers, Vol. 15, Pages 4619: Repurposing Clemastine to Target Glioblastoma Cell Stemness
hristopher J. Pirozzi
Yiping He
Brain tumor-initiating cells (BTICs) and tumor cell plasticity promote glioblastoma (GBM) progression. Here, we demonstrate that clemastine, an over-the-counter drug for treating hay fever and allergy symptoms, effectively attenuated the stemness and suppressed the propagation of primary BTIC cultures bearing PDGFRA amplification. These effects on BTICs were accompanied by altered gene expression profiling indicative of their more differentiated states, resonating with the activity of clemastine in promoting the differentiation of normal oligodendrocyte progenitor cells (OPCs) into mat...
Source: Cancers - September 18, 2023 Category: Cancer & Oncology Authors: Michael A. Sun Rui Yang Heng Liu Wenzhe Wang Xiao Song Bo Hu Nathan Reynolds Kristen Roso Lee H. Chen Paula K. Greer Stephen T. Keir Roger E. McLendon Shi-Yuan Cheng Darell D. Bigner David M. Ashley Christopher J. Pirozzi Yiping He Tags: Article Source Type: research
This angry Dad went viral after blowing $1,200 on Disneyland tickets, blasts company as the ' biggest money printing machine on earth '
If you have a kid who’s dying to go to a Disney theme park, you may want to persuade them otherwise — for your wallet and for your sanity. Mario Zelaya recently posted a TikTok about the 1,100 euros (about $1,200) he spent on tickets for his family’s visit to Disneyland Paris. “I made a huge…#disney #mariozelaya #tiktok #disneylandparis #nonerich #jeffbezos #zelaya #goofy #bruno #encanto
Source: Reuters: Health - September 17, 2023 Category: Consumer Health News Source Type: news
My First MDMA Journey (Solo)
Yesterday I had my first MDMA journey, alone. I had planned to do it about two weeks in advance, knowing it was going to be a big deal for me. It was not what I expected. But I think it was the most remarkably life-shifting experience I’ve ever had. I can tell it changed me profoundly.
The short version is that it was like having my higher self embody me fully for 8-9 hours, letting me feel HIS feelings, hear HIS thoughts, speak with HIS voice, understand HIS perspective, and experience HIS energy. No, it wasn’t LIKE that. It was EXACTLY that.
Here’s the more detailed version:
I got up early that...
Source: Steve Pavlina's Personal Development Blog - September 17, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Lifestyle Source Type: blogs
I ' m sick of people blaming me for my student-loan debt. It ' s not all my fault
Getty Images I'm often blamed for complaining about my student-loan debt. But I was never taught financial literacy, and I built up debt as a kid based on misguided advice. I was trained to believe the more expensive colleges were better. After a three-year pause, my student-loan repayments are…#airbnb #emersoncollege
Source: Reuters: Health - September 16, 2023 Category: Consumer Health News Source Type: news
We have some bad news
MMCrypto: https://www.youtube.com/@MMCryptoTube Davincij15: https://www.youtube.com/@davincij15 Crypto Kid: ...#mmcrypto
Source: Reuters: Health - September 16, 2023 Category: Consumer Health News Source Type: news
Proliferation and migration of ML1 follicular thyroid cancer cells are inhibited by IU1 targeting USP14: role of proteasome and autophagy flux
Front Cell Dev Biol. 2023 Aug 30;11:1234204. doi: 10.3389/fcell.2023.1234204. eCollection 2023.ABSTRACTUSP14 is a deubiquitinating enzyme involved in protein degradation by interacting with the proteasome and removal of poly-ubiquitin chains on target proteins. USP14 can influence cellular processes such as cell survival, DNA repair, ER stress, endocytosis, and the inflammatory response. USP14 further plays a role in tumor growth, and the inhibition of USP14 by compounds such as IU1 may affect cancer cell migration and invasion. Here we have studied the mechanisms for the action of IU1 in ML1 follicular thyroid cancer cell...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Vignesh Srinivasan Muhammad Yasir Asghar Sadia Zafar Kid T örnquist Dan Lindholm Source Type: research
After Years Of Expanding His Range And Working With His Uncles, Darius McGhee Has Reached The NBA
The smaller guard, who is on the doorstep of reaching the NBA, has always adored the game. As a kid, he used to do basketball drills with his uncle, and his family remembers him working on his skills at a young age. “I think I was just one of those kids that always loved it,” McGhee, who played in…#nba #summerleague #indianapacers #mcghee #northcarolina #roxboro #virginia #blueridgeschool #ncaa #campbelluniversity
Source: Reuters: Health - September 14, 2023 Category: Consumer Health News Source Type: news
The Times They Are A-Changing … .Fast
By KIM BELLARD
If you have been following my Twitter – oops, I mean “X” – feed lately, you may have noticed that I’ve been emphasizing The Coming Wave, the new book from Mustafa Suleyman (with Michael Bhaskar). If you have not yet read it, or at least ordered it, I urge you to do so, because, frankly, our lives are not going to be the same, at all. And we’re woefully unprepared.
One thing I especially appreciated is that, although he made his reputation in artificial intelligence, Mr. Suleyman doesn’t only focus on AI. He also discusses synthetic biology, quantum computing, robotics, and new energ...
Source: The Health Care Blog - September 14, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI Kim Bellard quantum computing Smart Pills synthetic biology The Coming Wave Source Type: blogs
How do determinants of health relate to children's quality of life? A cross-sectional study in Izmir, Turkey
This study aims to determine health-related quality of life (QoL) and the related factors from the perspective of social determinants of health among children.BACKGROUND: Childhood is the most intense period of life, and environmental factors surrounding children, as well as individual lifestyle factors, are related to the child's physical and mental well-being. To our knowledge, there is a lack of studies evaluating the relationship between determinants of health and the QoL of healthy children in general.METHODS: This cross-sectional study was executed in the Bayrakli district of Izmir city. Stratified clustered sampling...
Source: Primary Care - September 14, 2023 Category: Primary Care Authors: Hilal Duzel Isil Ergin Raika Durusoy Source Type: research
Want to Impress Your Coworkers? Bake For Them
WHEN I STARTED working in the kitchen, I didn’t have any formal culinary training. I had spent a lot of time as a kid parked in front of the TV watching PBS cooking shows and the Food Network, and working my way through my parents’ cookbooks. In high school and college, I loved cooking for my…#pbs #foodnetwork
Source: Reuters: Health - September 13, 2023 Category: Consumer Health News Source Type: news
Gaming, DEI, and Equal Opportunity
Gaming consultant Bill Pascrell III has a story to tell. “More than a decade ago, I did a panel at ICE on diversity. You don’t ever call a white guy a minority, but I was the only white kid in my kindergarten class – that gives me sensitivity to what minorities go through,” he said. My, how times…#billpascrelliii #ice #asians #hispanics #caesarsentertainment #caesars #boardofdirectors #supremecourt #paspa #mgm
Source: Reuters: Health - September 13, 2023 Category: Consumer Health News Source Type: news
Are real world assets set to take market share?
The blockchain has seen many narratives over the years. Some of these have turned into actual use cases and continued with strength. But there is a new kid on the block, and they go by the name of real world assets (RWAs). In simple terms, RWAs are tangible assets from the physical world that…#tvl #defi #tradfi #ondofinance #maplefinance #access #web2 #nigeria #iliassalvatore #floozxyz
Source: Reuters: Health - September 13, 2023 Category: Consumer Health News Source Type: news
4 Ways to Help Your Child Adapt to Life ’s Rapid Changes
If you’re a parent, you often feel that life today is complicated, overloaded, and moving at warp speed. Technological advances like AI are creating exponential change, the world is getting hotter, and the future is hard to imagine–both for ourselves and our kids. The world is brimming with uncertainty as life races forward. Scientists are calling our era “The Great Acceleration,” and it’s creating unprecedented challenges for us as we raise our children.
As mental health professionals working with families, we meet so many parents who are afraid that their kids aren’t equipped for al...
Source: TIME: Health - September 13, 2023 Category: Consumer Health News Authors: Heather Tedesco, Jennifer Weaver, and Catherine McCarthy Tags: Uncategorized freelance Source Type: news
Detection of fungi in the airways of horses according to the sample site: a methodological study
AbstractFungal detection in equine airways may be performed on either tracheal wash (TW) or bronchoalveolar lavage fluid (BALF) by either cytology or culture. However, method comparisons are sparse. Our objective was to determine the prevalence of fungi in airways of horses according to the sample site and laboratory methodology. Sixty-two adult horses, investigated in the field or referred for respiratory disease, were included. Tracheal wash, and BALF collected separately from both lungs, were collected using a videoendoscope. Fungi were detected in cytologic samples examined by light microscopy, and by fungal culture. H...
Source: Veterinary Research Communications - September 13, 2023 Category: Veterinary Research Source Type: research
