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Total 244 results found since Jan 2013.
Abstract IA27: Understanding more about risk and prognostic factors: Lessons from the Colon Cancer Family Registry
Conclusions: The CCFR has shed light on many environmental factors, genetics and tumor characteristics that are related to both incidence and survival. Information gained from studies using this resource provides insight into the biology of this common cancer and importantly may help target messaging on prevention, inform the development of interventions, or tailor recommendations for CRC survivorship care. The greater scientific community has access to this rich resource.Citation Format: Polly A. Newcomb. Understanding more about risk and prognostic factors: Lessons from the Colon Cancer Family Registry. [abstract]. In: P...
Source: Cancer Research - January 30, 2017 Category: Cancer & Oncology Authors: Polly A. Newcomb Tags: Outcomes, Survivorship, and Health Disparities Source Type: research
Muir-Torre syndrome caused by exonic deletion of MLH1 due to homologous recombination
ConclusionsFor the genetic analysis of MTS, the possibility of rare copy number variations ofMLH1, as well asMSH2 variations, should be considered. RNA-based screening using puromycin is recommended in order to identify such variations. It remains unclear why only the proband among the pedigree had skin malignancies, however, the skin carcinogenesis might have been related to occupational radiation exposure.
Source: European Journal of Dermatology - December 31, 2016 Category: Dermatology Source Type: research
The Interactions Between Gut Microbiota and Lynch Syndrome
To investigate the interactions between gut microbiota and Lynch syndrome (or hereditary nonpolyposis colorectal cancer, HNPCC).
Source: Clinical Gastroenterology and Hepatology - December 14, 2016 Category: Gastroenterology Authors: Xiao-juan Lu, Qian Kang, Peng Jin, Jian-qiu Sheng Source Type: research
Mismatch repair protein expression status in Egyptian colorectal carcinoma: a single-centre study
Conclusion: HNPCC is not uncommon in Egypt. Immunohistochemistry can detect MMR-deficient CRCs and can specify the defective gene. Thus, routine testing of all newly diagnosed CRCs for MMR protein expression is recommended to identify suspected cases of HNPCC and accordingly direct their future management.
Source: Egyptian Journal of Pathology - December 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Cytotoxic and targeted therapy for hereditary cancers
AbstractThere is a number of drugs demonstrating specific activity towards hereditary cancers. For example, tumors in BRCA1/2 mutation carriers usually arise via somatic inactivation of the remaining BRCA allele, which makes them particularly sensitive to platinum-based drugs, PARP inhibitors (PARPi), mitomycin C, liposomal doxorubicin, etc. There are several molecular assays for BRCA-ness, which permit to reveal BRCA-like phenocopies among sporadic tumors and thus extend clinical indications for the use of BRCA-specific therapies. Retrospective data on high-dose chemotherapy deserve c onsideration given some unexpected ...
Source: Hereditary Cancer in Clinical Practice - August 22, 2016 Category: Cancer & Oncology Source Type: research
Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC)
The purpose of this study was to identify novel colorectal cancer (CRC)-causing alleles in unexplained familial CRC cases. In order to do so, coding regions in five candidate genes (MGMT, AXIN2, CTNNB1, TGFBR1 and TGFBR2) were sequenced in 11 unrelated microsatellite-stable hereditary non-polyposis CRC (MSS HNPCC) cases. Selected genetic variants were genotyped in a discovery set of 27 MSS HNPCC cases and 85 controls. One genetic variant, rs67687202, in TGFBR1 emerged as significant (P = 0.002), and it was genotyped in a replication set of 87 additional MSS HNPCC-like cases and 338 controls where it was also significantly ...
Source: Carcinogenesis - July 29, 2016 Category: Cancer & Oncology Authors: Xicola, R. M., Bontu, S., Doyle, B. J., Rawson, J., Garre, P., Lee, E., de la Hoya, M., Bessa, X., Clofent, J., Bujanda, L., Balaguer, F., Castellvi-Bel, S., Alenda, C., Jover, R., Ruiz-Ponte, C., Syngal, S., Andreu, M., Carracedo, A., Castells, A., Newco Tags: Original Manuscript Source Type: research
First description of mutational analysis of MLH1, MSH2 and MSH6 in Algerian families with suspected Lynch syndrome
In this study, we confirmed that MSH2 , MLH1, and MSH6 contribute to CRC susceptibility. This work represents the implementation of a diagnostic algorithm for the identification of Lynch syndrome patients in Algerian families.
Source: Familial Cancer - July 27, 2016 Category: Cancer & Oncology Source Type: research
HMSH2 and HMSH6 gene expression profiles in colorectal adenocarcinoma in patients up to 50 years of age.
Abstract
Lynch syndrome, previously called hereditary non-polyposis colorectal cancer (HNPCC), is a major mortality threat. It is an autosomal dominant disease which is caused by a germline mutation in the DNA mismatch repair (MMR), especially in patients aged up to 50 years. Such mutation more frequently occurs in the hMSH2 gene (38-40%) and less frequently in the hMSH6 gene (14-16%). These mutations, when associated with the patient's lifestyle, may reveal a considerable variability in the disease manifestations, such as the degrees of penetrance and clinical aggressiveness. The aim of this study is to analyze t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 22, 2016 Category: Drugs & Pharmacology Authors: Germini D, Gehrke F, Lira D, Alves B, Azzalis L, Perez M, Fonseca F, Waisberg J Tags: Biomed Pharmacother Source Type: research
Upper tract urothelial carcinoma: epidemiology, high risk populations, and detection.
Authors: Redrow GP, Matin SF
Abstract
Upper tract urothelial carcinoma (UTUC) is a rare but highly morbid genitourinary malignancy. In 2014 approximately 15000 new cases were diagnosed in the United States. It accounts for approximately 5-10% of all urothelial cell carcinomas, and 10% of renal tumors. Recent research has increased understanding of the epidemiology of this disease, including several high-risk populations. Environmental exposure to tobacco as well as aristolochic acid, and other carcinogens significantly increase the development of UTUC. Additionally, the genetic condition of hereditary nonpolyposis ...
Source: Minerva Urologica e Nefrologica - March 25, 2016 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Hereditary non ‐polyposis colorectal cancer/Lynch syndrome in three dimensions
ConclusionHereditary colorectal cancer can be confusing. Sorting families in three dimensions can clarify the confusion and may direct further testing and, ultimately, surveillance.
Source: ANZ Journal of Surgery - March 16, 2016 Category: Surgery Authors: Sara E. Kravochuck, James M. Church Tags: COLORECTAL SURGERY Source Type: research
Hereditary non‐polyposis colorectal cancer/Lynch syndrome in three dimensions
ConclusionHereditary colorectal cancer can be confusing. Sorting families in three dimensions can clarify the confusion and may direct further testing and, ultimately, surveillance.
Source: ANZ Journal of Surgery - March 16, 2016 Category: Surgery Authors: Sara E. Kravochuck, James M. Church Tags: Original Article Source Type: research
Six Ways to Lower Your Risk for Colon Cancer
By Stacy Simon Colon cancer is one of the more common cancers in the US. About 1 in 20 Americans will develop colon cancer at some point during their lifetime. But there are things you can do to help lower your colon cancer risk. Here are 6 ways to help protect your colon health. Get screened for colon cancer. Screenings are tests that look for cancer before signs and symptoms develop. Colon screenings can often find growths called polyps that can be removed before they turn into cancer. These tests also can find colon cancer earlier, when treatments are more likely to be successful. The American Cancer Society recommend...
Source: American Cancer Society :: News and Features - March 7, 2016 Category: Cancer & Oncology Tags: Colon/Rectum Cancer Source Type: news
Hereditary non-BRCA gynaecological tumors.
Authors: Vellone VG, Paudice M, Varesco L
Abstract
Early diagnosis and proper management of gynecologic malignancies represent a challenge in modern oncology. A growing interest has arisen around the gynecological manifestations of hereditary cancer syndromes. In particular, the discovery of the BRCA1 and BRCA2 genes in ovarian cancer and the mismatch repair genes (MMR) in endometrial carcinoma has revolutionized our approach to the diagnosis and screening of women for ovarian and uterine cancers. The clinical, genetic and pathological features of hereditary cancer syndromes with gynecological manifestations are re...
Source: Minerva Ginecologica - March 2, 2016 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Signs and Symptoms of Colon Cancer
By Stacy Simon Many of the symptoms of colon cancer can also be caused by something that isn’t cancer, such as infection, hemorrhoids, irritable bowel syndrome, or inflammatory bowel disease. In most cases, people who have these symptoms do not have cancer. Still, if you have any of these problems, it is a sign that you should go to the doctor so the cause can be found and treated, if needed:A change in bowel habits, such as diarrhea, constipation, or narrowing of the stool, that lasts for more than a few daysA feeling that you need to have a bowel movement that is not relieved by doing soRectal bleedingDark stools, ...
Source: American Cancer Society :: News and Features - February 29, 2016 Category: Cancer & Oncology Tags: Colon/Rectum Cancer Prevention/Early Detection Source Type: news
Risk-reduction surgery in pediatric surgical oncology: A perspective
A small percentage of pediatric solid cancers arise as a result of clearly identified inherited predisposition syndromes and nongenetic lesions. Evidence supports preemptive surgery for children with genetic [multiple endocrine neoplasia type 2 (MEN2), familial adenomatous polyposis syndrome (FAP), hereditary nonpolyposis colorectal cancer (HNPCC), and hereditary diffuse gastric cancer (HDGC) and nongenetic [thyroglossal duct cysts (TGDC), congenital pulmonary airway malformations (CPAM), alimentary tract duplication cysts (ATDC), and congenital choledochal cysts (CCC)] developmental anomalies.
Source: Journal of Pediatric Surgery - February 18, 2016 Category: Surgery Authors: John A. Sandoval, Israel Fernandez-Pineda, Alpin D. Malkan Tags: Review Article Source Type: research
