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Total 244 results found since Jan 2013.
Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature
It is a known fact that Lynch syndrome (LS) and Ulcerative colitis (UC) are individually associated with increased risk of colorectal cancer. While there is no conclusive evidence to demonstrate a cumulative risk when these two conditions coexist, available data suggest early onset and synchronous cancers are synonymous to this group. We have reported an unusual case of multiple synchronous colorectal cancers in a young man with ulcerative colitis and Lynch syndrome also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC) gene mutation. We propose that conducting a detailed genetic mutation profile in LS patients ma...
Source: Frontiers in Oncology - December 22, 2022 Category: Cancer & Oncology Source Type: research
BAT25, ACVR2, and TGFBR2 Mononucleotide STR Markers: A Triplex Panel for Microsatellite Instability Testing in Colorectal Tumors
CONCLUSIONS: A high sensitivity and specificity for the novel triplex panel in MSI-testing were estimated among Iranian patients. More studies are recommended to confirm this panel as a diagnostic kit for MSI testing.PMID:36393819 | PMC:PMC9651191 | DOI:10.4103/abr.abr_205_21
Source: Biomed Res - November 17, 2022 Category: Research Authors: Paniz Miar Mohammad Amin Tabatabaiefar Zeinab Abdollahi Mahnaz Noruzi Mohammad Kazemi Azar Naimi Mohammad Hasan Emami Shahrokh Izadi Mehrdad Zeinalian Source Type: research
IJERPH, Vol. 19, Pages 14517: Desire for Children and Distress in Women with Hereditary Cancer Syndromes
This study aimed to gain insights into the relationship between the desire for children and the distress of female carriers. Women (N = 255) with different hereditary cancer syndromes were assessed from November 2019 to July 2021 at genetic counseling centers, the centers of the German HBOC-Consortium and the centers of the German HNPCC-Consortium regarding their distress levels with the NCCN Distress Thermometer (DT). The desire for children was measured by self-developed questions. Levels of distress and desire for children were evaluated descriptively. Factors influencing the desire for children and distress were calcul...
Source: International Journal of Environmental Research and Public Health - November 4, 2022 Category: Environmental Health Authors: Anna Maria Kastner Hatice K übra Kocak Josefine Fischer-Jacobs Andrea Hahne Tanja Zimmermann Tags: Article Source Type: research
Lynch syndrome: An unusal case of familial cancer unearthed
Indian J Pathol Microbiol. 2022 Apr-Jun;65(2):465-467. doi: 10.4103/IJPM.IJPM_809_19.ABSTRACTLynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer. There is an increased predisposition to cancers in the endometrium, colon, stomach, ovary, uterus, skin, kidney, and brain in patients of Lynch syndrome. We are reporting a 48-year-old male who presented with a pea-sized growth in his left arm which was found to be sebaceoma on histopathology. On further detailed history, examination, and genetic study, it was proved ...
Source: Indian Journal of Pathology and Microbiology - April 18, 2022 Category: Pathology Authors: Subhra Dhar Ashraf U Mannan J Jaya Singh Sandipan Dhar Swetalina Pradhan Source Type: research
