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Total 244 results found since Jan 2013.
Constitutional MLH1 Methylation Is a Major Contributor to Mismatch Repair-Deficient, MLH1-Methylated Colorectal Cancer in Patients Aged 55 Years and Younger
CONCLUSIONS: Although rare overall, a significant proportion of younger patients with MLH1-methylated CRC had underlying constitutional MLH1 methylation. Routine testing for this high-risk mechanism is warranted in patients aged ≤55 years for a timely and accurate molecular diagnosis that will significantly alter their clinical management while minimizing additional testing.PMID:37433431 | DOI:10.6004/jnccn.2023.7020
Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 11, 2023 Category: Cancer & Oncology Authors: Megan P Hitchins Estela D ámaso Rocio Alvarez Lisa Zhou Yajing Hu Marcio A Diniz Marta Pineda Gabriel Capella Rachel Pearlman Heather Hampel Source Type: research
Lung Cancer in Patients With Lynch Syndrome: Association or Coincidence?
Clin Lung Cancer. 2023 May 31:S1525-7304(23)00109-2. doi: 10.1016/j.cllc.2023.05.007. Online ahead of print.ABSTRACTLynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC) occurs due to microsatellite instability (MSI) caused by mutations in one of the mismatch repair genes leading to deficient mismatch repair proteins (dMMR). Although lung cancer is very common there is no established association between LS and lung cancer. In this manuscript we describe a case of lung cancer in a LS patient and then summarize available literature on this topic. Sixty seven y/o female patient with history of s...
Source: Clinical Colorectal Cancer - June 19, 2023 Category: Cancer & Oncology Authors: Umair Majeed Karan Seegobin Jason Lewis Shenduo Li Yujie Zhao Yanyan Lou Rami Manochakian Source Type: research
Surgical strategies for hereditary colorectal cancer
Chirurgie (Heidelb). 2023 Mar 1. doi: 10.1007/s00104-023-01823-y. Online ahead of print.ABSTRACTHereditary colorectal cancer (hCRC) represents a major diagnostic and therapeutic challenge. In addition to the usual diagnostic methods, the family history, histological confirmation and mutation analysis play an important role in identifying the type of hereditary CRC. The diagnosis and classification of hCRC are carried out based on the anamnesis, clinical presentation and histology and the further treatment is determined depending on the underlying type of hCRC. For familial adenomatous polyposis (FAP) coloproctomucosectomy ...
Source: Cancer Control - March 1, 2023 Category: Cancer & Oncology Authors: M Kelm A Wiegering C-T Germer S Flemming Source Type: research
Reduced expression of alanyl aminopeptidase is a robust biomarker of non ‐familial adenomatous polyposis and non‐hereditary nonpolyposis colorectal cancer syndrome early‐onset colorectal cancer
ConclusionThe reduced expression of ANPEP was identified as a novel biomarker of non-FAP and non-HNPCC EOCRC.
Source: Cancer Medicine - February 7, 2023 Category: Cancer & Oncology Authors: Ye Jin Ha,
Yun Jae Shin,
Ka Hee Tak,
Jong Lyul Park,
Jeong Hwan Kim,
Jong Lyul Lee,
Yong Sik Yoon,
Chan Wook Kim,
Seon Young Kim,
Jin Cheon Kim Tags: RESEARCH ARTICLE Source Type: research
Genes, Vol. 14, Pages 341: Identification of Germline Variants in Patients with Hereditary Cancer Syndromes in Northeast Mexico
ndro Zayas-Villanueva
Juan Francisco González-Guerrero
Adelina Alcorta-Garza
Oscar Vidal-Gutiérrez
Carlos Horacio Burciaga-Flores
Hereditary cancer syndromes (HCS) are genetic diseases with an increased risk of developing cancer. This research describes the implementation of a cancer prevention model, genetic counseling, and germline variants testing in an oncologic center in Mexico. A total of 315 patients received genetic counseling, genetic testing was offered, and 205 individuals were tested for HCS. In 6 years, 131 (63.90%) probands and 74 (36.09%) relatives were tested. Among the probands, we found that...
Source: Genes - January 28, 2023 Category: Genetics & Stem Cells Authors: Diana Cristina P érez-Ibave Mar ía Lourdes Garza-Rodríguez Mar ía Fernanda Noriega-Iriondo Sonia Mar ía Flores-Moreno Manuel Ismael Gonz ález-Geroniz Absalon Espinoza-Velazco Ana Lilia Castruita- Ávila Fernando Alcorta-N úñez Omar Alejandro Zayas Tags: Article Source Type: research
Cancers, Vol. 15, Pages 353: Evaluation of Microsatellite Instability Molecular Analysis versus Immuno-Histochemical Interpretation in Malignant Neoplasms with Different Localizations
John Souglakos
MMR gene germline mutations are considered a major genetic disorder in patients with hereditary nonpolyposis colon cancer (HNPCC) or Lynch syndrome; A total of 15% of sporadic colon carcinomas are MSI-High. MSI has also been observed in other cancers, such as endometrial, gastric, and ovarian cancer. The aim of the current study was to correlate and outline the optimal method between the molecular testing of the instability of microsatellite DNA regions (MSI status) and the loss of protein expression by immunehistochemistry (MMR). A total of 242 paraffin-embedded tissues from gastrointestinal, gynecol...
Source: Cancers - January 5, 2023 Category: Cancer & Oncology Authors: Maria Sfakianaki Maria Tzardi Konstantina Tsantaki Chara Koutoulaki Ippokratis Messaritakis Galateia Datseri Eleni Moustou Dimitrios Mavroudis John Souglakos Tags: Article Source Type: research
