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Total 244 results found since Jan 2013.

Isolation and Characterization of Chemo-Resistant Stem Cells from a Mouse Model of Hereditary Non-Polyposis Colon Cancer
CONCLUSION: In the present study, a stem cell model for HNPCC was validated and offered a novel experimental approach to test stem cell-targeted alternatives to drug-resistant therapy.PMID:34234468 | PMC:PMC8254583 | DOI:10.2147/SCCAA.S312929
Source: Stem Cells and Cloning: Advances and Applications - July 8, 2021 Category: Stem Cells Authors: Nitin Telang Source Type: research

Deciding the operation type according to mismatch repair status among hereditary nonpolyposis colorectal cancer patients: should a tailored approach be applied, or does one size fit all?
CONCLUSIONS: Significantly better overall survival and higher rate of metachronous CRC exist in dMMR subgroup of HNPCC patients comparing with pMMR subgroup. Extended colectomy significantly improved DFS and was thus recommended for dMMR subgroup but not pMMR subgroup of HNPCC patients.PMID:34187536 | PMC:PMC8243908 | DOI:10.1186/s13053-021-00186-x
Source: Clinical Colorectal Cancer - June 30, 2021 Category: Cancer & Oncology Authors: Chun-Kai Liao Yueh-Chen Lin Yu-Jen Hsu Yih-Jong Chern Jeng-Fu You Jy-Ming Chiang Source Type: research

Copy Number Variants Captured by the Array Comparative Genomic Hybridization in a Cohort of Patients Affected with Hereditary Colorectal Cancer in Sri Lanka: The First CNV Analysis Study of the Hereditary Colorectal Cancer in the Sri Lankan Population
CONCLUSION: This study shows that CNVs are likely contributors to the colorectal cancer predisposition in a small but significant proportion of patients affected with hereditary colorectal cancer in this cohort. Further studies have to perform to get a better understanding on the contribution of CNVs to the cancer predisposition in this cohort of patients in the Sri Lankan population.PMID:34181357 | DOI:10.31557/APJCP.2021.22.6.1957
Source: Asian Pacific Journal of Cancer Prevention - June 28, 2021 Category: Cancer & Oncology Authors: Prabhavi Wijesiriwardhana Kalum Wettasinghe Vajira H W Dissanayeke Source Type: research