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Total 244 results found since Jan 2013.

Detection of Microsatellite Instability in Colorectal Cancer Patients With a Plasma-Based Real-Time PCR Analysis
In this study, we evaluated the results of a newly developed plasma-based real-time PCR kit for the detection of MSI in CRC patients. We assessed a peptide nucleotide acid (PNA) probe-mediated real-time PCR test (U-TOP MSI Detection Kit Plus) that determines MSI status by using amplicon melting analysis of five markers (NR21, NR24, NR27, BAT25, and BAT26) from plasma. Eighty-four CRC patients (46 dMMR and 38 pMMR) with colorectal cancer were analyzed. The concordance rate of MSI status assessment between the plasma kit and IHC was 63.0% in dMMR patients (29/46), but in the pMMR evaluation, a 100% (38/38) concordance rate w...
Source: Frontiers in Pharmacology - December 8, 2021 Category: Drugs & Pharmacology Source Type: research

Lynch syndrome-associated epithelial ovarian cancer and its immunological profile
CONCLUSION: MMR-d, MSI, and TILs are also seen in Lynch syndrome-associated ovarian cancers making these potential candidates for checkpoint-based immunotherapy. The clinical impact from immune evasion through loss of B2M needs to be investigated further in larger cohorts.PMID:34275654 | DOI:10.1016/j.ygyno.2021.07.001
Source: Gynecologic Oncology - July 19, 2021 Category: Cancer & Oncology Authors: Maria Rasmussen Kevin Lim Eva Rambech Mads Hald Andersen Inge Marie Svane Ove Andersen Lars Henrik Jensen Mef Nilbert Christina Therkildsen Source Type: research

Co-Occurrence of Familial Non-Medullary Thyroid Cancer (FNMTC) and Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Associated Tumors —A Cohort Study
Familial non-medullary thyroid cancer (FNMTC) is a form of endocrine malignancy exhibiting an autosomal dominant mode of inheritance with largely unknown germline molecular mechanism. Hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is another hereditary autosomal dominant cancer syndrome which, if proven to be caused by germline mutations in mismatch repair genes (MMR)—MLHL, MSH2, MSH6, PMS2, and EPCAM—is called Lynch syndrome (LS). LS results in hereditary predisposition to a number of cancers, especially colorectal and endometrial cancers. Tumors in LS are characterized by microsatellite instability (M...
Source: Frontiers in Endocrinology - July 13, 2021 Category: Endocrinology Source Type: research

Isolation and Characterization of Chemo-Resistant Stem Cells from a Mouse Model of Hereditary Non-Polyposis Colon Cancer
CONCLUSION: In the present study, a stem cell model for HNPCC was validated and offered a novel experimental approach to test stem cell-targeted alternatives to drug-resistant therapy.PMID:34234468 | PMC:PMC8254583 | DOI:10.2147/SCCAA.S312929
Source: Stem Cells and Cloning: Advances and Applications - July 8, 2021 Category: Stem Cells Authors: Nitin Telang Source Type: research