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Latest Legal Settlements Suggest Hazards of Making Pharmaceutical Regulation More Lenient, as is Apparently Favored by New FDA Leader
DiscussionAll the cases discussed above were of behavior that could have harmed patients.  Many of the companies involved had records of previous ethical misadventures.  While a few cases resulted in corporate guilty pleas (to misdemeanors), none resulted in monetary penalties that would have much impact on the companies ' finances, and none resulted in any negative consequences for people who enabled, authorized, directed or implemented the bad behavior.These, just the latest in the march oflegal settlements by large health care organizations, again demonstrate how often and how seriously pharmaceutical companie...
Source: Health Care Renewal - October 1, 2017 Category: Health Management Tags: adulterated drugs Celgene crime deception FDA impunity legal settlements market fundamentalism Novo Nordisk revolving doors thalidomide Source Type: blogs

Alcoholic Beverages Cause Cancer; Industry Groups Advocate " Responsible " Drinking
Clear patterns have emerged relating alcoholic beverage consumption to the development of head and neck cancer, esophageal cancer, liver cancer, breast cancer, and colorectal cancer (see:Alcohol and Cancer Risk). Hence, when countries experience high consumption of alcoholic beverages, public health officials worry that their populations may experience a surge in the incidence of such lesions in the future. A recent article discussed this possibility in Europe, particularly GI cancers (see:Love Affair With Alcohol Is Driving GI Cancers). Below is an excerpt from the article:Europe could be headed for sharp increases in rat...
Source: Lab Soft News - September 13, 2017 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Medical Consumerism Medical Education Medical Ethics Medical Research Preventive Medicine Source Type: blogs

Quantum Dots Light Up Tumors Brighter Than Ever Before
Scientists at the Sanford Burnham Prebys Medical Discovery Institute (SBP) in San Diego, California have devised a way to optically image tumors with unprecedented clarity using quantum dots. These nano structures are tiny particles, only a few nanom...
Source: Medgadget - September 7, 2017 Category: Medical Devices Authors: Editors Tags: Genetics Nanomedicine Oncology Source Type: blogs

Bacteria Promote Cancer by Enhancing Stem Cell Replication and Turnover
Bacterial infection has been linked to cancer risk in some cases, and here researchers propose that this is because the bacterial species can cause some stem cell populations to replicate more frequently. Greater cell activity in this fashion over time raises the risk of a cancerous mutation occurring. The authors of the study examine only the one case in which a bacteria-cancer association is well studied, but we might speculate on similar situations elsewhere in the body. While it has long been recognized that certain viruses can cause cancer by inserting oncogenes into the host cell DNA, the fact that some bact...
Source: Fight Aging! - August 18, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

MKSAP: 54-year-old man with dysphagia
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 54-year-old man is evaluated for a 4-month history of intermittent, nonprogressive solid-food dysphagia. He has a long-standing history of heartburn that has been well controlled with once-daily proton-pump inhibitor (PPI) therapy for the past 5 years. Results of a screening colonoscopy 4 years ago were normal. There is no family history of colorectal cancer. Physical examination findings are unremarkable. Upper endoscopy reveals a 3-cm hiatal hernia, an esophageal (Schatzki) ring, and approximately six polyps...
Source: Kevin, M.D. - Medical Weblog - August 12, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions GI Medications Source Type: blogs

On Seeking Counseling Before You Need To
Many clients I see here in private practice in the Midwestern area of Illinois are often very stressed. They come in appearing very calm and as soon as I get to the point on my questionnaire about what brings them their they tell me, often with tears and a sense of shame about how long they have been struggling due to their busy lives, lack of self-care and fears of the judgement might have about them. We talk about the stressors they have been having throughout their lives and although they often say none at first, the more we talk the more profoundly amazed I am that they are doing so well holding all their emotions in f...
Source: World of Psychology - August 9, 2017 Category: Psychiatry & Psychology Authors: Jessica Wright, LCSW Tags: Personal Professional Psychology Psychotherapy Self-Help Stigma Stress Treatment anxiety Entering therapy overwhelm Self Care self-compassion stress reduction support Worry Source Type: blogs

Going After Your Past – The Big National Geographic Ancestry Test Review
Have you ever wondered to which people your ancestors belonged thousands of years ago? Or how your ancestors ended up living in the region where you were born? Did you know that your genes can reveal this information? The National Geographic Ancestry Test promises to take you on a journey into your faraway past and to be part of the Genographic Project aiming to uncover one of the greatest stories of humanity – our origins. I was excited to see what my genes hide so I ordered a test with full of curiosity. Here are my results. Where do we come from? Have you ever wondered where would you find your ancestors if you ha...
Source: The Medical Futurist - July 12, 2017 Category: Information Technology Authors: nora Tags: Genomics ancestry clinicla genetics DNA future gc3 genes Innovation national geographic personal genomics personalized genetics Source Type: blogs

Progress in Engineering Digestive System Tissue Structures
Researchers here report on progress in engineering a few parts of the digestive system. The intestine and sphincter work here goes together with advances in the production of small sections of functional stomach tissue reported earlier this year. The field is doing well, considering that the challenge of generating the blood vessel networks necessary to support larger tissue masses has not yet been resolved. Researchers are finding a fair number of areas where they can proceed to potentially produce useful therapeutic outcomes even absent that capability. Researchers have reached important milestones in their ques...
Source: Fight Aging! - July 6, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The Contribution of Decreasing Cancer Mortality to Gains in Life Expectancy
This study provides an assessment of the impact of improvements in cancer prevention and cancer therapies over the past few decades, based on observed changes in life expectancy. In the opinion of the authors, better prevention is the more important contribution to these results - which doesn't say much for the current high level strategy in cancer research aimed at production of better therapies, given the vast sums devoted to that industry. Because of its focus on cancer, an unusual life expectancy construct is used in this study, considering only ages 40 to 84; cancer has a very low incidence at younger ages, and the ri...
Source: Fight Aging! - June 29, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Doctors should fight fake health news at the checkout aisle
I see them every time I wait in the inescapably long lines at the grocery store. They’re offering me so much. Fat-melting foods that “work like gastric bypass.” Sleep masks that prevent breast cancer. One day diets. And, of course, the perennial “medical miracles.” All these revelations can be mine with a simple magazine purchase. It’s easy to dismiss the medical advice being propagated through the supermarket checkout aisle. Who would take health advice from a magazine sitting next to a box of Snickers and the National Enquirer? This visceral elitism, however, is causing doctors and scientists to miss out on a...
Source: Kevin, M.D. - Medical Weblog - June 24, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/benjamin-mazer" rel="tag" > Benjamin Mazer, MD, MBA < /a > Tags: Physician Primary care Source Type: blogs

Fight Aging! Newsletter, June 19th 2017
This study is the first to show that downregulation of PAPP-A expression in adult mice can significantly extend life span. Importantly, this beneficial longevity phenotype is distinct from the dwarfism of long-lived PAPP-A KO, Ames dwarf, Snell dwarf and growth hormone receptor (GHR) KO mice with germ-line mutations. Thus, downregulation of PAPP-A expression joins other treatment regimens, such as resveratrol, rapamycin and dietary restriction, which can extend life span when started in mice as adults. In a recent study, inducible knockdown of the GHR in young adult female mice increased maximal, but not median, lif...
Source: Fight Aging! - June 18, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

From “do no harm” to “reduce harm.” It’s time to change the paradigm
The concept of “First, do no harm,” which is embedded in the oath that kicks off the careers of most new doctors in America, has become something of a surrogate for the practice of medicine. But it’s something of a false promise. Doctors routinely cause their patients harm. The oath we should be taking is, “Help others with as little harm as possible.” We live in a world of harm — from car accidents to recreational drugs, sexually transmitted diseases, cancer, unhealthy diets, and lack of exercise. The list goes on. In treating the outcomes of these hazards, the goal as a physician should be to reduce harm. Ta...
Source: Kevin, M.D. - Medical Weblog - June 10, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/amy-ho" rel="tag" > Amy Ho, MD < /a > Tags: Physician Primary care Source Type: blogs

What to do when dementia patients cannot eat
I'm so distraught over my father. He has a Peg tube in, and hasn't had any solid food for over 2 months.Our reader Denise wrote: I'm so distraught over my father. Has a Peg tube andhasn't had any solid food for over 2 months.He asks me all the time for food. Seeing him suffer is too much. If I give him food and then he'll aspirate and he is DNR.I feel like by giving him food i will be contributing to his death sooner. Oh Lord ...so painful.Article -16 Ways to Get a Dementia Patient to Eat More FoodSubscribe to the Alzheimer's Reading RoomEmail:By Dr. Rita A. JablonskiAlzheimer's Reading RoomTo the reader, I would reco...
Source: Alzheimer's Reading Room, The - June 4, 2017 Category: Neurology Tags: alzheimers alzheimers care can't eat care of dementia patients dementia care feeding health lifestyle Source Type: blogs

Doctors Should Also Be Fighting “ Fake News ”
BY BENJAMIN MAZER, MD I see them every time I wait in the inescapably long lines at grocery store. They’re offering me so much. Fat-melting foods that “work like gastric bypass.” Sleep masks that prevent breast cancer. One day diets. And, of course, the perennial “medical miracles.” All these revelations can be mine with a simple magazine purchase. It’s easy to dismiss the medical advice being propagated through the supermarket checkout aisle. Who would take health advice from a magazine sitting next to a box of Snickers and the National Enquirer? This visceral elitism, however, is causing doctors and scientis...
Source: The Health Care Blog - June 1, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Andrew Weil Benjamin Mazer Fake News Mehmet Oz Quackery Source Type: blogs

Fight Aging! Newsletter, May 29th 2017
In this study, we utilized an imaging-based assay to monitor the ability of disease-associated amyloid assemblies to rupture intracellular vesicles following endocytosis. We observe that the ability to induce vesicle rupture is a common feature of α-synuclein (α-syn) assemblies, as assemblies derived from wild type (WT) or familial disease-associated mutant α-syn all exhibited the ability to induce vesicle rupture. Similarly, different conformational strains of WT α-syn assemblies, but not monomeric or oligomeric forms, efficiently induced vesicle rupture following endocytosis. The ability to induce vesicle rupt...
Source: Fight Aging! - May 28, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs