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Fight Aging! Newsletter, March 12th 2018
This study identifies the missing link between Lewy bodies and the type of damage that's been observed in neurons affected by Parkinson's. Parkinson's is a disorder of the mitochondria, and we discovered how Lewy bodies are releasing a partial break-down product that has a high tropism for the mitochondria and destroys their ability to produce energy." Lewy bodies were described a century ago, but it was not until 1997 that scientists discovered they were made of clumps of a misfolded protein called α-synuclein. When it's not misfolded, α-synuclein is believed to carry out functions related to the transmission of...
Source: Fight Aging! - March 11, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

MedCline Reflux Relief System: A Medgadget Product Review
Conclusion: Overall, Amenity Health has created a very high quality product in their MedCline Reflux Relief System. It effectively prevents reflux and is, in my opinion, more comfortable than the more traditional wedges on the market. However, higher...
Source: Medgadget - March 7, 2018 Category: Medical Devices Authors: Kenan Raddawi Tags: Exclusive GI Medicine Source Type: blogs

Hidden Scars from Breast Cancer
Yes there are lots of hidden scars in breast cancer. I have discussed the emotional side a lot - which boils down to PTSD for some. But there is also the physical side. Every time you look at your body and see your cancer scars, you are reminded of  your cancer misadventure. Its only a scar that will fade over time but its still there.Back in 1984, I found my first breast lump. Due to the limitations of surgery at the time, I had to have an excisional biopsy. And because of my medical history (three years after thyroid cancer) they had to be sure. (And if you are trying to calculate my age, I am still only 37). So I h...
Source: Caroline's Breast Cancer Blog - March 6, 2018 Category: Cancer & Oncology Tags: breast cancer treatment lumpectomy progress scars surgery Source Type: blogs

How to Plan and Carry Out a Simple Self-Experiment, a Single Person Trial of Senolytic Peptide FOXO4-DRI
The objective is to wind up with the right amount of FOXO4-DRI dissolved in phosphate buffered saline in a sealed vial, ready to be used with the injection system, and with as little contamination as possible from the environment. Depending on the size of the vial, it might contain doses for multiple injections - in fact it is much easier to set things up this way. FOXO4-DRI dissolves very readily in saline, so placing a single human dose into 0.5ml or 1ml is quite feasible. A 3ml vial can hold three doses for the treatment without issue. One approach is to measure out FOXO4-DRI by weight using a suitable microscale...
Source: Fight Aging! - March 5, 2018 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs

Paligenosis as a Potential Source of Methods to Target Many Types of Cancer with One Type of Therapy
The future of the treatment of cancer will be, must be, dominated by classes of therapy that can be easily and cost-effective applied to many different types of cancer. Such therapies can only exist as a result of targeting mechanisms that are shared by many or all types of cancer. It must also be challenging or impossible for cancerous cells to do without these mechanisms. The biggest issue in cancer research over the past few decades, in my opinion, is the specificity of therapies, the amount of time and resources poured into efforts to produce treatments that can only work on one type or a few types of cancer, and that ...
Source: Fight Aging! - February 27, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Andrographolide and bone destruction
This study shows that andrographolide inhibits the development of osteoclasts ( = the cells that chew away at our bones, which is fine in a healthy situation, not fine in cancer where everything goes nutso), while increasing the presence of osteoblasts (bone builders). The researchers say that the current therapies used to treat osteolytic diseases have many unwanted side effects. And they’re not just referring to bisphosphonates (which can cause osteonecrosis of the jaw) but also to new treatments such as the monoclonal antibody denosumab, Denosumab can cause low calcium levels, weakness, constipation, back/arm/leg pa...
Source: Margaret's Corner - February 21, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs

New Treatment for Breast Cancer Could Help Some Women Avoid Surgery
Most women diagnosed with early stage breast cancer typically have surgery to remove the tumor, followed by three to six weeks of radiation. But there’s an exciting new development in breast cancer treatment – a first-of-its kind radiation therapy system for early stage cancers that may cut the number of treatments to only a few days. And, one day, the inventors say, it might even eliminate the need for surgery altogether for some patients. It’s called the GammaPod, invented by scientists at the University of Maryland School of Medicine. The U.S. Food and Drug Administration (FDA) recently cleared the way for the Gam...
Source: Life in a Medical Center - February 20, 2018 Category: Universities & Medical Training Authors: UMMC Admin Tags: Cancer breast cancer cancer treatment Cedric X. Yu Elizabeth Nichols GammaPod UMMC Source Type: blogs

The miscalculated fear of an opioid crisis in Haiti
Opioids are an essential class of drugs used in pain management. In recent years, complex mechanisms pertaining to their abusive use have prompted a deadly crisis which is unfolding in the United States. The U.S. Centers for Disease Control and Prevention stated that 91 Americans lose their lives daily due to an overdose of opioid drugs. This public health crisis has inspired much apprehension even among Haitian diaspora in the United States. Although needed painkillers are notably lacking in developing countries, the fear of a similar path has led a high-profile personality to advise against their use in Haiti. Indeed, he...
Source: Kevin, M.D. - Medical Weblog - February 20, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/kenny-moise" rel="tag" > Kenny Moise, MD < /a > Tags: Policy Pain Management Primary Care Source Type: blogs

Fermented foods to beat back SIBO and dysbiosis
If you’ve been following the Wheat Belly discussions, you already know that efforts to cultivate healthy bowel flora in the wake of wheat/grain elimination is a key factor in regaining health. While I’ve emphasized the importance of a high-potency (e.g., 50 billion or more CFUs per day), multi-species probiotic supplement and prebiotic fibers, I’ve not focused on the importance of fermented foods. This issue comes to light in particular with our experience in battling small intestinal bacterial overgrowth, or SIBO. Dysbiosis, or disrupted composition of bowel flora in the colon, is exceptionally common, e...
Source: Wheat Belly Blog - February 19, 2018 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle bowel flora fermented foods grain-free Inflammation kefir kimchi kombucha probiotic sibo small intestinal bacterial overgrowth yogurt Source Type: blogs

The Skeptical Oncologist
By BISHAL GYAWALI, MD Why conduct post approval studies at all? Atezolizumab previously received accelerated approval in second-line metastatic or advanced urothelial cancer based on response rates from a single arm trial. The results of post approval confirmatory phase 3 are now published and demonstrate that atezolizumab did not improve survival versus chemotherapy (11.1 v 10.6 months, HR 0.87, p = 0.41). The concept of accelerated approval is to grant early and conditional approval and access to drugs in diseases of unmet need, and that the decision to fully approve or revoke be made based on results of confirmato...
Source: The Health Care Blog - February 7, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

Precision Medicine and Public Health (from Precision Medicine and the Reinvention of Human Disease)
Excerpted fromPrecision Medicine and the Reinvention of Human DiseaseDespite having the most advanced healthcare technology on the planet, life expectancy in the United States is not particularly high. Citizens from most of the European countries and the highly industrialized Asian countries enjoy longer life expectancies than the United States. According to the World Health Organization, the United States ranks 31st among nations, trailing behind Greece, Chile, and Costa Rica, and barely edging out Cuba [42]. Similar rankings are reported by the US Central Intelligence Agency [43]. These findings lead us to infer that acc...
Source: Specified Life - February 6, 2018 Category: Information Technology Tags: cancer cancer vaccines precision medicine prevention public health Source Type: blogs

Early Detection
We do regularly try to detect some cancers early through mammograms, colonoscopies, and PSA tests. I think most of us (meaning the general public) are comfortable with these tests as we age. But what if there was a genetic test available which you could have done regularly, every few years or whatever time frame, to test you for several different cancers before they had a chance to spread.A new test,CancerSEEK, has been tested on more than 1000 patients and seems very hopeful." The CancerSEEK test looks for mutations in 16 genes that regularly arise in cancer and eight proteins that are often released.It was trialled on 1,...
Source: Caroline's Breast Cancer Blog - January 20, 2018 Category: Cancer & Oncology Tags: cancer detection cancer diagnosis medical tests Source Type: blogs

New Electronic Pill Monitors Gas Contents of Guts
The goings on deep inside our guts are still very much shrouded in mystery. The mystery arises partially from the fact that it’s hard to sample the gasses that exist inside our bowels. Much of our knowledge about the gaseous content of the GI s...
Source: Medgadget - January 16, 2018 Category: Medical Devices Authors: Editors Tags: GI News Source Type: blogs

Doctors, Data, Diagnoses, and Discussions: Achieving Successful and Sustainable Personalized/Precision Medicine
The following is a guest blog post by Drew Furst, M.D., Vice President Clinical Consultants at Elsevier Clinical Solutions. Personalized/precision medicine is a growing field and that trend shows no sign of slowing down. In fact, a 2016 Grand View Research report estimated the global personalized medicine market was worth $1,007.88 billion in 2014, with projected growth to reach $2,452.50 billion by 2022. As these areas of medicine become more commonplace, understanding the interactions between biological factors with a range of personal, environmental and social impacts on health is a vital step towards achieving sustaina...
Source: EMR and HIPAA - January 10, 2018 Category: Information Technology Authors: Guest Blogger Tags: Clinical Decision Support Genomics Healthcare HealthCare IT Personalized Medicine Drew Furst Elsevier Elsevier Clinical Solutions Precision Medicine Source Type: blogs

The Price of Progress
By ANISH KOKA, MD No one knows who Bennie Solis is anymore. He had the misfortune of being born in the early 1960s marked for death. He had a rare peculiar condition called biliary atresia – a disease defined by the absence of a conduit for bile to travel from his liver to his intestinal tract. Bile acid produced in the liver normally travels to the intestines much like water from a spring travels via ever larger channels to eventually empty into the ocean. Bile produced in the liver with no where to go dams up in the liver and starts to destroy it. That the liver is a hardy organ was a fact known to the ancient Gree...
Source: The Health Care Blog - January 4, 2018 Category: Consumer Health News Authors: anish_koka Tags: Uncategorized Source Type: blogs