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Are there Commonalities Between Neurodegenerative Conditions that can be Targeted to Produce General Therapies?
In this study, we utilized an imaging-based assay to monitor the ability of disease-associated amyloid assemblies to rupture intracellular vesicles following endocytosis. We observe that the ability to induce vesicle rupture is a common feature of α-synuclein (α-syn) assemblies, as assemblies derived from wild type (WT) or familial disease-associated mutant α-syn all exhibited the ability to induce vesicle rupture. Similarly, different conformational strains of WT α-syn assemblies, but not monomeric or oligomeric forms, efficiently induced vesicle rupture following endocytosis.
The ability to induce vesicle rupt...
Source: Fight Aging! - May 24, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Bob Wachter ’ s 2017 Penn Med Commencement Address “ Go to Radiology ”
By ROBERT WACHTER, MD
Dean Jameson, Trustees, Faculty, Family and Friends, and most of all, Graduates of the Class of 2017:
Standing before you on this wonderful day, seeing all the proud parents and significant others, I can’t help but think about my father. My dad didn’t go to college; he joined the Air Force right after high school, then entered the family business, which manufactured women’s clothing. He did reasonably well, and my folks ended up moving to a New York City suburb, where I grew up.
There were a lot of professionals in the neighborhood, but my dad admired the doctors the most. He was even a little e...
Source: The Health Care Blog - May 17, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Penn Radiology Robert Wachter Speeches UCSF Source Type: blogs
Stop the s.-shaming: HPV vaccines prevent cancer
I met “Samantha” during my first rotation as an intern. She was a strong-willed and optimistic lady who weighed about 100 pounds. She was dependent on a tube in her stomach for nutrition, and she appeared 10 or 15 years older than her age of 44 years. Pictures of her children were next to her bed. I asked her how we could help her. She cried.
Her husband of 20 years was by her side and answered for her. “She wants to eat again,” he stated. Her tears worsened.
The problem is that Samantha would probably not tolerate normal food again because her digestive organs were permanently damaged from radiation to her abdomen...
Source: Kevin, M.D. - Medical Weblog - May 1, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/cory-michael" rel="tag" > Cory Michael, MD < /a > Tags: Conditions Pediatrics Source Type: blogs
The Good, The Bad, and The Ugly
So my life is having its normal ups and downs. There are definitely the good, the bad, and the ugly.What is good? A whole bunch of things:I actually got enough sleep for a couple of nights. I slept late two days this week which helped. Spring is actually springing. I planted some spinach and peas. Both are cold weather tolerant. Spinach actually will not grow in the heat of the summer. I finally see some progress on my SSDI claim. This means I actually heard back from SSDI for more information for the first time in six months. My husband and I went to the beach for a day last weekend when it was 80 degrees.&...
Source: Caroline's Breast Cancer Blog - April 22, 2017 Category: Cancer & Oncology Tags: being a patient life Source Type: blogs
10 Things Every Alzheimer's Caregiver Needs to Know and Discuss with Their Doctor
TheAmerican Geriatrics Society has published a list of ten things doctors and their patients should consider, know and understand.I think it is important forevery caregiver of a person living with Alzheimer's, or a related dementia, todiscuss these 10 issues with the doctor. Doing this in advance might be one of the most important caregiverdecisions you can make.It might also be a good idea toshare this article in support groups, and bookmark (save) it so you can find it when you need it.What is Alzheimer's Disease?By Carole Larkinhttp://www.alzheimersreadingroom.comI think this is an important list of things that nee...
Source: Alzheimer's Reading Room, The - April 13, 2017 Category: Neurology Authors: rtdemarco at gmail.com Tags: alzheimer care care of dementia patients dementia help for caregivers elderly dementia care geriatrics health help alzheimer's help with dementia help with dementia care life news memory care facility Source Type: blogs
Another Try At Being A Normal Person
Yesterday wasn ' t the greatest day. Between going to the walk in clinic for my stupid tick bite and the antibiotic that upset my stomach, I wasn ' t as productive as I might want to be. So today I plan on attempting to be a normal person again. It shouldn ' t be that difficult but you never know with me.My plans are to warp my loom for another project, meet a friend at noon to go see another friend ' s new garden center, and then maybe one more errand when I get home from that. Any bets on whether I can make it?I just get very frustrated by trying to be a normal person and ending up spending a day or two or three recoveri...
Source: Caroline's Breast Cancer Blog - April 9, 2017 Category: Cancer & Oncology Tags: annoyance frustration normal Source Type: blogs
Being High Risk
Normal people get exposed to something and they get told ' call us if there are any changes in whatever it is that is bothering them ' . They get sent home basically with a ' take two options and call me in the morning ' .Me? I ' m not a normal person. With my medical history? Of course not.We live in a wooded area with lots of deer and mice outside. Our two cats like to go in and out and in and out and in and out. They bring us home presents and usually leave them outside. But sometimes they don ' t.Yesterday I came home from the gym and took a shower. The cats went in and out and in and out. I decided it was time to trea...
Source: Caroline's Breast Cancer Blog - April 8, 2017 Category: Cancer & Oncology Tags: ailments Lyme disease Source Type: blogs
H. pylori, a true stomach “bug”: Who should doctors test and treat?
In 1982, two Australian scientists discovered that a certain bacterium, Helicobacter pylori, was a common cause of persistent stomach inflammation and stomach ulcers. This realization revolutionized ulcer treatment.
While fairly common, this infection usually causes no symptoms, but it can sometimes lead to ulcers in the stomach or the very first part of the small intestine (duodenum), and to certain types of stomach cancer. There is also evidence linking H. pylori infection to other conditions like iron-deficiency anemia and vitamin B12 deficiency. The bacteria are thought to spread through contaminated water, vomit, or f...
Source: Harvard Health Blog - April 5, 2017 Category: Consumer Health News Authors: Wynne Armand, MD Tags: Digestive Disorders Health Infectious diseases Tests and procedures Source Type: blogs
If you have low back pain try these steps first
Low back pain, the scourge of mankind: it is the second leading cause of disability here in the United States, and the fourth worldwide. It’s also one of the top five medical problems for which people see doctors. Almost every day that I see patients, I see someone with back pain. It’s one of the top reasons for lost wages due to missed work, as well as for healthcare dollars spent, hence, a very expensive problem.
Looking at two kinds of back pain
Let’s talk about the most common forms of back pain: acute (which lasts less than four weeks) and subacute (which lasts four to 12 weeks). Most of these cases (approximate...
Source: Harvard Health Blog - April 3, 2017 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Back Pain Managing your health care Pain Management Source Type: blogs
Is there HEALING in healthcare?
Has the idea of healing people back to health been lost from modern healthcare?
Have you seen all those billboards and ads luring you into hospitals, surgeries, and other high-ticket medical procedures? Why run ads for electrophysiologic studies, implantable defibrillators, lap-band/gastric bypass, and cancer chemotherapy?
Easy: Because that’s where the money is.
If healing were truly the driving theme behind today’s healthcare, then the whole approach would be different. Conversations with health care providers would focus on prevention and identifying and reversing causes instead of expensive procedures.
The...
Source: Wheat Belly Blog - April 3, 2017 Category: Cardiology Authors: Dr. Davis Tags: Undoctored health healthcare healthcare costs predatory Source Type: blogs
Fight Aging! Newsletter, April 3rd 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - April 2, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Funtabulously Frivolous Friday Five 183
LITFL: Life in the Fast Lane Medical Blog
LITFL: Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 183.
Question 1
The restaurant preparation of fugu is strictly controlled by law in Japan, and only chefs who have qualified after three or more years of rigorous training are allowed to prepare the fish. What dish in Egypt is less well controlled and has resulted in deat...
Source: Life in the Fast Lane - March 31, 2017 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five albert stevens bacon boil botfly botulism fesikh furuncular myiasis manhattan project obecalp placebo plutonium radiation second fracture Source Type: blogs
Your First Colonoscopy! What to Expect
Whee! Time for a Tube Up Your Tuchus!image:wikimedia commonsBy Crabby McSlackerSo, some perspective here: for people with serious illnesses who've been through hardcore, painful, debilitating, invasive medical procedures? A colonoscopy is probably child's play. (Although let's be clear, that's just an expression. If your child actually plays this way? We need to talk).But for most people, there's at least a little trepidation. And for many, if statistics are to be believed, that fear is significant enough to skip the procedure entirely! Well sure, it could save your life and all, but really? Do you have to?There are actual...
Source: Cranky Fitness - March 12, 2017 Category: Consumer Health News Authors: Crabby McSlacker Source Type: blogs
More about Virtue Sweetener
Because I wanted a benign and healthy way for followers of the Wheat Belly lifestyle to recreate dishes such as chocolate chip cookies, cheesecake, and pies with none of the health problems of grains or sugars, I helped Wheat-Free Market develop its Virtue Sweetener product.
Yes, you could do without such sweeteners. But I learned long ago when I introduced Wheat Belly concepts to patients in my cardiology practice that having options while entertaining friends, during holidays, and pleasing kids was important for staying on course on this lifestyle. Before I understood how to use such natural sweeteners, patients would ...
Source: Wheat Belly Blog - March 10, 2017 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle diabetes erythritol gluten grains Inflammation insulin keto low-carb monk fruit natural virtue sweetener Source Type: blogs
Multigene Panel Testing for Patients with Early-Onset Cancer of the Colon
In a recent note, I discused some theories about why the incidence of colonic cancer is increasing in younger patients (see:Why the Increased Incidence of Colonic Cancer Among Younger Americans?). Continuing in this same vein, a recent article I came across raised the issue of multigene panel testing to reveal genetic mutations in the roughly one-third of patents with early onset colonic cancer (see:Multigene Panel Testing Reveals Mutations in One-Third of Early Onset CRC Patients). Below is an excerpt from the article:Although the overall incidence of colorectal cancer (CRC) has been decreasing in the Un...
Source: Lab Soft News - March 7, 2017 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Lab Industry Trends Lab Processes and Procedures Medical Research Preventive Medicine Source Type: blogs
