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In Vivo Cell Reprogramming as a Path to Rejuvenation
Reprogramming of ordinary somatic cells into induced pluripotent stem cells (iPSCs) capable of generating any cell type is very much a going concern these days. The first cell therapies based on the transplantation of patient-matched cells derived from iPSCs are entering trials. More recently, however, researchers have been experimenting with the more radical idea of reprogramming cells in situ, in tissues. At first glance (and later consideration) this seems enormously risky, a fast path to cancer. Yet in mouse studies it appears, at least initially, to be quite beneficial. It will take a great deal more data to overcome ...
Source: Fight Aging! - December 24, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The Bovine Guide to Healthy Eating
Grains are seeds of grasses. They, along with the Kentucky bluegrass and rye grass in your lawn, are plants from the family Poaceae, the grasses of the earth. Grasses are so ubiquitous and prolific that creatures have evolved that are able to survive by consuming them as their main source of food.  Ruminants such as cows, goats, sheep, giraffes, gazelle, and antelopes are able to digest grasses because they have undergone extensive evolutionary adaptation over millions of years that allow them to subsist on grasses as a food supply. For instance, ruminants: Grow teeth continuously to compensate for the wear caused by s...
Source: Wheat Belly Blog - December 19, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates Gliadin gluten grain grain-free grains Inflammation wheat belly Source Type: blogs

Heart failure and salt: The great debate
“Let there be work, bread, water, and salt for all.” — Nelson Mandela Salt: without it, food can seem tasteless. It is the reason sea water burns our eyes and skin. Some people enjoy salt water baths. Is it good for us? Is it not? Do we really know? In modern medicine, we tend to have a generally negative feeling about sodium, the element found in salt. Excessive sodium intake is linked to water retention, and it is also a risk factor for high blood pressure. Both excessive sodium intake and high blood pressure are major risk factors for developing heart failure, and for causing complications in those with existing h...
Source: Harvard Health Blog - December 18, 2018 Category: Consumer Health News Authors: James Januzzi, MD Tags: Diet and Weight Loss Health Healthy Eating Heart Health Source Type: blogs

Fight Aging! Newsletter, December 10th 2018
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging. Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/ Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the con...
Source: Fight Aging! - December 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Horrors of Gluten-Free Food
It continues to happen: I run into people who say to me “I follow the Wheat Belly lifestyle. I eat gluten-free!” When I ask them what that means, they tell me that they only eat gluten-free bread, pasta, pizza, cookies, etc. I’m not entirely sure why this misinterpretation of the Wheat Belly message is so common. Let’s talk about this important distinction, as being gluten-free can be an absolute health and weight disaster, unlike the magnificent health and weight loss we enjoy on the Wheat Belly lifestyle when done right. It’s perfectly fine to be gluten-free, i.e., avoiding wheat, rye, and b...
Source: Wheat Belly Blog - December 5, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates autoimmune blood sugar gluten gluten-free grain grain-free grains Weight Loss wheat belly Source Type: blogs

Last Month in Oncology with Dr. Bishal Gyawali
By BISHAL GYAWALI MD Me-too deja vu I read the report of a phase 3 RCT of a “new” breast cancer drug but I had the feeling that I had already read this before. Later I realized that this was indeed a new trial of a new drug, but that I had read a very similar report of a very similar drug with very similar results and conclusions. This new drug is a PARP inhibitor called talazoparib and the deja vu was related to another PARP inhibitor drug called olaparib tested in the same patient population of advanced breast cancer patients with a BRCA mutation. The control arms were the same: physician choice of drug, except t...
Source: The Health Care Blog - November 8, 2018 Category: Consumer Health News Authors: matthew holt Tags: Drug Discovery Pharmaceuticals Bishal Gyawali Cancer immunotherapy Oncology Source Type: blogs

What happened to the grasshoppers?
When I was a kid, grasshoppers were everywhere. I walked through a field every day to get to school and grasshoppers were everywhere, jumping back and forth across my path, frequently banging off my legs. At night in summer, the backyard was filled with fireflies that we’d chase and capture in jars to watch up close. And there were butterflies of many colors and varieties everywhere, flitting from flower to flower. Today, I don’t see any grasshoppers. In fact, I haven’t seen one in over 40 years. I saw one—just one—firefly this past summer in my backyard. And I can count the number of butterie...
Source: Wheat Belly Blog - October 22, 2018 Category: Cardiology Authors: Dr. Davis Tags: Agribusiness bowel flora Inflammation microbiota prebiotic probiotic wheat belly Source Type: blogs

Unexpected Lessons Learned From the Wheat Belly Lifestyle
In the seven years since the original Wheat Belly book hit bookstores and turned the nutritional world topsy-turvy and millions of people have engaged in a grain-free lifestyle, many unique lessons have been learned. Even though I had engaged the practices of this lifestyle for a number of years and in thousands of people before I broadcast these ideas through books, expanding the audience to many more people yielded feedback on an enormous scale, new lessons that even surprised me. Among the new lessons learned along the way: Plantar fasciitis—I did not expect to have so many people report that this painful condition t...
Source: Wheat Belly Blog - October 17, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates bowel flora gluten gluten-free grain-free grains Inflammation Weight Loss Source Type: blogs

Aspirin for primary prevention of cardiovascular disease, part 2
Well, it seems as though not even a week can go by without more data on aspirin! I recently reviewed the ARRIVE trial and the implications for primary prevention — that is, trying to prevent heart attacks and strokes in otherwise healthy people. Since then, yet another large clinical trial — the ASPREE study — has come out questioning the use of aspirin in primary prevention. Three articles pertaining to this trial were published in the prestigious New England Journal of Medicine, which is an unusual degree of coverage for one trial and highlights its immediate relevance to clinical practice. Aspirin still strongly i...
Source: Harvard Health Blog - September 25, 2018 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Heart Health Prevention Source Type: blogs

FDA permits marketing of new endoscopic device for treating gastrointestinal bleeding
The U.S. Food and Drug Administration permitted marketing of Hemospray, a new device used to help control certain types of bleeding in the gastrointestinal (GI) tract.“The device provides an additional, non-surgical option for treating upper and lower GI bleeding in certain patients, and may help reduce the risk of death from a GI bleed for many patients,” said Binita Ashar, M.D., director, division of surgical devices, in the FDA’s Center for Devices and R adiological Health.GI bleeding can occur in the upper GI tract (esophagus, stomach or small intestine) or the lower GI tract (colon and rectum). Causes of GI blee...
Source: Medical Hemostat - September 23, 2018 Category: Medical Devices Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

PCOS: A man-made situation
Most mainstream doctors believe that polycystic ovary syndrome, PCOS, is a disease. PCOS is, after all, associated with markedly increased risk for type 2 diabetes, hypertension, endometrial cancer, and heart disease, in addition to outward signs that include excessive facial and body hair, tendency to being overweight or obese, irregular menstrual cycles, infertility. A crisis of self esteem commonly and understandably results. Mainstream doctors tell you to not worry because they have plenty of prescription drugs to “treat” it, not to mention various hormones, fertility procedures, and gastric bypass. PCOS is a situa...
Source: Wheat Belly Blog - September 6, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates acne facial change facial hair gluten-free grain-free grains Inflammation pcos polycystic ovary testosterone undoctored Weight Loss wheat belly Source Type: blogs

Primary care pediatrics is more than medicine  : It is a calling
I have been working in pediatric primary care for nearly 5 years post-residency and truly love my work. I currently am dealing with very painful post-herpetic neuralgia and many people with this quit working. At some personal cost, I have continued my practice because I find my work day so rewarding I simply can’t imagine not being a practicing pediatrician. On a given day I might see a newborn fresh from the nursery or NICU and its exhausted but joyful parents and then next see a college student exploring a transgender identity. I might splint a finger, manage a childhood cancer survivor, do a well-child check, treat al...
Source: Kevin, M.D. - Medical Weblog - September 4, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/heather-finlay-morreale" rel="tag" > Heather Finlay-Morreale, MD < /a > Tags: Physician Pediatrics Primary Care Source Type: blogs

MRI Uncovers Missing Contact Lens Found 28 Years Later in Patient ’s Upper Eyelid
In Scotland, a contact lens that had gone missing for nearlythree decades was finally located when the owner of the lens underwent a MRI for upper eyelid swelling and ptosis.The MRI had indicated a cyst with proteinaceous content. When surgeons made an excision of the cyst, a rigid gas permeable (RGO) lens was discovered, deep in the upper eyelid soft tissue.“The features on the MRI were in keeping with a cyst with proteinaceous content. There were no radiological features of a foreign body seen within the cyst,” wrotethe patient ’s ophthalmologists in a report published in BMJ Case Reports.The disappearance of the...
Source: radRounds - August 30, 2018 Category: Radiology Authors: Julie Morse Source Type: blogs

The Abscopal Effect
In the waning years of my career as a Nuclear Radiologist, I have become somewhat more jaded than I was as a younger doc. When you see cancer and other diseases fifty times a day, sometimes getting better, sometimes getting worse, that ' s bound to happen. Of course, I ' m far prefer reporting improvement, but relapses are also part of this job. The oncologists wander into the reading room every few minutes, or so it seems, anyway, to look at their patients ' scans (the gantry is generally still warm). If the news is bad, I will tell them in all honesty that I admire the strength it will take to deliver the bad news. On th...
Source: Dalai's PACS Blog - August 19, 2018 Category: Radiology Source Type: blogs

Susanne: Goodbye, gluten-free
It’s no exaggeration to say that lives are transformed by the Wheat Belly lifestyle. Look what happened to Susanne after her health was ruined by being gluten-free, reversed by following the Wheat Belly 10-Day Grain Detox. Food manufacturers, out of ignorance or ruthless profiteering, have chosen to replace wheat and gluten with cornstarch, rice flour, tapioca starch, or potato starch—among the few foods that provoke high blood sugar and insulin more than even our favorite grain to bash, wheat. It means that people who are gluten-free and consume such garbage replacement products gain weight in visceral inflamm...
Source: Wheat Belly Blog - August 12, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates Detox gluten-free grain-free grains Inflammation Weight Loss Source Type: blogs