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Fight Aging! Newsletter, May 22nd 2017
In this study, researchers analysed data of millions of British patients between 1995 and 2015 to see if this claim held true. They tracked people who were obese at the start of the study, defined as people with a body mass index (BMI) of 30 or more, who had no evidence of heart disease, high blood pressure, high cholesterol or diabetes at this point. They found these people who were obese but "metabolically healthy" were at higher risk of developing heart disease, strokes and heart failure than people of normal weight. No such thing as 'fat but fit', major study finds Several studies in the past have sug...
Source: Fight Aging! - May 21, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Bioprinted Artificial Ovaries Demonstrated to be Fully Functional in Mice
Researchers cannot yet produce large amounts of tissue using tissue engineering approaches such as bioprinting, as there is still no good solution for the creation of a suitable blood vessel network to support sizable tissue sections. However, that hasn't stopped the research community from forging ahead to develop the necessary recipes to produce functional tissue of various types, just in very small amounts. In many cases this artificial tissue isn't exactly the same in structure as the tissue it replaces, but it is nonetheless still capable of carrying out the desired functions. Some organs or crucial parts of organs ar...
Source: Fight Aging! - May 17, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Printing a 3D ovary to treat infertility
Scientists have used a 3D printer to make a scaffold of a soft plastic type material known as a hydrogel. The researchers then loaded this scaffold with the egg sacs known as ovarian follicles from a female mouse and implanted it. The follicles began maturing and released eggs, which were fertilised by natural mating and the mice then went on to give birth to live young. [Laronda et al, Nature Commun, 2017, DOI: 10.1038/ncomms15261]. A similar synthetic ovary might one day be used to treat infertility in women who have had cancer chemotherapy. Chemotherapy causes ovarian failure, essentially destroying a woman’s egg...
Source: David Bradley Sciencebase - Songs, Snaps, Science - May 17, 2017 Category: Science Authors: David Bradley Tags: Cancer Science Source Type: blogs

Reducing IVF anxiety
Lots of patients are very scared of doing IVF. This is partly because they've heard lots of horror stories about how IVF babies are abnormal, or that the hormones will make them fat, or that if they grow too many eggs, they will either get menopausal sooner, or start getting ovarian cancer as they grow older. And, they've heard lots of horror stories from some of their friends, who've done IVF, about how painful the injections can be, or how many mood swings it causes, or the fact that you need bed rest or that there are lots of complications, or that the risk of miscarriage is higher after IVF.There are lots of myths and ...
Source: Dr.Malpani's Blog - May 17, 2017 Category: Reproduction Medicine Source Type: blogs

Fertility: 12 things you didn ’t know (and 1 to never ask)
By Katrina Mark, MD 1. Fertility naturally declines as we age That alone doesn’t mean you should start to worry. The general advice I give a woman is if she has been trying to become pregnant for a full year with no luck, she might consider a fertility evaluation. For a woman over age 35, she might consider it after six months. If a woman is younger and has irregular periods, it’s likely she isn’t regularly ovulating, so she might want to be evaluated sooner. 2. Sometimes there’s a reason for infertility – and sometimes, there’s not There are some things we know cause infertility. About 20 percent of the time,...
Source: Life in a Medical Center - May 2, 2017 Category: Universities & Medical Training Authors: UMMC Tags: Health Tips Women's Health fertility Katrina Mark obgyn UMMC Source Type: blogs

Telling Daughters About Their Genetic Breast Cancer Risk
We are now in the era of predictive medicine when many of us will have theopportunity to learn about our individual predisposition to develop serious diseases at some point in our lives. This is now a reality for families carrying the BRCA gene (females as well as males) (see:BRCA-Positive Males at Higher Risk for Prostate and Pancreatic Cancer). This topic was discussed in a recent article in theNew York Times. An excerpt from the article is listed below (see:When to Tell Daughters About a Genetic Breast Cancer Risk):As genetic testing has given women and men a trove o...
Source: Lab Soft News - April 25, 2017 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Lab Industry Trends Lab Information Medical Consumerism Medical Education Medical Ethics Source Type: blogs

Dueling BRCA Databases: What About the Patient?
The news release Monday morning grabbed my attention: “Study finds wide gap in quality of BRCA1/2 variant classification between Myriad Genetics and a common public database.” Myriad Genetics had been exclusively providing tests, for $3000+ a pop for full BRCA gene sequencing, for 17 years before the Supreme Court invalidated key gene patents back in 2013. Since the ruling a dozen or so competitors have been offering tests for much lower prices. Meanwhile, Myriad has amassed a far deeper database than anyone else, having been in the business so much longer. And it’s proprietary. CLASSIFYING GENE VARIANTS ...
Source: blog.bioethics.net - April 20, 2017 Category: Medical Ethics Authors: Bioethics Today Tags: Health Care syndicated Source Type: blogs

Physicians can choose to nurture their human side
A keynote address to Gold Humanism Honor Society Induction Ceremony, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA. As an intern, I was assigned to 9 weeks over the year on the bone marrow transplant inpatient unit.  It was medically fascinating but emotionally draining and anxiety provoking.  I began to get nauseated going to work because I was having such a hard time with the rotation.  As I sank deeper into anxiety and self-doubt as patient after patient died or had terrible complications, I met a patient who forever changed my attitude towards humanism in medicine, and I’d like to te...
Source: Kevin, M.D. - Medical Weblog - April 12, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/gretchen-diemer" rel="tag" > Gretchen Diemer, MD < /a > Tags: Physician Primary care Source Type: blogs

Fight Aging! Newsletter, April 10th 2017
This study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined age-assoc...
Source: Fight Aging! - April 9, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Precision Medicine Is Our Best Hope In The Fight Against Cancer
In the fight against cancer, precision medicine is one of the most promising tools and the logical outcome of current healthcare trends. As start-ups offering personalized healthcare solutions multiply like mushrooms after rain, governments and regulatory agencies have to give appropriate responses in regulating the grass-root healthcare jungle. Here is my analysis about the potential and dilemmas about precision medicine. Precision medicine is the logical outcome of modern healthcare There is one phrase, which is not part of the Hippocratic Oath, but everyone in medicine knows it. Primum non nocere, meaning “first do n...
Source: The Medical Futurist - March 30, 2017 Category: Information Technology Authors: nora Tags: Future of Medicine Genomics Healthcare Design Personalized Medicine AI cancer cancer research chemotherapy digital gc4 genetics Genome Innovation oncology precision medicine targeted treatment technology Source Type: blogs

If Everything Took 15 Minutes: Considering Time
I always thought about time —How long until we get there, Mommy and Daddy? . . .Fifteen minutes, Benjamin . . .no matter the destination, my parents always proclaimed the car ride would take 15 minutes —but time assumed new significance when I was 16.I remember, then, scanning the ceiling and thinking about time. Unlike my bedroom nowadays, in which even my computer ’s LED light is covered with a blackout sticker, my hospital room dazzled with light streaming in through the door’s small window and from the IV machine’s red digits telling me fluid was entering my bloodstream at 150 milliliters an hour. The light p...
Source: cancerslayerblog - March 21, 2017 Category: Cancer & Oncology Tags: life lessons MFA Source Type: blogs

What Can Women Do to Prevent Early Menopause?
About Early Menopause The average age a woman goes into menopause is 51. Menopause is considered abnormal when it begins before the age of 40 and is called “premature ovarian failure.” Common symptoms that come with menopause include hot flashes, night sweats, sleep problems, sexual issues, vaginal dryness, pain during sex, pelvic floor disorders (urine, bowel leakage, pelvic organ prolapse), losing bone mass, and mood swings. Menopause is mostly genetically predetermined, which means you generally can’t do much to delay it from happening. What we can do is work to counter-balance or prevent the symptoms and effe...
Source: Life in a Medical Center - March 13, 2017 Category: Universities & Medical Training Authors: UMMC Tags: Health Tips Women's Health diet and exercise early menopause tatiana sanses Source Type: blogs

Why aren ’t women receiving appropriate genetic counseling?
This study makes the difficult point that when it comes to routine screening for genetic abnormalities in women (and men, for that matter) who may be at increased risk, we simply aren’t doing the job. The situation may well be worse than this report suggests, especially considering that in some areas of the country Medicare doesn’t even cover preventive testing for the BRCA mutation. And this is more than 20 years after the test was first discovered and placed into clinical practice. I guess sometimes it takes a long time for the way we care for our patients to catch up with the science that we know works. But twenty y...
Source: Kevin, M.D. - Medical Weblog - March 9, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/j-leonard-lichtenfeld" rel="tag" > J. Leonard Lichtenfeld, MD < /a > Tags: Conditions Cancer Genetics Source Type: blogs

Multigene Panel Testing for Patients with Early-Onset Cancer of the Colon
In a recent note, I discused some theories about why the incidence of colonic cancer is increasing in younger patients (see:Why the Increased Incidence of Colonic Cancer Among Younger Americans?). Continuing in this same vein, a recent article I came across raised the issue of multigene panel testing to reveal genetic mutations in the roughly one-third of patents with early onset colonic cancer (see:Multigene Panel Testing Reveals Mutations in One-Third of Early Onset CRC Patients). Below is an excerpt from the article:Although the overall incidence of colorectal cancer (CRC) has been decreasing in the Un...
Source: Lab Soft News - March 7, 2017 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Lab Industry Trends Lab Processes and Procedures Medical Research Preventive Medicine Source Type: blogs

A Million Jobs in Healthcare ’ s Future
By PRAVEEN SUTHRUM “The Future is Here. It’s Just Not Evenly Distributed.” It’s true. Science fiction writer William Gibson said that right. We simply have to look around enough – now – to find out what the future holds. The future may never be evenly distributed. But it’s surely becoming the present faster. What would you do when… Here are a series of what-would-you-do-when questions to think about. Each of these are a reality today, somewhere. There’s more medical data than insight Kaiser Permanente presently manages 30 petabytes of data. Images. Lab tests. EHRs. Pat...
Source: The Health Care Blog - February 21, 2017 Category: Consumer Health News Authors: John Irvine Tags: Tech Uncategorized Source Type: blogs