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My Infertility Journey as a Woman in Medicine
Editor’s Note: For more on the challenges as well as strategies to address physician infertility, please read this Academic Medicine Invited Commentary, cowritten by the author of this blog post. Most of us in medicine pride ourselves on being organized, detail-oriented, conscientious and able to achieve excellent results with enough hard work—and are not used to failure and loss of control. My experience with infertility has been the first time that I truly experienced failure and complete loss of control, realizing that fertility is not a merit-based system. No matter how hard I try, how many doctors I cons...
Source: Academic Medicine Blog - March 11, 2020 Category: Universities & Medical Training Authors: Guest Author Tags: Featured Guest Perspective infertility physician well-being women in academic medicine Source Type: blogs

Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

MR1 as a Broad Signature of Cancer, Suitable for T Cell Targeting
Meaningful progress towards the control of cancer, ending it as a major threat to life and health, will be led by programs that can produce very broadly applicable treatments. That means therapies that can be applied to many (or even all) cancers with minimal differences in configuration or need for further per-cancer development. There are hundreds of cancer subtypes, but only so many researchers, and only so much funding for research and development: development of highly specific therapies is just not an effective path forward. Examples of the most promising lines of work with broad application include the OncoSe...
Source: Fight Aging! - January 22, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Researchers urge prostate cancer screening for men with BRCA gene defects
Prostate cancer screening with the prostate-specific antigen (PSA) test has been criticized for flagging too many slow-growing tumors that might never be life-threatening. But some men have inherited gene defects that boost their risk of developing prostate cancers that can be quite aggressive. Is PSA screening particularly well-suited for these genetically defined groups? New research suggests the answer is yes. In November, a team of British scientists released highly anticipated findings from a study of PSA screening in men with defects in a pair of important genes called BRCA1 and BRCA2. Better known for increasing the...
Source: Harvard Health Blog - December 20, 2019 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Prostate Knowledge Screening HPK Source Type: blogs

Fight Aging! Newsletter, December 16th 2019
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - December 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Large Study of Aspirin Use Finds Reduced Mortality, Contradicting the Recent ASPREE Study Results
The back and forth over whether regular aspirin use is beneficial continues with the publication of results from analysis of a large patient population that show a 15% reduction in all cause mortality in patients using aspirin. This contradicts the much smaller (but still large in and of itself) ASPREE clinical trial, in which patients using aspirin exhibited a small increase in mortality in comparison to their peers. As in that earlier study, the data here strongly suggests that benefits and risks vary with patient characteristics, such as whether or not a patient is overweight. Aspirin is thought to be a weak calo...
Source: Fight Aging! - December 13, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

No More Clitting Around: Let ’s Talk about Clitoris Transplants
Quality of life transplantations (e.g. hand, face, etc.), in contrast to life-saving transplantations (e.g. heart, lungs, etc.), have become increasingly popular and have gained more acceptance in the medical and lay communities. In the last two decades transplants for sexual and reproductive organs—specifically allogenic transplantations of the uterus, ovary, and penis—have emerged as yet another type of quality of life transplants. The purpose of uterus transplantations is to allow cisgender women with absolute uterine factor infertility to experience pregnancy. Although the first uterus transplantation took ...
Source: blog.bioethics.net - September 17, 2019 Category: Medical Ethics Authors: Bioethics Today Tags: Health Care assisted reproduction feminist ethics reproductive medicine Sex and Sexuality surgical ethics syndicated transplantation Women's Reproductive Rights Source Type: blogs

Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Hospice Expert Shares Her Death Online
Virginia Public Radio does a nice job describing how Kathy Brandt used social media to share her dying from ovarian cancer. The compelling story has also been nicely covered by Kaiser Health News and others.
Source: blog.bioethics.net - August 17, 2019 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs

Like CD47, CD24 Also Acts as a " Don ' t Eat Me " Signal and is Abused by Cancer Cells
Cancer cells abuse signals used elsewhere in normal mammalian biochemistry to prevent immune cells from destroying other cells, such as CD47. Interfering in these "don't eat me" signals has produced significant gains in the development of effective cancer therapies that can target multiple types of cancer. Here, researchers describe a newly discovered "don't eat me" signal, CD24, that should allow this class of cancer therapy to be expanded to target cancers that have proved resilient to existing implementations. This and related lines of work that lead to more general anti-cancer platforms are one of the reasons why young...
Source: Fight Aging! - August 14, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Live-Tweeting About Dying: Last Lessons from Kathy Brandt
Kathy Brandt, a leader in the hospice and palliative care movement in the United States, died on August 4. She was 53 and had been diagnosed with a rare, highly aggressive form of ovarian cancer in January. Brandt and her wife regularly posted on social media about their family's end-of-life experiences. The post Live-Tweeting About Dying: Last Lessons from Kathy Brandt appeared first on The Hastings Center.
Source: blog.bioethics.net - August 6, 2019 Category: Medical Ethics Authors: Susan Gilbert Tags: Health Care Chronic Conditions and End of Life Care Hastings Bioethics Forum hospice palliative care social media syndicated Source Type: blogs

Remembering Kathy Brandt: Hospice and Palliative Care Advocate
by Christian Sinclair (@ctsinclair)As some of you may already now, we lost a great voice and energy in our field of palliative care and hospice yesterday, August 4th, when Kathy Brandt died at home with her wife,Kimberly Acquaviva and son, Greyson. Kathy was diagnosed with ovarian cancer in January of 2019. Kathy most recently worked on the National Consensus Project Guidelines, 4th edition, as the writer and editor, which was released in 2018. She had over 30 years experience in the aging and end-of-life issues and was helpful to many organizations as theprincipal and founder of the kb group.In addition to all that work o...
Source: Pallimed: A Hospice and Palliative Medicine Blog - August 5, 2019 Category: Palliative Care Tags: sinclair Source Type: blogs

Washington D.C. Progress in Implementing Medical Aid-in-Dying Act
Compassion & Choices today praised D.C. Health for releasing two years of reports showing it is making progress in implementing the D.C. Death with Dignity Act, despite repeated congressional attempts to repeal the law since it took effect on Feb. 18, 2017. The D.C. Death with Dignity Act allows mentally capable, terminally ill adults with six months or less to live to have the option to request a doctor’s prescription for medication they can decide to take if their end-of-life suffering becomes unbearable, so they can die peacefully in their sleep. Eight states currently allow medical aid in dying: California...
Source: blog.bioethics.net - August 3, 2019 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs