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Dieneke
A few days ago I discovered that my blog reader/friend Dieneke Ferguson had died months ago, in October. She had been diagnosed with MM in her 50s for which she had undergone many conventional treatments. When she was left with no options (but the final one!!!), many years ago, she came across my blog, got in touch with me, and began taking curcumin, which managed to stabilize her so much so that in 2018 she was interviewed by BBC Radio 4. That interview, if my memory serves me correctly, was picked up by other news agencies. Dieneke became quite well-known.
Unfortunately, she later developed ovarian cancer. The last time ...
Source: Margaret's Corner - February 9, 2021 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs
Do hair dyes increase cancer risk?
This study also had several limitations. First, participants were female nurses of mostly European descent, meaning the findings are not necessarily generalizable to men or to other racial or ethnic groups. Next, the study could not account for every single cancer risk factor (for example, exposure to pesticides and other environmental chemicals). Data were not collected on other hair grooming products beyond hair dyes, and subjects may have mistakenly reported use of permanent hair dyes when they were in fact using semi-permanent or natural dyes. Without data on actual color of hair dyes used, the authors assumed that hai...
Source: Harvard Health Blog - January 20, 2021 Category: Consumer Health News Authors: Shinjita Das, MD Tags: Cancer Skin and Hair Care Source Type: blogs
Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects."
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease
Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Quality of Epigenetic Clocks Continues to Improve
There is at present a diverse exploration of clocks that assess biological age, these clocks constructed as weighted combinations of data picked from the epigenome, transcriptome, or proteome, all of which change in characteristic ways with age. Many different clocks are at various stages of development and refinement. The goal is the production of a robust, low-cost, rapid way to assess the efficacy of potential rejuvenation therapies: if one can use a blood test ten days before and ten days after a treatment, that would be a great deal easier than having to wait and see over the course of a life span.
Unfortunate...
Source: Fight Aging! - December 16, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Aspirin and breast cancer risk: How a wonder drug may become more wonderful
Aspirin has been called a wonder drug. And it’s easy to see why.
It’s inexpensive, its side effects are well-known and generally minor. And since it was developed in the 1890s, it’s been shown to provide a number of potential benefits, such as relieving pain, bringing down a fever, and preventing heart attacks and strokes. Over the last 20 years or so, the list of aspirin’s potential benefits has been growing. And it might be about to get even longer: did you know that aspirin may lower your risk of several types of cancer?
Studies of aspirin and cancer
A number of studies suggest that aspirin can lower the risk of...
Source: Harvard Health Blog - October 23, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Breast Cancer Health Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, September 21st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pediatric Fertility Preservation for Hormone Suppression in Transgender Youth
Last week, I received an e-mail update on current research and treatment being performed at the institution where I did my residency training. One of the interesting research areas was in the discipline of pediatric fertility preservation. Pediatric patients who undergo cancer treatments often take medications which cause destruction of their testicles or ovaries, not … Continue reading "Pediatric Fertility Preservation for Hormone Suppression in Transgender Youth"
Source: blog.bioethics.net - September 1, 2020 Category: Medical Ethics Authors: Mark McQuain Tags: Health Care bioethics biotechnology human dignity reproduction syndicated Source Type: blogs
Fight Aging! Newsletter, August 10th 2020
This study aimed to characterize the role of BDNF in age-related microglial activation. Initially, we found that degrees of microglial activation were especially evident in the substantia nigra (SN) across different brain regions of aged mice. The levels of BDNF and TrkB in microglia decreased with age and negatively correlated with their activation statuses in mice during aging. Interestingly, aging-related microglial activation could be reversed by chronic, subcutaneous perfusion of BDNF. Peripheral lipopolysaccharide (LPS) injection-induced microglial activation could be reduced by local supplement of BDNF, while shTrkB...
Source: Fight Aging! - August 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 29th 2020
In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks.
Sedentary Behavior Raises the Risk of Cancer Mortality
https://www.fightaging.org/archives/2020/06/sedentary-behavior-raises-the-risk-of-cancer-mortality/
Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases cancer mortality, and does so independently of other factors. This is one of many, many reasons to maintain a re...
Source: Fight Aging! - June 28, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescence-Associated Secretory Phenotype Proteins as a Biomarker of Aging
In today's open access research, the authors report on the generation of a biomarker of aging from the study of proteins secreted by senescent cells. Low cost assays that map closely to biological age, the burden of damage, are a potentially useful tool for research and development of rejuvenation therapies. This biomarker is likely not general enough for that role; the accumulation of senescent cells with age in tissues throughout the body is just one of a number of mechanisms important in degenerative aging. It is always good to have further evidence that senescent cells are important in aging, to add to the very compell...
Source: Fight Aging! - June 26, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
New drugs approved for advanced BRCA-positive prostate cancer
Defective BRCA genes are well known for their ability to cause breast and ovarian cancers in women. But these same gene defects are also strong risk factors for aggressive prostate cancer in men. About 10% of men with metastatic prostate cancer — meaning cancer that is spreading away from the prostate — test positive for genetic mutations in BRCA genes. Fortunately, these cancers can be treated with new types of personalized therapies.
In May, the FDA approved two new drugs specifically for men with BRCA-positive metastatic prostate cancer that has stopped responding to other treatments. One of the drugs, called rucapa...
Source: Harvard Health Blog - June 15, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Prostate Knowledge Treatments HPK Source Type: blogs
Chemotherapy and hearing loss: Monitoring is essential
Treatment for cancer is a difficult time for patients and their families. While there are significant benefits of chemotherapy in treating and managing many types of cancers, some of the negative side effects may not always be so obvious. One of the potential negative effects of chemotherapy that you may not be aware of is hearing loss. Hearing loss caused by chemotherapy is generally considered a type of sudden hearing loss, so monitoring hearing before and after treatment with hearing tests is important.
How are chemotherapy and hearing loss connected?
Hearing loss as a potential side effect of chemotherapy is more likel...
Source: Harvard Health Blog - April 13, 2020 Category: Consumer Health News Authors: James Naples, MD Tags: Cancer Ear, nose, and throat Hearing Loss Source Type: blogs
Fight Aging! Newsletter, March 16th 2020
We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site.
Age-Related Epigenetic Changes that Suppress Mitochondrial Function
https://www.fightaging.org/archives/2020/03/age-related-epigenetic-changes-that-suppress-mitochondrial-function/
Today's open access research reports on two specific epigenetic changes observed in old individuals that act to reduce mitochondrial function. This joins an existing list of genes for which expression changes are known to impact mitochondrial function with age. A herd of hundreds of mitochondria are found ...
Source: Fight Aging! - March 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Novel Reprogramming Approach Applied to Generation of Cells for Retinal Regeneration
Researchers here report on the application of a novel form of cellular reprogramming that might be more useful than the present standard approach when it comes to generating patient-matched cells and tissues for regenerative medicine. They demonstrate this via the creation of vascular progenitor cells that might be used to treat some forms of retinal degeneration in which blood vessels in that tissue have atrophied.
Scientists began their experiments with a fibroblast - a connective tissue cell - taken from a person with type 1 diabetes. Reprogrammed fibroblasts function as stem cells, with the potential to give r...
Source: Fight Aging! - March 13, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
