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Fight Aging! Newsletter, June 25th 2018
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics.
Exercise versus the Hallmarks of Aging
https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/
The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I dis...
Source: Fight Aging! - June 24, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Lie of Precision Medicine
My next blog post will be entitled " The Lie of Precision Medicine "— sarcastic_f (@sarcastic_f)June 23, 2018This post will be my own personalized rant about the false promises of personalized medicine. It will not be about neurological or psychiatric diseases, the typical topics for this blog. It will be about oncology, for very personal reasons: misery, frustration, and grief. After seven months of research on immunotherapy clinical trials, I couldn ' t find a single [acceptable] one1 in either Canada or the US that would enroll my partner with stage 4 cancer. For arbitrary reasons, for financial reasons, because ...
Source: The Neurocritic - June 24, 2018 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
Fight Aging! Newsletter, June 18th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 17, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An emotional day as a doctor
My first patient of the day has metastatic pancreatic cancer. She’s had it, in fact, for two years. Getting chemo for two years. Her hair has fallen out, her pain is becoming uncontrollable and she’s been in and out of the hospital.
Her daughters came to the clinic with her. She is tearful. Her daughters pull me aside. “Tell her to focus on the positive,” they request. I wonder if there is ever a positive twist on having metastatic pancreatic cancer, but I keep my thoughts to myself. This is not about me. It’s about this patient who is living with it.
Every question I ask her gets answered by ...
Source: Kevin, M.D. - Medical Weblog - June 14, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/uzma-khan" rel="tag" > Uzma Khan, MD < /a > Tags: Physician Hospital-Based Medicine Oncology/Hematology Source Type: blogs
Increasing Pancreatic Cancer Detection Rates with Machine Learning
Most patients with pancreatic cancer receive their diagnosis when it ’s too late, as it’s often difficultto identify the tumor during its early stages. A team of researchers at Johns Hopkins University (JHU) are trying to rectify the disease ’s low detection rate by developing a deep learning algorithm that can recognize pancreatic cancer when it can still be easily removed.Karen Horton, MD, director of JHU ’s department of radiology and radiological science, and Elliot K. Fishman, MD professor and director of Diagnostic Imaging and Body CT at the university’s hospital, are spearheading The Felix Project, a mu...
Source: radRounds - June 8, 2018 Category: Radiology Authors: Julie Morse Source Type: blogs
The Not-Quite Annual ASCO Round-Up - 2018 edition
by Drew RosielleTheAmerican Society of Clinical Oncology annual meeting, besides being a feast for the pharmaceutical business news pages (google ' ASCO ' and most of the hits will be about how announcement X affected drug company Y ' s stock), is also one of the premiere platforms for publishing original palliative-oncology research. So every year I try to at least scan the abstracts to see what ' s happening, and I figure I might as well blog about it. It ' s tough to analyze abstracts, so I ' ll mostly just be summarizing ones that I think will be of interest to hospice and palliative care folks. I imagine I ' ve missed...
Source: Pallimed: A Hospice and Palliative Medicine Blog - June 6, 2018 Category: Palliative Care Tags: artificial nutrition ASCO cannabanoid code status conference reviews fatigue hpmglobal marijuana mindfulness mucositis neuropathic oncology pain race rosielle scrambler Source Type: blogs
Blood Test for Quick and Early Diagnosis of Pancreatic Cancer
Pancreatic cancer is notoriously famous for being a merciless killer, but the reality is that our current inability to diagnose it early is what makes it so intractable. Earlier diagnosis would allow therapies to be initiated before the cancer become...
Source: Medgadget - May 21, 2018 Category: Medical Devices Authors: Editors Tags: Diagnostics Genetics Pathology Source Type: blogs
‘Immigrants’ Bring Patient Engagement Energy
By MICHAEL L. MILLENSON
An Irish software expert who’d been helping companies sell on eBay walks into a room with a Slovenian inventor who’d built a world-class company in the “accelerator beam diagnostics market.” (Don’t ask.) What they share is not just foreign birth, but “immigration” to health care from other fields. Both have come to the MedCity Invest conference in Chicago seeking funding for start-ups focused on patient engagement. They’re not alone in their “immigrant” status, and their experience holds some important lessons.
Eamonn Costello, chief executive officer of patientMpower, works out ...
Source: The Health Care Blog - May 21, 2018 Category: Consumer Health News Authors: Matthew Holt Tags: Health 2.0 digital health engineer Entrepreneurs Healthcare Immigration inventor mHealth Michael Millenson patient engagement software start-ups Source Type: blogs
Implantable Device to Deliver Chemo to Pancreatic Cancer Tumors
Pancreatic cancer is difficult to fight because of the challenge of delivering chemo specifically to that one organ, sparing surrounding tissue and the rest of the body.
Advanced Chemotherapy Technologies, based in Raleigh, North Carolina, is working...
Source: Medgadget - May 16, 2018 Category: Medical Devices Authors: Editors Tags: GI Oncology Surgery Source Type: blogs
Fight Aging! Newsletter, May 14th 2018
This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition.
In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - May 13, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CAR-T Therapy Eliminates Metastatic Colorectal Cancer in Mice
In this study, the researchers tested a human-ready version of the therapy in mice. They showed that mice with human colorectal tumors treated with CAR-T therapy successfully fought the tumor cells. All of the mice studied survived without side effects for the duration of the observation period - or 75 days, compared to a 30-day average survival of mice with control treatment. In order to more closely replicate late-stage disease in humans, researchers also looked at a mouse model of colorectal cancer that developed lung metastases, a common site for metastasis in colorectal cancer patients. Mice that were treated with the...
Source: Fight Aging! - May 8, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 23rd 2018
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - April 22, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What's Been Left Out
Would You Do It Again?Over on myother blog, every Monday, I writeGood Decision/Bad Decision posts. The idea is to dissect a decision, usually financial, from various viewpoints. Nothing we do in life is truly good or bad, there are always consequences. This week, I am going to tackle something a little more personal. Should I have gone to medical school?This question is fraught with emotional pitfalls. How could it not be? From the moment I can remember, I have wanted to be a doctor. It has been with me for every breath and aspiration. Now at the age of 44, Almost twenty years into m...
Source: In My Humble Opinion - April 14, 2018 Category: Primary Care Authors: Jordan Grumet Source Type: blogs
