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Fight Aging! Newsletter, November 16th 2020
This study conclusively demonstrates the long-speculated relationship between aging, gene regulation, and somatic damage. The results open up new avenues of research with practical implications. If the same level of coordination reduction between genes is indeed a leading cause for aging phenomena, there may be a need to change course in current efforts to develop aging treatments. Using Oligodendrocyte Extracellular Vesicles to Induce Tolerance to Myelin as a Treatment for Multiple Sclerosis https://www.fightaging.org/archives/2020/11/using-oligodendrocyte-extracellular-vesicles-to-induce-tolerance-to-myelin-a...
Source: Fight Aging! - November 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Palliative care and the importance of holding space PODCAST
“Holding space means being physically, mentally, and emotionally present for someone. It means putting your focus on someone to support them as they feel their feelings. An important aspect of holding space is managing judgment while you are present. Like when you tell a patient that they have stage IV pancreatic cancer and that it […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - November 11, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Palliative Care Source Type: blogs

Medical aid in dying is not assisted suicide PODCAST
“To help the reader understand the issues better, I would like to relate some stories. A friend of mine was dying of pancreatic cancer. He had an implantable morphine pump and was on both hospice and palliative care. Still, he found that his suffering was unbearable and wanted to die sooner. Doctors told him that […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - November 9, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Palliative Care Source Type: blogs

Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro. We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Intermittent Fasting Improves Biomarkers in Metabolic Syndrome Patients
There is a blurry gray area between intermittent fasting and time restricted feeding. The study here is somewhere in that zone, as the participants did eat daily, with less fasting time between meals than would be the case for, say, alternate day fasting. Time spent hungry does appear to be influential to the outcome, but perhaps less so than overall calories consumed. Inevitably, people eat fewer calories if given less time in which to consume calories. Unsurprisingly, eating less improves metrics in people with metabolic syndrome, a condition achieved by being overweight as a result of eating too much. The point of inter...
Source: Fight Aging! - November 5, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A Conservative View of Targeting NAD+ Metabolism in Diseases of Aging
NAD+ metabolism in the context of aging and age-related disease is an area of some interest of late. NAD+ is involved in mitochondrial function, essential to cell and tissue function. The mechanisms of synthesizing and recycling NAD+ decline with age, and this might be an important contributing factor in the decline of mitochondrial function throughout the body. Certainly, the evidence in cells and animals suggests that mitochondrial function can be improved via restoration of youthful levels of NAD+. Given that the available ways of manipulating NAD+ metabolism largely involve supplementation with vitamin B3 deriva...
Source: Fight Aging! - November 5, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Microfluidic Device to Test Pancreatic Cancer Drugs
Certain varieties of pancreatic cancer exhibit multiple tumor cell subtypes that work, somewhat mysteriously, to quickly become resistant to chemotherapy agents. Researchers at Purdue University have now built a unique microfluidic device that can be...
Source: Medgadget - October 30, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Medicine Source Type: blogs

Fight Aging! Newsletter, September 14th 2020
This study is the first to provide a direct link between this inflammation and plaque development - by way of IFITM3. Scientists know that the production of IFITM3 starts in response to activation of the immune system by invading viruses and bacteria. These observations, combined with the new findings that IFITM3 directly contributes to plaque formation, suggest that viral and bacterial infections could increase the risk of Alzheimer's disease development. Indeed, researchers found that the level of IFITM3 in human brain samples correlated with levels of certain viral infections as well as with gamma-secretase activ...
Source: Fight Aging! - September 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Targeting Cellular Senescence to Heal Non-Healing Wounds
An accumulation of senescent cells takes place throughout the body with age. Cells become senescent constantly, the vast majority as a consequence of hitting the Hayflick limit on replication of somatic cells. In youth, these cells are efficiently removed, either via programmed cell death, or destroyed by the immune system. In later life, removal processes slow down, while the damaged state of tissue provokes ever more cells into becoming senescent. In older people, this imbalance leads to a state in which a few percent of all cells in tissues are senescent at any given time. This is, unfortunately, more than enough to pro...
Source: Fight Aging! - September 10, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Digital Health Makes Healthcare Globalised
Consider Atlas Biomed, the company behind the at-home microbiome test: it is based in the U.K. Some 1,900 kilometers away in Italy, Dante Labs offers direct-to-consumer whole genome sequencing kits. On the other side of the Atlantic Ocean, in the U. S., is Fitbit, which ships its fitness trackers around the world. Despite being headquartered in different countries and even in different continents, patients now have access to quality digital health services wherever they are (save for some shipping restrictions). This aspect of digital health heralds one of its lesser-explored advantages: it enables healthcare to be ...
Source: The Medical Futurist - August 18, 2020 Category: Information Technology Authors: Prans Tags: Future of Medicine Healthcare Design Healthcare Policy digital health Source Type: blogs

Fight Aging! Newsletter, August 17th 2020
In this study, we sought to elucidate the role of VRK-1 in regulation of adult life span in C. elegans. We found that overexpression of VRK-1::GFP (green fluorescent protein), which was detected in the nuclei of cells in multiple somatic tissues, including the intestine, increased life span. Conversely, genetic inhibition of vrk-1 decreased life span. We further showed that vrk-1 was essential for the increased life span of mitochondrial respiratory mutants. We demonstrated that VRK-1 was responsible for increasing the level of active and phosphorylated form of AMPK, thus promoting longevity. A Fisetin Variant, C...
Source: Fight Aging! - August 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reviewing the Mechanisms of Longevity in Long-Lived Bats
Today's open access research is a good companion piece to a recent paper that investigates biochemical differences between long-lived and short-lived bats. Bats are renowned for, firstly, an exceptional resistance to classes of virus that are fatal to other mammals, allowing bat populations to act as reservoirs for potentially dangerous pathogens, and secondly for an exceptional longevity in comparison to other mammalian species of a similar size. In mammals, species longevity tends to scale up with size, with a few notable and well-studied long-lived exceptions such as naked mole-rats, humans, and some bats. In ter...
Source: Fight Aging! - August 14, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Five Things You May Not Realize Can Affect Your Mental Health
Did you know diabetes affects your mental health? From depression to relationship problems or mood swings, too much or too little glucose (sugar) circulating in the blood can trigger behavior and thought patterns that may seem unrelated to how much insulin is released by your pancreas. Out of control glucose levels influence how you feel and make decisions, your beliefs and, yes, your attitude, a very necessary component of your overall care.  The U.S. Centers for Disease Control and Prevention (CDC) states less than half the number of people with diabetes who have depression get treated, which leads to worsening states o...
Source: World of Psychology - May 30, 2020 Category: Psychiatry & Psychology Authors: Jan McDaniel Tags: Mental Health and Wellness Comorbidities Diabetes Drug Interactions Nutrition Source Type: blogs

Weight-loss drug Belviq recalled
In February, the manufacturer of the weight-loss medication lorcaserin (Belviq, Belviq XR) voluntarily withdrew the drug from the US market at the request of the FDA. This was a result of emerging data showing that people who had taken the drug as part of a large clinical trial had an increased occurrence of cancer five years later. What were the findings about Belviq, and why did this information come to light now? Lorcaserin was approved by the FDA in 2012. As part of the approval process, the FDA reviewed a series of clinical trials that looked at its effects on weight and its safety profile, compared to a placebo. Base...
Source: Harvard Health Blog - April 9, 2020 Category: Consumer Health News Authors: Florencia Halperin, MD Tags: Diet and Weight Loss Drugs and Supplements Source Type: blogs

Fight Aging! Newsletter, March 23rd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - March 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs