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The rise of targeted therapies: the era of the patient-focused approach   
There is an urgent need for innovation in cancer treatments. Although we ’ve seen significant progress in indications for drugs treating particular diseases, cancer research data shows that 10-year survival statistics for cancers such as esophageal and lung cancer, for instance, have shown only a 10 percent increase, while pancreatic cancer has shown no significant im provement sinceRead more …The rise of targeted therapies: the era of the patient-focused approach    originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - November 12, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/m-yair-levy" rel="tag" > M. Yair Levy, MD < /a > < /span > Tags: Meds Oncology/Hematology Source Type: blogs

Food Intolerances: A Warning of Bad Things Ahead
I’ve recently discussed how the majority of food intolerances, whether to FODMAPs, histamine, nightshades, fructose, etc., are really manifestations of dysbiosis and SIBO. Here is another way to view these phenomena: Food intolerances are your body’s signal to you that serious deterioration in your health is coming. In other words, if all you do is choose to reduce or eliminate the offending food, you are still left with the massive disruption of your intestinal microbiome that caused the food intolerance in the first place, along with increased intestinal permeability and endotoxemia. So say you eliminate ferm...
Source: Wheat Belly Blog - November 1, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open microbiota prebiotic probiotic sibo small intestinal bacterial super gut undoctored wheat belly Source Type: blogs

Fight Aging! Newsletter, October 11th 2021
In conclusion, this study examined how age and the process of aging are associated with changes in the microbiome of the small intestine, using validated sampling and processing techniques. The most significant differences are higher relative abundance of the phylum Proteobacteria and decreased relative abundance of Bacteroidetes in older subjects when compared to the youngest group. The higher relative abundance of Proteobacteria appeared to affect other duodenal microbial taxa, leading to decreased microbial diversity and increased relative abundance of coliforms and of anaerobic bacteria. The small intestine is vital to...
Source: Fight Aging! - October 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, October 4th 2021
In conclusion, premature thymic involution and chronic inflammation greatly contribute to increased morbidity and mortality in CKD patients. Mechanisms are likely to be multiple and interlinked. Even when the quest to fountain of youth is a pipe dream, there are many scientific opportunities to prevent or to, at least in part, reverse CKD-related immune senescence. Further studies should precisely define most important pathways driving premature immune ageing in CKD patients and best therapeutic options to control them. Extending Life Without Extending Health: Vast Effort Directed to the Wrong Goals https://www...
Source: Fight Aging! - October 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Senolytics as a Potential Treatment for Precancerous Lesions
It is reasonable to think that intermittent treatment with senolytics can suppress cancer incidence by killing the senescent cells that are present in precancerous lesions, whether or not they are too small to be identified by present screening techniques. This should reduce the number of cells that can potentially go on to become cancerous, and also remove the contribution of senescent cell signaling to the growth and inflammatory status of the lesion. It should not be too challenging to prove this hypothesis in animal models, but prevention of cancer in the general sense is, unfortunately, a hard sell when it comes to cl...
Source: Fight Aging! - September 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Pancreatic Organoids Grown Inside Synthetic Gel
A team at MIT has developed a technique to grow organoids, both from healthy and cancerous pancreatic tissue, using a synthetic gel that predictably mimics the pancreatic extracellular environment. Compared with naturally derived materials, the synth...
Source: Medgadget - September 23, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology Source Type: blogs

A Man With Sudden Onset of Gastroparesis
By HANS DUVEFELT Leo Dufour is not a diabetic. He is in his mid 50s, a light smoker with hypertension and a known hiatal hernia. He has had occasional heartburn and has taken famotidine for a few years along with his blood pressure and cholesterol pills. Over the past few months, he started to experience a lot more heartburn, belching and bloating. Adding pantoprazole did nothing for him. I referred him to a local surgeon who did an upper endoscopy. This did not reveal much, except some retained food in his stomach. A gastric emptying study showed severe gastroparesis. The surgeon offered him a trial of metoclopra...
Source: The Health Care Blog - September 16, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Primary Care Hans Duvefelt Source Type: blogs

The 9 Trends Shaping the Future of Pharma
The drug sends a message to a caregiver after the patient swallowed it. The doctor prescribes virtual reality treatments for migraines. Do you think it is science fiction? You are mistaken. Just let me familiarize you with the top 10 trends shaping the future of pharma. And if you want to have a more in-depth analysis of the topic, read our related ebook, Technologies Shaping the Future of Pharma! Technologies Shaping the Future of Pharma We designed this e-book to serve as a collection of relevant examples, best practices and exciting ideas that can help any pha...
Source: The Medical Futurist - August 26, 2021 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine Future of Pharma 3d printing artificial intelligence augmented reality digital health Innovation nanotechnology Personalized medicine pharmacology virtual reality VR gc4 pharmacies pharmacogenetics Source Type: blogs

The 10 Trends Shaping the Future of Pharma
The drug sends a message to a caregiver after the patient swallowed it. The doctor prescribes virtual reality treatments for migraines. Do you think it is science fiction? You are mistaken. The pharma industry has taken a big swung into digital transformation. All participants invest in digital health topics. But as with all trending issues, and there is a lot of fuss that is hard to see through. As the medical community increasingly acknowledges the importance of digital health, the cultural shift we so often talk about is still a way to go. To change that, the first step is always getting to know what’s coming. ...
Source: The Medical Futurist - August 26, 2021 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine Future of Pharma 3d printing artificial intelligence augmented reality digital health Innovation nanotechnology Personalized medicine pharmacology virtual reality VR gc4 pharmacies pharmacogenetics Source Type: blogs

Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns. First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Strength Training and Aerobic Exercise Reduce Cancer Mortality
Researchers here note that undertaking strength training and aerobic exercise acts to reduce mortality due to cancer, to a similar degree as these activities are known to reduce all cause mortality in later life. The mechanisms involved are likely diverse, but it is worth noting that (a) muscle tissue is metabolically active in beneficial ways, such that more muscle is better than less muscle, (b) better immune function is linked to exercise, and immune surveillance is critical to cancer prevention, and (c) exercise helps to reduce chronic inflammation, where chronic inflammation helps to drive the establishment and develo...
Source: Fight Aging! - August 17, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A case for changing the way we talk about obesity
You are finger. No, I have fingers. You are leg. No, I have legs. You are pancreas. No, I have a pancreas. You are fat. Hmm … Now let’s try this with disease processes: You are diabetes. No, I have diabetes. You are cancer. No, I have cancer. You are anorexia. No, I have anorexia.Read more …A case for changing the way we talk about obesity originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - July 16, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/jill-becker" rel="tag" > Jill Becker, MD < /a > < /span > Tags: Conditions Obesity Source Type: blogs

Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Introducing Developmental Signaling into Adults in Order to Produce Regeneration
Is it possible to safely introduce developmental signaling characteristic of the developing embryo and fetus into an aged adult in order to spur greater regeneration of tissues? The past decades of work on embryonic stem cell therapies and induced pluripotent stem cell therapies, and the slow investigation of how most of these therapies produce their benefits via cell signaling, suggest that this goal is in principle possible. Similarly, research into species capable of proficient regeneration, such as salamanders and zebrafish, suggests broad similarities between the biochemistry of organ development and the biochemistry ...
Source: Fight Aging! - June 17, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Health effects of partial hydrogenation of vegetable oils
Partially hydrogenated vegetable oils contain trans fatty acids which are different from the natural fatty acids in vegetable oils and animal fat [1]. Fatty acids in partially hydrogenated vegetable oils are 14 cis and trans isomers of octadecenoic and octadecadienoic acids that are formed during hydrogenation. Trans fatty acids cause inflammation and calcification of arterial walls. They also inhibit cyclooxygenase needed for conversion of arachidonic acid to prostacyclin, a compound beneficial for the vascular tree. There are reformulations of hydrogenated fat containing the essential fatty acid linoleic acid which get...
Source: Cardiophile MD - April 25, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs