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Total 424 results found since Jan 2013.

Raman-Based Urine Sensor Detects Cancer Metabolites
Researchers at the Korea Institute of Materials Science (KIMS) creaetd a Raman-spectroscopy-based urine test that can detect metabolic compounds that are produced by pancreatic and prostate cancers, potentially allowing for rapid and convenient cance...
Source: Medgadget - February 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Oncology Pathology Source Type: blogs

The regret of leaving an old friend behind
I once knew a lady who eventually died from pancreatic cancer. She was in her early seventies at the time. Her name was Marilyn, and I went to grade school with her son Tom, so we had known each other for a long time. I was in my early thirties when the events happened. Marilyn’s Read more… The regret of leaving an old friend behind originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - February 19, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes. Communication Between Blood and Brain in Aging and Rejuvenation https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/ As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inter...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

6 Potential Medical Use Cases for ChatGPT
The internet is buzzing with news on ChatGPT, and how everyone uses it to write love poems, homework, summaries of articles, or python codes. ChatGPT is the latest generation of a large language model, designed to generate text upon user input. There is a lot of discussion regarding its potential use in medicine, so let’s see, what you can expect from it and what you should not use it for – at least in its current form. Unlike the text-to-image tool Midjourney, which we introduced earlier, and which is a GAN (generative adversarial network, explained here) algorithm, ChatGPT is a different kind of algorithm R...
Source: The Medical Futurist - December 19, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI chatbot AI text generator AI in heaalthcare ChatGPT Conversationlal_AI Source Type: blogs

Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting. Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Senescent Cells as a Cancer Vaccine
Researchers here note the discovery that vaccinating mice with senescent cancer cells ensures that the immune system will more aggressively attack a later introduction of cancerous cells. Since we know that most cancer therapies induce senescence in cancerous cells to a fair degree, one has to think that the effectiveness of this approach will diminish as a cancer progresses to form a solid tumor and co-opts the immune system in various ways. Still, it sounds as though it could be a potentially useful after, for example, surgical resection of a tumor, to help reduce the odds that the cancer will reoccur. Scientis...
Source: Fight Aging! - November 9, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Weekly Overseas Health IT Links – 22nd October, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://mhealthintelligence.com/news/partnership-to-add-virtual-primary-care-feature-to-smart-tvsPartnership to Add Virtual Primary Care Feature to Smart TVsTelehealth provider HealthTap has partnered with Samsung to add a virtual healthcare feature to the tech giant ' s Smart TVs to expand access to primary care.ByMark MelchionnaOctober 14, 2022 - Aiming to ...
Source: Australian Health Information Technology - October 22, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

NALCN is a Regulator of Cancer Metastasis
If cancers were not metastatic, did not spread themselves throughout the body, then cancer would be a much less dangerous medical condition. Tumors would be largely amenable to surgical removal, and long-term control and suppression of cancer, even at late stages, would be a feasible goal. Thus research into the biochemistry of metastasis is important. If commonalities exist in the regulation of metastasis across many cancers, interventions to suppress metastasis could lead to a sizable reduction in cancer mortality. The research here shows that cancers may hijack an existing regulatory mechanism controlling cell motility ...
Source: Fight Aging! - October 6, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, September 5th 2022
Conclusion Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome. The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial dive...
Source: Fight Aging! - September 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 15th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 14, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Weekly Overseas Health IT Links – 13th August 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://ehrintelligence.com/news/va-appoints-functional-champion-for-ehr-modernization-programVA Appoints Functional Champion for EHR Modernization ProgramThe new functional champion appointment will assist the VA EHR Modernization program as it struggles with implementation delays and cost overruns, the VA stated.BySarai RodriguezAugust 05, 2022 - The Depart...
Source: Australian Health Information Technology - August 13, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Cellular Senesence, a Key Target in the Treatment of Aging
Scores of animal studies provide compelling evidence for cellular senescence to contribute meaningfully to many age-related conditions, and yet more such studies demonstrate rapid and sizable rejuvenation via targeted removal of senescent cells in old animals using varieties of senolytic therapy. Senescent cells are created constantly in the body, the result of cells reaching the Hayflick limit on replication, tissue injury, or encountering cellular damage or toxicity. When an individual is young, these newly senescent cells are near all removed by a combination of programmed cell death and the actions of the immune system...
Source: Fight Aging! - August 10, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

mRNA Vaccines: From Tackling Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.  What is mRNA? In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs