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Evidence summary on aspirin for primary prevention of cardiovascular disease and colon cancer
Source: Notes from Dr. RW - July 14, 2017 Category: Internal Medicine Tags: cardiovascular gastroenterology pharmacology Source Type: blogs

Medial EarlySign: machine learning for population health (podcast)
https://healthbb.files.wordpress.com/2017/07/hbdew057-david-e-williams-interviews-medials-tomer-amit.mp3 Medial EarlySign analyzes standard EHR data to identify individuals at high risk for disease. The company’s first solution, ColonFlag uses longitudinal blood test data to identify patients who are at high risk for colorectal cancer. I spoke recently with Medial executive Tomer Amit, who filled me in on the company’s approach and explained why the company has been named a Cool Vendor in AI by Gartner. (0:15) What unmet need are you serving? (1:05) You talk about using data that’s already available. Wha...
Source: Health Business Blog - July 7, 2017 Category: Health Management Authors: dewe67 Tags: Entrepreneurs International Technology Israel machine learning Source Type: blogs

Hand-Held Probe Can Detect Cancer Cells in Real-Time During Surgery
Scientists in Montreal, Canada have perfected a hand-held Raman spectroscopy probe that surgeons can use to distinguish between cancer cells and normal tissue. Raman spectroscopy is a technique that involves shining light on a material and analyzing ...
Source: Medgadget - June 29, 2017 Category: Medical Devices Authors: Conn Hastings Tags: Neurosurgery Ob/Gyn Pathology Thoracic Surgery Urology Source Type: blogs

Fight Aging! Newsletter, June 19th 2017
This study is the first to show that downregulation of PAPP-A expression in adult mice can significantly extend life span. Importantly, this beneficial longevity phenotype is distinct from the dwarfism of long-lived PAPP-A KO, Ames dwarf, Snell dwarf and growth hormone receptor (GHR) KO mice with germ-line mutations. Thus, downregulation of PAPP-A expression joins other treatment regimens, such as resveratrol, rapamycin and dietary restriction, which can extend life span when started in mice as adults. In a recent study, inducible knockdown of the GHR in young adult female mice increased maximal, but not median, lif...
Source: Fight Aging! - June 18, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How important is Vitamin D?
FACT: A vitamin D deficiency may result in as much as a 50 percent increased potential for diabetes. FACT: A vitamin D deficiency puts you at a higher risk for cancer, especially breast, prostate, colon, ovarian, and melanoma. VITAMIN D DEFICIENCY is a widespread phenomenon with significant implications for health. In modern society vitamin D deficiency is the rule, rather than the exception. While we can blame more severe cases of deficiency on grains, it also commonly occurs independent of grain consumption. The restoration of vitamin D levels is second only to grain elimination when considering the most powerful healthy...
Source: Wheat Belly Blog - June 13, 2017 Category: Cardiology Authors: Dr. Davis Tags: Cancer Depression Diabetes News & Updates Undoctored Vitamin D Weight loss Source Type: blogs

Nanoparticles Feature Two Mechanisms to Boost Effectiveness of Immunotherapy to Fight Cancer
Image via ACS Nano Immunotherapy techniques for fighting cancer generally fall into two categories: preventing tumor cells from evading the immune system’s T cells and summoning T cells to attack the tumors. Now scientists at Johns Hopkins Uni...
Source: Medgadget - June 12, 2017 Category: Medical Devices Authors: Editors Tags: Nanomedicine Oncology Source Type: blogs

Fight Aging! Newsletter, June 12th 2017
In this study, we focused on two pathways of cardiomyocytes or heart cells: the Hippo pathway, which is involved in stopping renewal of adult cardiomyocytes, and the dystrophin glycoprotein complex (DGC) pathway, essential for cardiomyocyte normal functions." Previous work had hinted that components of the DGC pathway may somehow interact with members of the Hippo pathway. The researchers genetically engineered mice to lack genes involved in one or both pathways, and then determined the ability of the heart to repair an injury. These studies showed for the first time that dystroglycan 1, a component of the DGC pathw...
Source: Fight Aging! - June 11, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reviewing What is Known of PTEN and its Longevity Effects
The PTEN gene shows up in a number of places in aging research, and today's paper is a review of what is known of its relevance to the field. To pick a few items, PTEN appears to be involved in some of the processes and pathways that control nutrient sensing, and is thus of interest to researchers attempting to recreate the beneficial effects of calorie restriction via pharmaceuticals. It is also involved in regeneration and cancer as a governor that prevents excessive cell growth. In this context, PTEN suppression has been shown to enhance nerve regrowth in mice, but of course there are other, adverse consequences to turn...
Source: Fight Aging! - June 6, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Deletion of Gene Enhancer DNA Improves Cancer Resistance in Mice with No Apparent Loss of Normal Tissue Function
The path to effective control of cancer involves finding common mechanisms that target many different types of cancer, departing from the present approach of one costly project for every subtype of cancer. Here, researchers undertake a novel approach to the challenge, finding a sizable region of the genome that can be deleted in mice with no apparent loss of normal function. The deletion improves cancer resistance to a degree that makes suppression of the contents of this region of the genome worth pursuing as the basis for therapies that might control many types of cancer. Our cells each contain close to 20,000 g...
Source: Fight Aging! - June 6, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

An Interview with Orthopaedic Oncologist Dr. Vincent Ng
Dr. Vincent Ng is an orthopaedic oncologist with the University of Maryland Greenebaum Comprehensive Cancer Center and an Assistant Professor or Orthopaedics with the University of Maryland School of Medicine.  Dr. Ng specializes in treating bone cancer and soft tissue sarcoma.  Below he answers common questions about orthopaedic oncology. What is an orthopaedic oncologist? How do they differ from surgical oncologists? “An orthopaedic oncologist specializes in bone and soft tissue tumors.  I treat any adult or pediatric patient with any bone or soft tissue tumor/lesion/mass, whether benign or malignant, whether it is...
Source: Life in a Medical Center - June 2, 2017 Category: Universities & Medical Training Authors: UMMC Tags: Cancer Doctors bone cancer oncology orthopedics Source Type: blogs

Top Companies in Genomics
From portable genome sequencers until genetic tests revealing distant relations with Thomas Jefferson, genomics represents a fascinatingly innovative area of healthcare. As the price of genome sequencing has been in free fall for years, the start-up scene is bursting from transformative power. Let’s look at some of the most amazing ventures in genomics! The amazing journey of genome sequencing Genome sequencing has been on an amazing scientific as well as economic journey for the last three decades. The Human Genome Project began in 1990 with the aim of mapping the whole structure of the human genome and sequencing it. ...
Source: The Medical Futurist - May 30, 2017 Category: Information Technology Authors: nora Tags: Genomics Personalized Medicine AI artificial intelligence bioinformatics cancer DNA dna testing DTC gc3 genetic disorders genetics genome sequencing personal genomics precision medicine Source Type: blogs

A Health Plan CEO Daydreams
By MICHEL ACCAD, MD Jim was at his desk, looking weary. The last few weeks had been brutal.  Despite working twelve-hour days, he felt that he had little to show for it.  His annual board meeting was to take place the next day, and he expected it to be tense. With a replacement bill for the ACA about to be voted on, and with Trump in the White House, the situation seemed particularly precarious.  The board members had asked him to present a contingency plan, in case things in DC didn’t go well. As CEO of a major health insurance company, Jim was well aware that business as usual had become unsustainable in his l...
Source: The Health Care Blog - May 4, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized AHCA health reform MICHEL ACCAD repeal and replace Source Type: blogs

More young people are getting colorectal cancer. What do we do?
After years of declining rates of colorectal cancer (CRC), a study from the American Cancer Society raises the specter that not all is going as well as we would have hoped, especially among younger folks born since 1990. And that raises the question of what the future holds for this frequently preventable form of cancer, including a possible reexamination of when it is appropriate to start CRC screening for people at average risk of developing the disease. The research, published in the Journal of the National Cancer Institute looked at the rates of colon and rectal cancer diagnoses from 1974 through 2013 in several parts ...
Source: Kevin, M.D. - Medical Weblog - May 4, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/j-leonard-lichtenfeld" rel="tag" > J. Leonard Lichtenfeld, MD < /a > Tags: Conditions Cancer Source Type: blogs

Health Reform Must End the Harms of Prior Authorizations
By CRAIG BLINDERMAN, MD As the White House continues to push for a revised Republican proposal to replace the Affordable Care Act (ACA), one thing is for certain, many of the sickest Americans will continue to suffer as they are denied medications and other treatments under current health insurance strategies to save costs. Both the ACA, and the recently proposed MacArthur Amendment, do not address a well-established practice of health insurers’ use of restrictive prior authorization requirements to deny or delay coverage of medications and treatments to seriously ill patients. In my own practice caring for cancer patien...
Source: The Health Care Blog - May 3, 2017 Category: Consumer Health News Authors: John Irvine Tags: Repeal Replace Uncategorized ACA Cancer Insurers MacArthur Amendment Prior Authorization Source Type: blogs