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Fight Aging! Newsletter, November 4th 2019
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice. Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - November 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Evidence for Human Cell Division Rates to Decrease with Age
We humans exhibit a peak cancer incidence in old age, around the early 80s, after which cancer rates decline from that peak. If aging is the continual accumulation of damage, then why do we observe this pattern of cancer incidence with age rather than a continual increase over time? It does not occur in mice, after all. Researchers here provide evidence for the explanation to involve reduced rates of cell division in later life, which may be one of many evolutionary adaptations connected to the unusual longevity of our species when compared with other similarly sized mammals, and particularly other primates. If there is le...
Source: Fight Aging! - October 29, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

MKSAP: 65-year-old man interested in colorectal cancer screening
Test your medicine knowledge with the  MKSAP challenge, in partnership with the American College of Physicians. A 65-year-old man is evaluated during a visit to establish care. He is interested in colorectal cancer screening; however, he adamantly refuses to undergo colon preparation, and he does not want to modify his diet for screen ing. He has never undergone […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - October 19, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs

Becoming Overweight Raises the Risk of Many Cancers
In conclusion, adult weight gain was associated with increased risk of several major cancers. The degree, timing, and duration of overweight and obesity also seemed to be important. Preventing weight gain may reduce the cancer risk. Link: https://doi.org/10.1093/ije/dyz188
Source: Fight Aging! - October 16, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Ethicon ’s New ECHELON CIRCULAR Powered Stapler
Ethicon, a part of J&J, just unveiled the ECHELON CIRCULAR, which the company touts as the first powered circular stapler specifically designed for colorectal, gastric, and thoracic procedures. The device features so-called “Gripping...
Source: Medgadget - September 24, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: GI Surgery Thoracic Surgery Source Type: blogs

Gold Nanoclusters Power a Simple Cancer Urine Test
Researchers at Imperial College London and MIT have developed a simple cancer urine test based on injected gold nano-clusters which enter the urine only in the presence of cancer. So far, the researchers have used the test to detect colon cancer in m...
Source: Medgadget - September 4, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Nanomedicine Oncology Pathology Source Type: blogs

The costly decision of delaying surgery
It was a common enough reason for someone to have a CT scan. The order read, “Abdominal pain, colon cancer resected in January.” It was now March, only two months post-surgery. Yet the patient’s CT scan showed a number of large masses in the liver, consistent with metastatic cancer. I compared the current study to […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - August 29, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/cullen-ruff" rel="tag" > Cullen Ruff, MD < /a > < /span > Tags: Conditions Oncology/Hematology Radiology Source Type: blogs

Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Everyone Is Having the Wrong Healthcare Debate
By STEVEN MERAHN, MD In 1807, in an effort to spite the British and French for shipping interference (and forced recruitment of American citizens into military service), the United States Congress passed an Embargo Act, effectively shutting down trade with these two countries. Britain and France quickly found other trading partners; the US, then limited in our capacity to sell products outside our borders, was left with a devastated economy and a gaping hole in our face. It took only weeks before Congress passed a loophole; they repealed the act within 15 months of its passing. It was a great lesson in unintended co...
Source: The Health Care Blog - August 16, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Politics Uncategorized Health care debate Health Care Reform Steven Merahn universal healthcare Source Type: blogs

Senescent Cells Increase Risk of Colon Cancer via Secretion of GDF15
In this study, we provide both correlative and functional evidence that senescent fibroblasts and an essential SASP factor, GDF15, induce physiological and molecular changes that promote the adenoma-carcinoma initiation and progression sequence in the colon. We assessed the role of senescence and the SASP in CRC formation. Using primary human colon tissue, we found an accumulation of senescent fibroblasts in normal tissues from individuals with advanced adenomas or carcinomas in comparison with individuals with no polyps or CRC. In in vitro and ex vivo model systems, we induced senescence using oxidative stress in c...
Source: Fight Aging! - August 16, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Targeted Editing of Gut Microbe Populates Reduces Intestinal Cancer Incidence
The gut microbiome is influential on the progression of health, perhaps to a similar degree as regular moderate exercise. Age-related changes in these microbial populations can promote chronic inflammation and tissue dysfunction, though the direction of causation is still up for debate when it comes to many of the details of the relationship between tissue and immune issues in the intestine and an altered gut microbiome. Nonetheless, less desirable microbes undertake activities that can raise the risk of cancer resulting from inflammation of the intestines, occurring in conditions such as inflammatory bowel disease. Resear...
Source: Fight Aging! - August 12, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

What should you do if your blood pressure medication has been recalled?
Over the past several months, you may have heard that the FDA has recalled certain lots of angiotensin II receptor blocker (ARB) medications due to the presence of impurities. These contaminants — nitrosamine impurities — may occur as a byproduct of the manufacturing process. They include N-Nitrosodiethylamine (NDEA) and N-Nitrosodimethylamine (NDMA), which can potentially cause cancer. These substances are found in the environment as well in meats, dairy products, and water, but their presence in medications is not acceptable. Therefore, the FDA sets acceptable safety limits on the presence of these impurities in drug...
Source: Harvard Health Blog - August 5, 2019 Category: Consumer Health News Authors: James Yeh, MD, MPH Tags: Drugs and Supplements Health Hypertension and Stroke Source Type: blogs

A 60-something who has non-specific generalized malaise and is ill appearing.
An anonymous paramedic sent this.A 60-something with past history only of colon cancer called 911 for non-specific generalized malaise.The medics state that he was ill appearing.They recorded an ECG:What do you think?This is extremely wide, and even if it is VT, it is so wide that there must be hyperkalemia or a severe Na channel blocking overdose.  The patient was not on a sodium channel blocker.The paramedic knew instantly what it was (he credits his regular reading of this blog!)The patient was only a couple blocks from the hospital, so there was no time for treatment before arrival.K was 8.9 mEq/L.Etiology was a c...
Source: Dr. Smith's ECG Blog - July 29, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs

When colon cancer is diagnosed, it ’s also a difficult day for the gastroenterologist
Exercising good judgment can mean the difference between life or death. Life can be unforgiving of the choices we make. As we all know, many life events are beyond our control and understanding. But, there is much we can do to shape our paths to a brighter destination. Consider some of the choices listed below […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - July 15, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/michael-kirsch" rel="tag" > Michael Kirsch, MD < /a > < /span > Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs

Into The Future of Gastroenterology With Digestibles And Microbiome Testing
Gluten? Lactose? Stomach pain? Digestive troubles? Way too many people suffer from gastrointestinal issues, and much less are aware of the digital technologies that can come to their aid. Did you know that digestibles could successfully replace the dreaded colonoscopy? Or have you heard about microbiome testing? What about the swarm of health apps supporting dietary restrictions? We took a deep breath and jumped into the universe of digital technologies just to bring you as much information about the future of gastroenterology as possible. Will you jump after us? IBS, colorectal cancer, and other animals Referring to...
Source: The Medical Futurist - July 4, 2019 Category: Information Technology Authors: nora Tags: Future of Medicine Genomics Health Sensors & Trackers diet dieting digestibles digestion digital health gastro gastroenterologist gastroenterology gastrointestinal gluten gut Innovation lactose microbiome stomach techno Source Type: blogs