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Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Ruth Bader Ginsburg and Chadwick Boseman: a tale of two cancers in America PODCAST
“Separated by less than a month (Boseman on August 28th and Ginsburg on September 18th) and both due to gastrointestinal cancers (Boseman had colon cancer and Ginsburg had pancreatic cancer), the situations of Ginsburg ’s and Boseman’s deaths is emblematic of the racial disparity in American health outcomes. Boseman was African American/Black and was diagnosed with […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - February 27, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Oncology/Hematology Source Type: blogs
Are early detection and treatment always best?
Throughout my medical career, I’ve heard statements like these:
Early detection offers the best chance of cure.
If you wait for symptoms, you’ve waited too long.
Knowledge is power, and the sooner you have the information, the better.
Over time, I’ve realized they are often untrue. Many health conditions go away on their own. In such cases, early testing may amount to wasted effort, time, and medical cost. Some testing is invasive and has a significant risk of complications. And minor abnormalities may lead to more testing. There’s also the anxiety of waiting for results, or learning you have an abnormality of unce...
Source: Harvard Health Blog - January 28, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Back Pain Heart Health Managing your health care Prevention Screening Tests and procedures Source Type: blogs
Fight Aging! Newsletter, January 18th 2021
In this study, Desferal, deferoxamine mesylate for injection, which is approved for the treatment of acute iron intoxication and chronic iron overload, was used to explore the beneficial effects on preventing aging-induced bone loss and mitigating dysfunction of aged BMSCs. High-dose Desferal significantly prevented bone loss in aged rats. Compared with controls, the ex vivo experiments showed that short-term Desferal administration could promote the potential of BMSC growth and improve the rebalance of osteogenic and adipogenic differentiation, as well as rejuvenate senescent BMSCs and revise the expression of stemness/se...
Source: Fight Aging! - January 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why Won ’t the Doctor Do More Tests on Older Parent?
Photo Credit Unsplash
Dear Carol: My mom is 78 and she’s thrilled because her doctor told her that since she’s over 75, she’s done with taking colonoscopies and “a bunch of other tests.” I was alarmed, but she said that there’s not a lot of good to be gotten from the tests at her age, and there are risks in having them. Mom is healthy and I want to keep her that way. What if she develops colon cancer? Granted, she has no sign of any problem with her test last year, but the possibility still worries me. Is this policy just to save the health insurance companies money or is this ageism because older people ...
Source: Minding Our Elders - January 17, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Responding to Misinformation
By John Halamka and Paul CerratoThe singer/songwriter Paul Simon once penned the lyrics: A man hears what he wants to hear and disregards the rest (The Boxer). If that ’s the case, how do we respond to misinformation that contradicts the data/evidence guiding development of treatment and cures? If the only audience willing to read such articles are already critical thinkers, perhaps we are just preaching to the choir. And if by chance, a person who believes in controversial ideas does read articles based on real world evidence, will they consider them a one-sided discussion by the “medical-industrial es...
Source: Life as a Healthcare CIO - January 14, 2021 Category: Information Technology Source Type: blogs
Can I take something to prevent colorectal cancer?
Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. There is compelling evidence that screening to detect CRC early to find and remove precancerous polyps can reduce CRC mortality. However, screening has associated harms, including procedural complications, and inherent limitations. For example, colonoscopy, the most common screening tool in the US, is less effective in preventing cancers of the right, or ascending side, of the colon compared with cancers of the left, or descending, side of the colon.
Moreover, only 60% of US adults recommended for screening actually follow through. Ev...
Source: Harvard Health Blog - January 13, 2021 Category: Consumer Health News Authors: Andrew Chan, MD, MPH Tags: Cancer Prevention Screening Source Type: blogs
What does colon cancer screening have to do with self-driving cars? PODCAST
“We can clearly see that exponential technologies are disrupting cars and phones. So why wouldn ’t these technologies find their way into health care and gastroenterology? What do stool tests have to do with self-driving cars? We’ll soon find out. But let’s first go back to the discussion we had earlier on the shift to digital. […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - December 17, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Gastroenterology Oncology/Hematology Source Type: blogs
CRAZY AMERICA: Health Insurance Covers Testing When You Are Well But Not When You Are Sick
By HANS DUVEFELT
Insurance is the wrong word for what we have here. Our private health insurance system’s prioritization of sometimes frivolous screenings but non-coverage for common illnesses and emergencies is a travesty and an insult to typical American middle class families.
State Medicaid insurance for the underemployed has minimal copays of just a few dollars for doctor visits and medications. From my vantage point as a physician, it is the best insurance a patient can have. They cover almost everything and it is clear to me how to apply for exceptions or follow their step care requirements. I cannot...
Source: The Health Care Blog - December 9, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Source Type: blogs
Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a po...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aspirin and breast cancer risk: How a wonder drug may become more wonderful
Aspirin has been called a wonder drug. And it’s easy to see why.
It’s inexpensive, its side effects are well-known and generally minor. And since it was developed in the 1890s, it’s been shown to provide a number of potential benefits, such as relieving pain, bringing down a fever, and preventing heart attacks and strokes. Over the last 20 years or so, the list of aspirin’s potential benefits has been growing. And it might be about to get even longer: did you know that aspirin may lower your risk of several types of cancer?
Studies of aspirin and cancer
A number of studies suggest that aspirin can lower the risk of...
Source: Harvard Health Blog - October 23, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Breast Cancer Health Source Type: blogs
Robotic Probe for Semi-Autonomous Colonoscopies
Researchers at the University of Leeds in the UK have developed a robotic system that can assist a physician or nurse to perform a colonoscopy. The system uses magnets to guide a probe through the body, and its developers claim that the approach is e...
Source: Medgadget - October 13, 2020 Category: Medical Devices Authors: Conn Hastings Tags: GI Pathology Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Proposed guidelines likely to identify more early lung cancers
Lung cancer is the second most prevalent cancer in the US, and the deadliest cancer killer. In 2020, an estimated 135,720 people will die from the disease — more than breast, colon, and prostate cancers combined.
I’ll never forget meeting new, advanced-stage lung cancer patients who ask if their diagnosis could have somehow been made earlier, when treatment would have been more likely to succeed. In 2009, when I began practicing thoracic oncology, there were no approved screening tests for lung cancer.
A brief history of lung cancer screening
Hope for early detection and death prevention came in 2011 with the publicati...
Source: Harvard Health Blog - September 9, 2020 Category: Consumer Health News Authors: Inga Lennes, MD, MPH, MBA Tags: Cancer Lung disease Screening Source Type: blogs
Fight Aging! Newsletter, September 7th 2020
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - September 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
