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Ten reasons to NEVER eat gluten-free processed foods
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It saddens me: As popular as the Wheat Belly books and lifestyle have been, there are still millions of people who say things like “Oh, that Wheat Belly thing is just about being gluten-free.” They couldn’t be more wrong and have clearly not read any of the books.
Yes, you can be gluten-free and consume foods that naturally have no gluten, gliadin, wheat germ agglutinin, amylopectin A, phytates, and the rest of the toxic components contained in wheat and related grains. You can eat apples, bacon, eggs, and salmon that are naturally gluten-free. You can drink water or tea that is gluten-free. No problems...
Source: Wheat Belly Blog - February 1, 2019 Category: Cardiology Authors: Dr. Davis Tags: News & Updates gluten gluten-free grain-free grains wheat belly Source Type: blogs
Fight Aging! Newsletter, January 21st 2019
In this study, scientists screened cells from old animals to identify any RBPs that change upon aging. The screening showed that one particular protein, Pumilio2 (PUM2), was highly induced in old animals. PUM2 binds mRNA molecules containing specific recognition sites. Upon its binding, PUM2 represses the translation of the target mRNAs into proteins.
Using a systems genetics approach, the researchers then identified a new mRNA target that PUM2 binds. The mRNA encodes for a protein called Mitochondrial Fission Factor (MFF), and is a pivotal regulator of mitochondrial fission - a process by which mitochondria break u...
Source: Fight Aging! - January 20, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 14th 2019
In conclusion, reduction of LDL-C to less than 50 mg/dl seems safe and provides greater CV benefits compared with higher levels. Data for achieved LDL-C lower than 20-25 mg/dl is limited, although findings from the above mentioned studies are encouraging. However, further evaluation is needed for future studies and post-hoc analyses.
Wary of the Beautiful Fairy Tale of Near Term Rejuvenation
https://www.fightaging.org/archives/2019/01/wary-of-the-beautiful-fairy-tale-of-near-term-rejuvenation/
One might compare this interview with researcher Leonid Peshkin to last year's discussion with Vadim Gladyshev. ...
Source: Fight Aging! - January 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is it Safe to Greatly Reduce LDL Cholesterol, Far Below Normal Levels?
In conclusion, reduction of LDL-C to less than 50 mg/dl seems safe and provides greater CV benefits compared with higher levels. Data for achieved LDL-C lower than 20-25 mg/dl is limited, although findings from the above mentioned studies are encouraging. However, further evaluation is needed for future studies and post-hoc analyses.
Source: Fight Aging! - January 9, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Heart disease and breast cancer: Can women cut risk for both?
Very often I encounter women who are far more worried about breast cancer than they are about heart disease. But women have a greater risk of dying from heart disease than from all cancers combined. This is true for women of all races and ethnicities. Yet only about 50% of women realize that they are at greater risk from heart disease than from anything else.
Currently in the US, three million women are living with breast cancer, which causes one in 31 deaths. Almost 50 million women have cardiovascular disease, which encompasses heart disease and strokes and causes one in three deaths.
Here’s what’s really interestin...
Source: Harvard Health Blog - January 8, 2019 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Breast Cancer Exercise and Fitness Health Healthy Eating Heart Health Women's Health Source Type: blogs
Long-term statin use protects against prostate cancer death
Statins and other drugs that lessen cardiovascular disease risk by lowering blood lipids rank among the world’s most prescribed medications. And for the men who take them, accumulating evidence has for years pointed to another added benefit: a lower risk of developing prostate cancer.
Now researchers are reporting that long-term statin use (more than 10 years) can also reduce the odds of a prostate cancer death. The new findings come from a study led by Alison Mondul, a cancer epidemiologist at the University of Michigan School of Public Health.
Mondul says that most men develop slow-growing, indolent prostate cancers th...
Source: Harvard Health Blog - January 7, 2019 Category: Consumer Health News Authors: Charlie Schmidt Tags: Living With Prostate Cancer Prostate Knowledge HPK Source Type: blogs
Fight Aging! Newsletter, January 7th 2019
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup.
This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
Source: Fight Aging! - January 6, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at the Rejuvenation Research and Advocacy of 2018
Discussion of Mitochondrial Hormesis as an Approach to Slow Aging
Cornelis (Cees) Wortel, Ichor Therapeutics Chief Medical Officer, on Rejuvenation Research and Its Engagement with the Established Regulatory System
An Interview with a Programmed Aging Theorist
An Interview with Reason at the Life Extension Advocacy Foundation
An Interview on Mitochondrial Damage and Dysfunction in Aging
An Interview with Vadim Gladyshev on Research into the Causes of Aging
An Interview with Jim Mellon, and Update on Juvenescence
A Lengthy Interview with Aubrey de Grey of the SENS Research Foundation
An Interview with Peter de Keize...
Source: Fight Aging! - December 31, 2018 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, December 24th 2018
In conclusion, we found a gradient of increasing blood pressure with higher levels of BMI. The fact that this gradient is present even in the fully adjusted analyses suggests that BMI may cause a direct effect on blood pressure, independent of other clinical risk factors.
PRRX1 as a Possible Point of Control for Remyelination
https://www.fightaging.org/archives/2018/12/prrx1-as-a-possible-point-of-control-for-remyelination/
Researchers here outline what is possibly a new point of intervention in the processes that maintain the myelin sheath that wraps nerves. This sheath is vital to the correct operatio...
Source: Fight Aging! - December 23, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
LetsGetChecked Provides Easy At-Home Lab Testing and Consultations
At-home lab tests are growing in popularity. While many companies focus on specific tests, such as genetic testing or specific screenings, LetsGetChecked, a company with offices in New York, Dublin, and Toronto, hopes to be a central hub that allows...
Source: Medgadget - December 17, 2018 Category: Medical Devices Authors: Cici Zhou Tags: Diagnostics Exclusive Medicine Pathology Source Type: blogs
Fight Aging! Newsletter, December 17th 2018
In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker expression and reduction of M2 marker expression were observed in TNF-α challenged microglia. Upregulation of autophagy via serum deprivation or pharmacologic activators (rapamycin and resveratrol) promoted microglia polarization toward M2 phenotype, as evidenced by suppressed M1 and elevated M2 gene expression, while inhibition of autophagy with 3-MA or Atg5 siRNA consistently aggravated the M1 polarization induced by TNF-α.
Moreover, Atg5 knockdown alone was sufficient to trigger...
Source: Fight Aging! - December 16, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 3rd 2018
This article, however, is more of a commentary on high level strategy and the effects of regulation, coupled with a desire to forge ahead rather than hold back in the matter of treating aging, thus I concur with much more of what is said than is usually the case.
For decades, one of the most debated questions in gerontology was whether aging is a disease or the norm. At present, excellent reasoning suggests aging should be defined as a disease - indeed, aging has been referred to as "normal disease." Aging is the sum of all age-related diseases and this sum is the best biomarker of aging. Aging and its diseases ar...
Source: Fight Aging! - December 2, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Even Eliminating the Top Four Causes of Age-Related Death Gains Few Years of Life
Aging is a general process of deterioration, and any specific age-related disease, even one of the fatal conditions, is only a very narrow manifestation of that broad deterioration. It is a fantasy to think that any one specific age-related condition can be cured, entirely removed from the full spectrum of damage that is aging, in isolation, and without impact to the rest of aging. The only way to cure an age-related condition is to repair all of the forms of cell and tissue damage that cause it, and each type of damage has widespread effects beyond its contribution to any one named disease. Aging is treated all at once, o...
Source: Fight Aging! - November 28, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 26th 2018
This study is the culmination of a decade of research that has repeatedly demonstrated that this vaccine can effectively and safely target in animal models what we think may cause Alzheimer's disease. I believe we're getting close to testing this therapy in people."
Although earlier research established that antibodies significantly reduce amyloid buildup in the brain, researchers needed to find a safe way to introduce them into the body. A vaccine developed elsewhere showed promise in the early 2000s, but when tested in humans, it caused brain swelling in some patients. The new idea was to start with DNA coding for...
Source: Fight Aging! - November 25, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Atrophy of the Thymus Accelerates the Progression of Atherosclerosis
The thymus is where T cells mature, the training ground for the footsoldiers of the adaptive immune system. As the thymus declines in size and function with age, the supply of new T cells falls. This constrains and distorts the existing population of T cells, resulting eventually in chronic inflammation and immunosenescence, the failure the immune response and resulting vulnerability to pathogens and cancer. Atherosclerosis, meanwhile, is a condition of the innate immune system, in that it is caused by macrophages - a type of innate immune cell with origins that have nothing to do with the thymus - flocking to try and fail...
Source: Fight Aging! - November 23, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
