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Fight Aging! Newsletter, May 21st 2018
In conclusion, the connection between DNA damage and aging is emphasized by the secretion of senescence-associated proteins during cellular senescence, a phenotype which is activated by DNA damage and is common for both human and mice. Though much progress has been achieved, full understanding of these mechanisms has still a long way to go.
XPO1 as a Novel Target for Therapies to Enhance Autophagy
https://www.fightaging.org/archives/2018/05/xpo1-as-a-novel-target-for-therapies-to-enhance-autophagy/
Autophagy is the name given to a collection of cellular housekeeping processes that recycle damaged and un...
Source: Fight Aging! - May 20, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 14th 2018
This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition.
In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - May 13, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Geisinger to Perform Routine DNA Sequencing for 1,000 Patients in Pilot Study
We are entering an era in which DNA sequencing will become a routine laboratory test for a high percentage of patients. Geisinger, always a leader in innovation, is beginning the validation of this diagnostic approach (see:Geisinger to perform DNA sequencing as routine care). The key question, of course, is what actions hospital personnel will take based on this DNA information. This question is partly answered in the excerpt from the article below:Geisinger will soon roll out DNA sequencing as part of its preventive care for patients....Over the next six months, the Danville, Pa.-based system will enroll 1,000 patients in...
Source: Lab Soft News - May 10, 2018 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Genomic Testing Healthcare Delivery Healthcare Information Technology Healthcare Innovations Lab Industry Trends Lab Processes and Procedures Medical Consumerism Medical Research Medicole Source Type: blogs
Fight Aging! Newsletter, May 7th 2018
The objective here is a set of tests that (a) match up to the expected outcome based on human trials of mitochondrially targeted antioxidants, and (b) that anyone can run without the need to involve a physician, as that always adds significant time and expense. These tests are focused on the cardiovascular system, particularly measures influenced by vascular stiffness, and some consideration given to parameters relevant to oxidative stress and the development of atherosclerosis.
A standard blood test, with inflammatory markers.
An oxidized LDL cholesterol assessment.
Resting heart rate and blood pressure.
Heart r...
Source: Fight Aging! - May 6, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Ignorance based cardiology : What is the relationship between blood cholesterol and plaque cholesterol ?
Hyperlipidimia is one of the well-known coronary risk factor.Serum cholesterol ( Various fractions ) levels are measured to represent that risk. Epidemiologically ,it does a perfect job , however , the fact is , circulating lipids has little correlation with the lipids that’s deposited in the vessel wall.
Time and again , we have proven this as severity of CAD has little to do with the absolute levels of lipid levels.The number volume of plaques , the thickness of lipid core, and degree of vulnerability show poor correlation with circulating lipid levels than what we would expect.It tempts us to make a st...
Source: Dr.S.Venkatesan MD - May 5, 2018 Category: Cardiology Authors: dr s venkatesan Tags: Cardiology -Mechnisms of disease dyslipidemia hyperlipidemia stains and ldl cholesterol crystalisation plaque lipid vs serum lipid] relationship between serum lipid and plaque cad burden relationship between serum lipids and plaque lipid con Source Type: blogs
Fight Aging! Newsletter, April 30th 2018
In conclusion, in the Framingham Heart Study population, in the last 30 years, disease duration in persons with dementia has decreased. However, age-adjusted mortality risk has slightly decreased after 1977-1983. Consequences of such trends on dementia prevalence should be investigated.
Recent Research on the Benefits of Exercise in Later Life
https://www.fightaging.org/archives/2018/04/recent-research-on-the-benefits-of-exercise-in-later-life/
A sizable body of work points to the ability of older individuals to continue to obtain benefits through regular physical activity, and particularly in the case ...
Source: Fight Aging! - April 29, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 16th 2018
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - April 15, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
It ’ s not a white issue — it ’ s a grain issue. There is no such thing as “ healthy whole-grains ”
We’ve been told for decades that whole grains are healthy, healthier than processed white flour products. The flawed logic of replacing bad with less bad has thrown off an entire generation of dietitians, physicians, and government agencies charged with providing nutritional advice who have all embraced the less bad whole grains, going as far as urging all of us to make them the dominant ingredient in diet every day.
The misconception that whole grains are not just better for you, but healthy is simply not true. If we replace something bad–white flour products–with something less bad–whole grains–and there is an ...
Source: Wheat Belly Blog - April 10, 2018 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly blood sugar cholesterol diabetes Dr. Davis gluten grain grain-free grains healthy whole-grains joint pain Weight Loss Wheat Belly Total Health whole grains Source Type: blogs
There is no such thing as “ healthy whole-grains ”
We’ve been told for decades that whole grains are healthy, healthier than processed white flour products. The flawed logic of replacing bad with less bad has thrown off an entire generation of dietitians, physicians, and government agencies charged with providing nutritional advice who have all embraced the less bad whole grains, going as far as urging all of us to make them the dominant ingredient in diet every day.
The misconception that whole grains are not just better for you, but healthy is simply not true. If we replace something bad–white flour products–with something less bad–whole grains–and there is an ...
Source: Wheat Belly Blog - April 10, 2018 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly blood sugar cholesterol diabetes Dr. Davis gluten grain grain-free grains healthy whole-grains joint pain Weight Loss Wheat Belly Total Health whole grains Source Type: blogs
Mrs. Sprat got it right
(Image by Frederick Richardson via Wikimedia Commons.)
Jack Sprat could eat no fat.
His wife could eat no lean.
And so between the two of them,
They licked the platter clean.
If Jack Sprat could eat no fat . . . well, he’s going to be one sick, hungry guy. Fats, unlike carbohydrates, are essential, as necessary as water or oxygen.
If we are, at the core, hunting carnivorous creatures, a product of our unique evolutionary past, it’s easy to recognize that consuming the fat of animals is also part of our natural physiology. You and your hungry clan spear a wild boar, but no one declares “Just cut off a piece of lean m...
Source: Wheat Belly Blog - March 31, 2018 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle diabetes diy health Dr. Davis Fat gluten-free grain-free grains Inflammation low-carb saturated Source Type: blogs
Rethinking A1C goals for type 2 diabetes
“Treat the patient, not the number.” This is a very old and sound medical school teaching. However, when it comes to blood sugar control in diabetes, we have tended to treat the number, thinking that a lower number would equal better health.
Uncontrolled type 2 diabetes (also known as adult-onset diabetes) is associated with all sorts of very bad things: infections, angry nerve endings causing chronic pain, damaged kidneys, vision loss and blindness, blocked arteries causing heart attacks, strokes, and amputations… So of course, it made good sense that the lower the blood sugar, the lower the chances of bad things ha...
Source: Harvard Health Blog - March 26, 2018 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Diabetes Health Source Type: blogs
Fight Aging! Newsletter, March 26th 2018
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - March 25, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
10 Health Benefits of Daily Exercise
“A bear, however hard he tries, grows tubby without exercise.” – A. A. Milne
You don’t need to knock yourself out at the gym each day to reap the many health benefits of daily exercise. With simple planning and a determination to engage in a healthier lifestyle, you can add easy stints of exercise to your schedule without breaking too much of a sweat. Best of all, you may realize some of these 10 health benefits of daily exercise.
Exercise elevates your mood
When you are physically active, it stimulates brain chemicals that make you feel better and lifts your mood. Some experts say that exercise of any intensity, s...
Source: World of Psychology - March 21, 2018 Category: Psychiatry & Psychology Authors: Suzanne Kane Tags: Habits Health-related LifeHelper Self-Help Source Type: blogs
“ I have a wheat intolerance ”
I hear this comment with some regularity when, for instance, someone recognizes me as the author of the Wheat Belly series. This is a step in the right direction.
But saying that you have a wheat intolerance is like saying “I have a tobacco intolerance.” The impact of tobacco smoking on health ranges from mild impairment, to incapacitating diseases such as chronic lung disease and abdominal aortic aneurysms, to death. A rare person escapes the ravages of years of smoking, but most people develop at least one, if not half-a-dozen, health problems from cigarettes.
And so it goes with wheat: It’s a rare pers...
Source: Wheat Belly Blog - March 17, 2018 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle gluten gluten-free grain grain-free grains health Inflammation Source Type: blogs
How to use the Wheat Belly and Undoctored books for maximum benefit
There are 6 books in the entire Wheat Belly series dating back to September, 2011. It’s been a glorious few years watching so many people experience spectacular health and weight transformations doing the opposite of conventional dietary advice, with many of their stories highlighted here on the pages of the Wheat Belly Blog, as well as the Official Wheat Belly Facebook page.
Seasoned Wheat Belliers already know a lot about navigating the different content of the Wheat Belly books. But we’ve had so many newcomers that I thought it would be helpful to discuss how and when each of the Wheat Belly books can be use...
Source: Wheat Belly Blog - March 5, 2018 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle autoimmune blood sugar cholesterol diabetes edema grain-free grains Weight Loss Wheat Belly Total Health Source Type: blogs
