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Why “ Precision Health ” May Not Be the Precise Word
By DAVID SHAYWITZ, MD
The appeal of precision medicine is the promise that we can understand disease with greater specificity and fashion treatments that are more individualized and more effective.
A core tenet (or “central dogma,” as I wrote in 2015) of precision medicine is the idea that large disease categories – like type 2 diabetes – actually consist of multiple discernable subtypes, each with its own distinct characteristics and genetic drivers. As genetic and phenotypic research advances, the argument goes, diseases like “type 2 diabetes” will go the way of quaint descriptive diagnoses like “dropsy”...
Source: The Health Care Blog - November 28, 2017 Category: Consumer Health News Authors: John Irvine Tags: OP-ED Uncategorized Broad Institute CAD Circulation Disease Categories Gimish Model of Disease Kathiresan Khera Massachussetts General Hospital Source Type: blogs
A New Gimish Model of Complex Disease?
By DAVID SHAYWITZ, MD
The appeal of precision medicine is the promise that we can understand disease with greater specificity and fashion treatments that are more individualized and more effective.
A core tenet (or “central dogma,” as I wrote in 2015) of precision medicine is the idea that large disease categories – like type 2 diabetes – actually consist of multiple discernable subtypes, each with its own distinct characteristics and genetic drivers. As genetic and phenotypic research advances, the argument goes, diseases like “type 2 diabetes” will go the way of quaint descriptive diagnoses like “dropsy”...
Source: The Health Care Blog - November 28, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Broad Institute CAD Circulation Disease Categories Gimish Model of Disease Kathiresan Khera Massachussetts General Hospital Source Type: blogs
A More Precise Definition of Precision Medicine?
By DAVID SHAYWITZ, MD
The appeal of precision medicine is the promise that we can understand disease with greater specificity and fashion treatments that are more individualized and more effective.
A core tenet (or “central dogma,” as I wrote in 2015) of precision medicine is the idea that large disease categories – like type 2 diabetes – actually consist of multiple discernable subtypes, each with its own distinct characteristics and genetic drivers. As genetic and phenotypic research advances, the argument goes, diseases like “type 2 diabetes” will go the way of quaint descriptive diagnoses like “dropsy”...
Source: The Health Care Blog - November 28, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Broad Institute CAD Circulation Disease Categories Gimish Model of Disease Kathiresan Khera Massachussetts General Hospital Source Type: blogs
Fight Aging! Newsletter, November 27th 2017
We examined associations between mortality and accelerometer-measured PA using age-relevant intensity cutpoints in older women of various ethnicities.
The results support the hypothesis that higher levels of accelerometer-measured PA, even when below the moderate-intensity threshold recommended in current guidelines, are associated with lower all-cause and CVD mortality in women aged 63 to 99. Our findings expand on previous studies showing that higher self-reported PA reduces mortality in adults aged 60 and older, specifically in older women, and at less than recommended amounts. Moreover, our findings challenge th...
Source: Fight Aging! - November 26, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
James Peyer at TEDxStuttgart: Can We Defeat the Diseases of Aging?
My attention was drawn today to a recently published presentation by James Peyer. He heads up Apollo Ventures, one of the new crop of investment concerns focused on funding companies that are developing means to treat aging. These include the Longevity Fund, first out of the gate some years ago, as well as Juvenescence and the Methuselah Fund, created this year, and a repurposing of existing funds, such as Michael Greve's Kizoo ventures. Apollo Ventures is the source of the Geroscience online magazine that helps to advance and explain the position taken on aging by this group; this is something that more investors should d...
Source: Fight Aging! - November 23, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Health Care Needs Its Rosa Parks Moment
BY SHANNON BROWNLEE
On Wednesday, October 25, 2017 I was at the inaugural Society for Participatory Medicine conference. It was a fantastic day and the ending keynote was the superb Shannon Brownlee. It was great to catch up with her and I’m grateful that she agreed to let THCB publish her speech. Settle back with a cup of coffee (or as it’s Thanksgiving, perhaps something stronger), and enjoy–Matthew Holt
George Burns once said, the secret to a good sermon is to have a good beginning and a good ending—and to have the two as close together as possible. I think the same is true of final keynotes after a...
Source: The Health Care Blog - November 22, 2017 Category: Consumer Health News Authors: Matthew Holt Tags: OP-ED Patients Physicians Lown Institute Overtreatment Right Choice Alliance Shannon Brownlee Society for Participatory Medicine Source Type: blogs
My Husband Outlived His Brain Tumor Prognosis by 12 Years: How His Experience Could Help John McCain and Others
In conclusion, I would never advise John McCain and his family, or any other GBM patient, as to which of these treatments—or which combination of treatments—they should use. I hope they will learn about all of them, and decide on their own which one or ones they would like to try. I would also encourage them to do their own research, or to hire a researcher with experience in finding sensible, science-based, cutting-edge treatments.
I am very worried that they will not know about these treatments, and others like them, and will just use the standard of care. That would be a shame. It might also be a death sentence.
...
Source: HONEST MEDICINE: My Dream for the Future - November 21, 2017 Category: Consumer Health News Authors: JuliaS1573 at aol.com (Julia Schopick) Source Type: blogs
ICER Expanding Probe
A nonprofit group, the Institute for Clinical and Economic Review (ICER), recently received a three-year $13.9 million grant from the Laura and John Arnold Foundation to expand its ongoing investigative scope on drug pricing to include all new medicines and price increases on existing treatments.
Up until now, ICER hasn’t had the resources to review all new medicines. The additional funding “puts us on a new trajectory,” according to Steven D. Pearson, president of ICER. “Now we’re going to be able to cover the landscape.”
ICER was essentially founded with a $5.3 million grant from the Arnold Foundation in 20...
Source: Policy and Medicine - November 21, 2017 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
Conn TV Interviews Heart Health Expert Eliz Greene
Discussions with Physicians) online on behalf of Kowa Pharmaceuticals America, Inc., within the United States from July 7- August 4, 2017, among 5,014 U.S. adults aged 45 or older, who have been diagnosed with high cholesterol, and have ever used a statin to treat high cholesterol. This online survey is not based on a probability sample and therefore no estimate of theoretical sampling error can be calculated. For complete survey methodology, including weighting variables, please contact Erin Bittner at W2O Group, 212-301-7226.
GEN-2736
Eliz Greene survived a heart attack at age 35 while seven months pregnant with twins. ...
Source: Embrace Your Heart Wellness Initiative - November 20, 2017 Category: Cardiology Authors: Eliz Greene Tags: Award Winning Blog Events & Media Heart Health cholesterol Source Type: blogs
How does cholesterol affect the heart?
Discussions with Physicians) online on behalf of Kowa Pharmaceuticals America, Inc., within the United States from July 7- August 4, 2017, among 5,014 U.S. adults aged 45 or older, who have been diagnosed with high cholesterol, and have ever used a statin to treat high cholesterol. This online survey is not based on a probability sample and therefore no estimate of theoretical sampling error can be calculated. For complete survey methodology, including weighting variables, please contact Erin Bittner at W2O Group, 212-301-7226.
GEN-2736
Eliz Greene survived a heart attack at age 35 while seven months pregnant with twins. ...
Source: Embrace Your Heart Wellness Initiative - November 20, 2017 Category: Cardiology Authors: Eliz Greene Tags: Award Winning Blog Events & Media Heart Health cholesterol Source Type: blogs
An Open Letter to Dr. John Warner, President of the American Heart Association, on surviving a heart attack
Headlines today announce that the new President of the American Heart Association (AHA), cardiologist Dr. John Warner, has suffered a heart attack, aborted by an emergency stent placement. Typical of the ridiculous attitudes that prevail at the industry-friendly AHA, they Tweeted:
“Sending all our love and support to @American_Heart president Dr. Warner as he recovers from a mild heart attack. Heart disease can strike anyone, at any time. That’s why we keep fighting.”
If you ignore the nonsense that AHA policy dictates, you can absolutely gain control over cardiovascular risk. But you will NOT find the answer...
Source: Wheat Belly Blog - November 14, 2017 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle Source Type: blogs
MINOCA – Myocardial infarction with non obstructive coronary arteries
Myocardial infarction with non obstructive coronary arteries (MINOCA) [1] had a prevalence of 6% among myocardial infarctions noted in a recent systematic review [2]. They are more likely to be younger and female, but less often have dyslipidemia as a risk factor. Other risk factors were found to be similar. Total mortality at one year with MINOCA is about 4.7% compared to 6.7% with myocardial infarction associated with obstructive coronary artery disease. Typical myocardial infarction as demonstrated by cardiac magnetic resonance imaging (CMR) was noted only in about one fourth of cases. One third had myocarditis while ab...
Source: Cardiophile MD - November 14, 2017 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, November 13th 2017
In conclusion, we have developed an effective PILs strategy to deliver the AUF1 plasmid to a specific target, and this system may be useful for the development of new anti-aging drugs.
Considering the Evidence for Vascular Amyloidosis as a Cause of Aging
https://www.fightaging.org/archives/2017/11/considering-the-evidence-for-vascular-amyloidosis-as-a-cause-of-aging/
The balance of evidence for the aging of the cardiovascular system suggests the following view. It starts off in the blood vessels, with the accumulation of senescent cells and cross-links. Cross-links directly stiffen these tissues, while ...
Source: Fight Aging! - November 12, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
