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PROP ’s Disproportionate Influence on U.S. Opioid Policy: The Harms of Intended Consequences
ConclusionDespite being turned back from an effort to bluntly reduce opioid prescribing by the FDA in 2013 based on a lack of scientific evidence for its position (17,18), PROP has had a disproportionate effect on opioid policy in the Untied States for almost a decade. PROP found a willing federal regulatory partner in the CDC, and while PROP may not have “secretly written” the 2016 CDC Pain Guidelines (75), they certainly enjoyed disproportionate representation on CDC’s review panels and Core Expert Group (23-25) in a process that lacked transparency (22, 23, 26, 27). When the CDC admitted that its Pain Guideline had been...
Source: Pallimed: A Hospice and Palliative Medicine Blog - May 3, 2021 Category: Palliative Care Tags: CDC health policy kollas opioids pain prop Source Type: blogs

PROP ’s Disproportionate Influence on U.S. Opioid Policy: The Harms of Intended Consequences
ConclusionDespite being turned back from an effort to bluntly reduce opioid prescribing by the FDA in 2013 based on a lack of scientific evidence for its position (17,18), PROP has had a disproportionate effect on opioid policy in the Untied States for almost a decade. PROP found a willing federal regulatory partner in the CDC, and while PROP may not have “secretly written” the 2016 CDC Pain Guidelines (75), they certainly enjoyed disproportionate representation on CDC’s review panels and Core Expert Group (23-25) in a process that lacked transparency (22, 23, 26, 27). When the CDC admitted that its Pain Guideline ha...
Source: Pallimed: A Hospice and Palliative Medicine Blog - May 3, 2021 Category: Palliative Care Tags: CDC health policy kollas opioids pain prop Source Type: blogs

Talking Dogs And Ending Conversations: The Week ’s Best Psychology Links
Our weekly round-up of the best psychology coverage from elsewhere on the web A recent study has found that about two-thirds of conversations don’t end when we want them to. Researchers who monitored over 900 conversations found that most people wanted them to finish sooner, though a minority wanted them to continue for longer. This was true whether participants were talking to someone they had just met or a loved one, Adam Mastroianni tells Sean Illing at Vox. How is lockdown affecting the way people grieve? Dean Burnett looks at the science, and his own personal experience, at New Scientist. Yet mo...
Source: BPS RESEARCH DIGEST - April 23, 2021 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Weekly links Source Type: blogs

Oregon's Pioneering Effort to Enact State Law to Allow Access to Psilocybin
Kathryn L. Tucker, J. D., Oregon's Pioneering Effort to Enact State Law to Allow Access to Psilocybin, 57 Williamette L. Rev. (2020): Use of psilocybin reduces anxiety and depression when used as palliative care in cancer cases. Oregon is poised...
Source: HealthLawProf Blog - April 21, 2021 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs

Fight Aging! Newsletter, April 12th 2021
In conclusion, the MR exhibited the protective effects against age-related behavioral disorders, which could be partly explained by activating circulating FGF21 and promoting mitochondrial biogenesis, and consequently suppressing the neuroinflammation and oxidative damages. These results demonstrate that FGF21 can be used as a potential nutritional factor in dietary restriction-based strategies for improving cognition associated with neurodegeneration disorders. Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health https://www.fightaging.org/archives/2021/04/senescent-t-cells-cause-...
Source: Fight Aging! - April 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Oregon's Pioneering Effort to Enact State Law to Allow Access to Psilocybin
Kathryn L. Tucker, J. D., Oregon's Pioneering Effort to Enact State Law to Allow Access to Psilocybin, 57(1) Willamette L. Rev. (2020): Use of psilocybin reduces anxiety and depression when used as palliative care in cancer cases. Oregon is poised...
Source: HealthLawProf Blog - April 9, 2021 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs

Women, alcohol, and COVID-19
Excessive alcohol use is a common response to coping with stress. Alcohol use increased following the September 11th terrorist attacks and Hurricanes Katrina and Rita. The COVID-19 pandemic is following this same path. However, this pandemic is different in its scope and duration. COVID-19 is associated with both negative health and economic impacts, as well as grief, loss, and prolonged stress and uncertainty. The emotional impact of COVID-19 on women According to the U.S. National Pandemic Emotional Impact Report, compared to men, women reported higher rates of pandemic-related changes in productivity, sleep, mood, healt...
Source: Harvard Health Blog - April 6, 2021 Category: Consumer Health News Authors: Dawn Sugarman, PhD Tags: Addiction Alcohol Coronavirus and COVID-19 Women's Health Source Type: blogs

Joshua Greenberg on Antebellum Paper Money
George SelginAlerted by a tweet by him, I recently listened toa December 2020 C-SPAN talk, on " Paper Money in Antebellum America, " by historianJoshua Greenberg, the author ofBank Notes and Shinplasters: The Rage for Paper Money in the Early Republic.I haven ' t yet read his book. But Greenberg ' s talk is worth a listen. I was especially intrigued by his suggestion that, because they had to deal with so many different banknotes, including many of doubtful value, early Americans acquired a degree of financial savviness they sorely lack nowadays. Greenberg ' s related thesis that, by virtue of their very lack of uniformity...
Source: Cato-at-liberty - March 31, 2021 Category: American Health Authors: George Selgin Source Type: blogs

On Awe, Wonder, Biofeedback, CBSM, Virtual Reality, Privacy, Being Wrong, and more
Welcome to a new edition of SharpBrains’ e‑newsletter, this time featuring eleven timely resources and research findings for lifelong brain health and mental well-being. #1. “Awe is the feeling we experience when encountering vast things that we don’t understand. Around the world and in culturally varying ways, studies show, we experience awe in response to others’ kindness and courage, nature, music, religious or spiritual practice, the visual and dramatic arts, and epiphany … It leads us to share, collaborate, and wonder. In experiences of awe, people often speak as if they have found their soul.” Sometimes...
Source: SharpBrains - March 31, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Education & Lifelong Learning Peak Performance Technology & Innovation Applied Neuroscience AppliedVR awe biofeedback Blue Note Therapeutics CBSM consumer-reports digital health Happify Health heart-rate-vari Source Type: blogs

Nanoparticles On My Mind
By KIM BELLARD Nanoparticles are everywhere!  By that I mean, of course, that there seems to be a lot of news about them lately, particularly in regard to health and healthcare.   But, of course, literally they could be anywhere and everywhere, which helps account for their potential, and their potential danger. Let’s start with one of the more startling developments: a team at the University of Miami’s College of Engineering, led by Professor Sakhrat Khizroev, believes it has figured out a way to use nanoparticles to “talk” to the brain without wires or implants.  They use “a novel clas...
Source: The Health Care Blog - March 23, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Kim Bellard nanoparticles Source Type: blogs

A man in his 50s with acute chest pain and diffuse ST depression
Submitted by Alex Bracey, with edits by Meyers and SmithA man in his 50s with history of type B aortic dissection with prior TEVAR experienced acute onset chest pain at rest and presented to the Emergency Department. Here is his ECG on arrival:What do you think?Here is a prior ECG on file (presumed baseline):There is sinus rhythm with minimal STD in V5, V6, II, III, aVF. There is the tiniest amount of STE in aVL, but the T wave is not hyperacute (instead there is a terminal inversion). I would call this ECG consistent with subendocardial ischemia, but also the question of possible high lateral OMI (for which I am not ...
Source: Dr. Smith's ECG Blog - March 19, 2021 Category: Cardiology Authors: Pendell Source Type: blogs

Fight Aging! Newsletter, March 15th 2021
In conclusion, PLG attenuates high calcium/phosphate-induced vascular calcification by upregulating P53/PTEN signaling in VSMCs. Tsimane and Moseten Hunter-Gatherers Exhibit Minimal Levels of Atrial Fibrillation https://www.fightaging.org/archives/2021/03/tsimane-and-moseten-hunter-gatherers-exhibit-minimal-levels-of-atrial-fibrillation/ Epidemiological data for the Tsimane and Moseten populations in Bolivia shows that they suffer very little cardiovascular disease in later life, despite a presumably greater lifetime burden of infectious disease (and consequent inflammation) than is the case for people i...
Source: Fight Aging! - March 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Blue Note Therapeutics raises $26M to help treat cancer-related distress via cognitive behavioral stress management (CBSM)
Blue Note Therapeutics Raises $26.25 Million in Series A Financing (press release): Blue Note Therapeutics, Inc., today announced the closing of a Series A financing round of $26.25 million. Proceeds will allow the company to scale the organization and fund near-term clinical trials of its lead prescription digital therapeutic (PDT), which will potentially improve the treatment of cancer. The capital will also support the development of Blue Note’s pipeline assets. The Series A financing was led by JAZZ Venture Partners and joined by Summer VC. Blue Note Therapeutics is dedicated to serving patients suffering from cancer...
Source: SharpBrains - March 9, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Technology & Innovation anxiety Blue Note Therapeutics cancer-related distress cancer-treatment depression digital therapeutic Jazz Venture Partners medical devices prescription digital therapeutic psychosocial n Source Type: blogs

Fight Aging! Newsletter, March 8th 2021
Conclusion Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome. The Role of Reactive Oxygen Species in Aging is Complex https://www.fightaging.org/archives/2021/03/the-role-of-reactive-oxygen-species-in-ag...
Source: Fight Aging! - March 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Seeking solace, finding resilience in a pandemic
In times like these, it can feel wrong to feel happy. There is so much suffering in the world that appreciating the goodness that still exists can seem unempathic, if not altogether futile. A landmark study on happiness often mentioned at dinner parties and social gatherings (when we had those things) considered how people react to intense, sudden changes to their circumstances. The researchers found that people who had recently won the lottery were no happier after some time had passed than people who had experienced severe trauma that paralyzed their lower bodies. It’s a testament to stubbornness as our common lot in l...
Source: Harvard Health Blog - February 25, 2021 Category: Consumer Health News Authors: Adam P. Stern, MD Tags: Behavioral Health Coronavirus and COVID-19 Mental Health Source Type: blogs