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Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A man in his 50s with acute chest pain and history of prior MI
Written by Pendell MeyersA man in his 50s with prior history of anterior MI with LAD stent presented with acute chest pain similar but more intense than his last MI. He presented around midnight with pain that had started around 9pm the night before. He had taken NTG at home with no improvement, and immediately received morphine on arrival at the ED for severe chest pain (a very bad idea if your accuracy for finding OMI on ECG is low, since ongoing pain will be your last chance to identify those with ongoing untreated OMI).Here is his triage ECG at 0012:What do you think? What is the differential of this ECG?There is sinus...
Source: Dr. Smith's ECG Blog - April 13, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
A woman in her 30s with sudden chest pain, nausea, and diaphoresis. Was her cardiology management appropriate?
Case written and submitted by Brandon Fetterolf MD, edits by MeyersA woman in her early 30s with multiple autoimmune disorders including vasculitis presented with 2-3 hours of mid-left side chest discomfort with radiation to neck and left arm and associated with nausea, diaphoresis and dizziness. Initial ECG on presentation at 1554 (no prior for comparison):What do you think is happening to his 30s woman? The ECG shows NSR with a normal QRS except for poor R wave progression and pathologic QS-waves in V2-3. There is STE and hyperacute T waves in V2, I, and aVL with reciprocal STD in II, III, and aVF. This is...
Source: Dr. Smith's ECG Blog - April 8, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
An asymptomatic man in his 50s with heart rate in the 160s - what is the diagnosis? How will you manage this?
Written by Pendell MeyersA man in his late 50s with history of CAD with CABG, COPD, smoking, cirrhosis, and other comorbidities presented for an outpatient scheduled stress test which had been ordered for some exertional shortness of breath, palpitations, and presyncopal episodes over the past few months. When he presented to the office for the stress test, his screening vitals before any test or intervention were remarkable only for a heart rate of 160 bpm. He denied any symptoms whatsoever.A 12-lead ECG was performed in the office:What do you think?The ECG shows a wide complex regular monomorphic tachycardia. I mea...
Source: Dr. Smith's ECG Blog - April 2, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Arts Improve Quality of life for Stroke Survivors and People with Alzheimer's
Photo credit Crystal de Pasille Chabot
"Patients who appreciated music, painting and theatre recovered better from their stroke than patients who did not"Patients interested in art had better general health, found it easier to walk, and had more energy. They were also happier, less anxious or depressed, and felt calmer. They had better memory and were superior communicators (speaking with other people, understanding what people said, naming people and objects correctly)."
Read more on HealthCentral about how the arts can improve quality of life for stroke survivors:
Minding Our Elders: Caregivers Share Their Personal Stori...
Source: Minding Our Elders - March 28, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Weekly Overseas Health IT Links – 26th March, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.-----https://mhealthintelligence.com/news/55-of-telehealth-providers-frustrated-with-overblown-patient-expectations55% of Telehealth Providers Frustrated With Overblown Patient ExpectationsProviders also cited their ability to provide quality care and technical difficulties as among their top frustrations with telehealth, a new survey shows.ByAnuja VaidyaMarch 18, 202...
Source: Australian Health Information Technology - March 26, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Memorize the squiggly lines - it helps save lives.
Sent by Logan Stark, MD, written by Pendell MeyersDr. Stark sent me this ECG below and said " Curious on your thoughts without context. "Here is the PM Cardio version of this phone screenshot:I replied:" The concern without context would be possible LAD OMI signs. There is poor R wave progression, slight STE, hyperacute T waves in V2-V5, reciprocal STD in inferior leads. "He gave me the context:A middle aged man had sudden chest pain and arrested in front of his family. His wife immediately performed CPR.EMS arrived and defibrillated him. He was already awake and alert by arrival to the ED.He had persistent chest pain...
Source: Dr. Smith's ECG Blog - March 9, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, February 21st 2022
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far.
Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy
https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/
In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and here...
Source: Fight Aging! - February 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 31st 2022
In conclusion, the effects of MR on the gut barrier were likely related to alleviation of the oscillations of inflammation-related microbes. MR can enable nutritional intervention against age-related gut barrier dysfunction.
Clearing Senescent Cells from the Neural Stem Cell Niche Rapidly Improves Neurogenesis in Old Mice
https://www.fightaging.org/archives/2022/01/clearing-senescent-cells-from-the-neural-stem-cell-niche-rapidly-improves-neurogenesis-in-old-mice/
Neurogenesis is the generation of new neurons in the brain, and their integration into existing neural circuits. It is essential to learning an...
Source: Fight Aging! - January 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Coping when Both Parents Have Dementia
Photo credit Claudia Soraya
There are many different diseases that can cause different types of dementia. My dad's condition resulted from surgery, while Mom's developed more subtly—the type they used to call "senile dementia." Now it is called "organic brain disease." Whatever the type, Alzheimer's disease, vascular, Pick's disease, Parkinson's-related, or just plain "organic brain syndrome," it is painful for the caregiver. Sometimes the pain is so raw and isolating that the caregivers become more ill than those they are caring for. Statistics vary, but upward of thirty percent of caregivers die before the people they ...
Source: Minding Our Elders - December 26, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Unnecessary Evil: How Canada Ended up Insuring Bank Deposits
George SelginI ' ve often drawn attention here tothe virtues of the Canadian banking system, especially as it was between the passage of Canada ' s first Bank Act in 1871 and the establishment of the Bank of Canada in 1935. Afterthe Scottish banking system that flourished between 1716 and 1845, it is generally regarded, by myself and other members of theModern Free Banking school, as the next closest thing to a genuinely " free " banking system. We also claim that such systems tended to be more stable than ones in which governments interfered more heavily.In Canada ' s case, this claim inevitably raises several questions. ...
Source: Cato-at-liberty - November 15, 2021 Category: American Health Authors: George Selgin Source Type: blogs
Fight Aging! Newsletter, November 15th 2021
This article will review the relationship between diabetes mellitus and AD as it relates to tau pathology. More understanding of the link between diabetes mellitus and AD could change the approach researchers and clinicians take toward both diseases, potentially leading to new treatments and preventative strategies in the future.
Signaling from White Fat Tissue Contributes to Age-Related Hair Follicle Dysfunction
https://www.fightaging.org/archives/2021/11/signaling-from-white-fat-tissue-contributes-to-age-related-hair-follicle-dysfunction/
Changes in fat tissue behavior in the skin take place with age, ...
Source: Fight Aging! - November 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Autophagy is Protective in the Progression Towards Age-Related Hearing Loss
This open access paper provides a good summary of present thought on the contributing causes of hearing loss, in which the various issues of noise, aging, and toxicity cause harm via inducing stress in hair cells of the inner ear and their axonal connections to the brain. Autophagy is a cell maintenance process, the recycling of damaged component parts. More efficient autophagy helps hair cells to resist and survive a stressful environments, but autophagy declines with age. Defects arise in many of the component parts of the autophagic system and its regulation. This is likely why the threshold for loss of hair cells in re...
Source: Fight Aging! - November 12, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How I learned to let go of perfectionism: a lesson from my mother ’s suicide
My mother died 18 years ago today. It has probably taken me that long to be able to talk about it because, as survivors of suicide, our culture teaches us to live in shame. However, as I grow older, I have learned to let go of that shame. If you mention your experience with suicideRead more …How I learned to let go of perfectionism: a lesson from my mother’s suicide originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - November 7, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/erin-fenstermacher" rel="tag" > Erin Fenstermacher, MD < /a > < /span > Tags: Physician Practice Management Source Type: blogs
