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Fight Aging! Newsletter, July 12th 2021
In conclusion, our study demonstrated that elevated cumulative SBP or DBP was independently associated with increased risk of CVD in the Chinese population. Among participants with 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg-year for cumulative SBP/DBP, which was equivalent to maintaining SBP/DBP level higher than 131/83 mmHg in 15 years, the CVD risk would increase significantly irrespective of whether or not the BP measurements at one examination was high. Our findings emphasize the importance of cumulative BP level in identifying individuals with high risk of CVD in the future.
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Source: Fight Aging! - July 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Patience for Those Who Grieve
❝My son fricken tried to commit suicide, so I had to drive all the way over there to deal with it.A few months ago, I pulled up to the one remaining branch in my area that US Bank allowed to be open during the pandemic and tentatively approached the entrance. I had banking to do, but they had bizarrely limited hours and, of course, they were closed. So I entered the ATM area and began my bank transfers with hundreds of dollars tight to my chest, hoping nobody would come in and rob me blind while I was feeding the money into the ATM.As I was doing my banking in the comfort of their ATM fishbowl, a woman entered behind me....
Source: The Splintered Mind by Douglas Cootey - July 3, 2021 Category: Psychiatry Tags: Depression Goodreads Suicide Source Type: blogs
The explosion of mental health apps raises substantial opportunities –and tough questions
In the eyes of the tech industry, mental health treatment is an area ripe for disruption.
In any given year, 1 in 5 adults in the U.S. experience a form of mental illness, according to federal estimates. And research indicates only about half of them receive treatment in a system that is understaffed and ill distributed to meet demand.
For tech startups looking to cash in on unmet need, that translates into more than 50 million potential customers.
Venture capital firms invested more than $2.4 billion in digital behavioral health apps in 2020 — more than twice the amount invested in 2019 — touting support or treatment ...
Source: SharpBrains - June 28, 2021 Category: Neuroscience Authors: Kaiser Health News Tags: Brain/ Mental Health Technology & Innovation anxiety BetterHelp brain-illness Brightside cerebral depression digital behavioral health FDA Food and Drug Administration Ginger health apps mental illness mental-health-treatment Source Type: blogs
Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins."
Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
3 Ways To Add To Your Mental Health Toolbox
Mental Health is a hot topic right now, as it should be.
Celebrities coming out and openly talking about struggles, depression, and anxiety are getting more vocalized by the masses.
But what happens after these brave steps?
Unfortunately, you don't suddenly become healed, and the world is all rainbows and unicorns.
I am not a therapist, nor have I gone to school for any mental health training, but I am a regular person like you who has struggled with PTSD symptoms after an extremely tough breakup. Also, severe depression and anxiety after watching my father wither away from Parkinson's and then suddenly...
Source: PickTheBrain | Motivation and Self Improvement - June 4, 2021 Category: Consumer Health News Authors: Paul Marlow Tags: featured happiness health and fitness psychology self-improvement anxiety depression empowerment mental health pickthebrain Source Type: blogs
Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD.
Cell Signaling via Exosomes in the Development of Vascular Calcification
https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells caus...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Does the DEA Have to Allow Psilocybin Access for Terminally Ill Patients?
Trevor BurrusA case at the Ninth Circuit is seeking to compel the DEA to allow psilocybin (magic mushrooms) use by terminally ill patients. The case,Advanced Integrative Medical Science Institute v. DEA, has been brought by a research institute, a doctor, and two terminal cancer patients who wish to use psilocybin.A lot has changed in psilocybin research in recent years. In 2018 and 2019, the FDAdesignated two psilocybin trials as “breakthrough therapies” for treating severe depression.Breakthrough ‐therapy status can be granted by the FDA when a new drug shows significant improvement over currently...
Source: Cato-at-liberty - May 28, 2021 Category: American Health Authors: Trevor Burrus Source Type: blogs
Akili Interactive Labs raises $160M in equity and debt to transform cognitive healthcare via prescription videogame treatments
Akili raises $110m to build its digital therapeutics pipeline (pharmaforum):
EndeavorRx became the first and so far only approved prescription video game treatment in the US when it was cleared by the FDA last year to treat attention-deficit hyperactivity disorder (ADHD), and has also been given a green light in Europe.
It is also being tested for other indications including fuzzy thinking in COVID-19 survivors, a condition sometimes known as ‘brain fog’.
The new funding, which is accompanied by a $50 million loan facility, is earmarked for the continued rollout of the app as well as Akili’s pipeline of prescription ...
Source: SharpBrains - May 26, 2021 Category: Neuroscience Authors: SharpBrains Tags: Attention & ADD/ADHD Brain/ Mental Health Technology & Innovation Akili Akili Interactive Labs attention deficit hyperactivity disorder cognitive healthcare cognitive--disorders digital therapeutics EndeavorRx FDA Neuberger Berma Source Type: blogs
Epistemology VI: Epidemiology
Epidemiology originally largely meant studying how infectious diseases spread, and that ' s still a major concern of epidemiologists. However, it also includes the study of any and every environmental or behavioral factor affecting human health. For example, the finding that smoking tobacco causes lung cancer (not to mention a bazillion other diseases) is an epidemiological finding. Epidemiology is largely an observational science, given the ethical prohibition against exposing humans to potentially hazardous conditions for experimental purposes. That ' s not to say it hasn ' t been done, with the victims being ...
Source: Stayin' Alive - May 17, 2021 Category: American Health Source Type: blogs
Standing on Your Own Two Feet …at the bottom of the abyss
My chemotherapy for Hodgkin’s lymphoma started just four weeks after I got the cancerous vertebrae removed from my lower back. They’d inserted a metal cage inserted in its place, to hold my back together. The doctor said this procedure would keep me from being in a wheelchair for the rest of my life. I had just turned 33 years old.
But there I was: back in a wheelchair. Already. Just two chemo infusions into the long process ahead of me and I was responding so poorly that my body could no longer walk. I was feeling vulnerable, scared and scarred. I was dropping weight and popping pain pills. It was a time of e...
Source: PickTheBrain | Motivation and Self Improvement - May 13, 2021 Category: Consumer Health News Authors: Kristi Nelson Tags: confidence creativity depression featured happiness philosophy psychology self-improvement cancer empowerment healing inspiration motivation Source Type: blogs
5 inflammation-fighting food swaps
Inflammation: if you follow health news, you probably hear about it often. When is inflammation helpful? How can it be harmful? What steps can you take to tone it down?
What is inflammation and how does it affect your body?
If you’re not familiar with the term, inflammation refers to an immune system reaction to an infection or injury. In those instances, inflammation is a beneficial sign that your body is fighting to repair itself by sending in an army of healing white blood cells. As the injury heals or the illness is brought under control, inflammation subsides. You’ve probably seen this happen with a minor ankle sp...
Source: Harvard Health Blog - May 10, 2021 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Arthritis Autoimmune diseases Health Heart Health Nutrition Source Type: blogs
Fight Aging! Newsletter, May 10th 2021
This study suggests that some of those changes contribute to age-related hypertension, providing yet another reason to put resources into the near term development of therapies that can reverse the aging of the gut microbiome, such as flagellin vaccination or fecal microbiota transplantation.
"Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone) rat model, is different from that in animals with normal blood pressure. Further, transplanting dysbiotic gut microbiota from a hypertensive animal ...
Source: Fight Aging! - May 9, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Benefits of Taking a Break from Alcohol
Alcohol abuse and alcoholism are serious issues across the nation. In fact, there are over 95,000 alcohol-related deaths each and every year. Despite how problematic alcohol can be, it is still the most used substance across the country – many don’t realize the risks and health-related problems associated with alcohol.
Before we look at how taking even a short break can help you in the long-term let’s first look at the major risks associated with excessive alcohol use and binge drinking.
Major Risks of Alcohol Use
When it comes to alcohol abuse, there are many issues that can occur – from long-term physica...
Source: PickTheBrain | Motivation and Self Improvement - May 5, 2021 Category: Consumer Health News Authors: Joe Gilmore Tags: depression featured happiness health and fitness productivity tips self-improvement addiction alcohol self improvement Source Type: blogs
