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Optical Therapy Leads to Cancer Apoptosis
Researchers at Okayama University in Japan developed a novel technique to induce cancer cell apoptosis using light. The technology involves modifying the cells to express a light-sensitive protein that rapidly pumps hydrogen ions out of the cell when...
Source: Medgadget - April 5, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Source Type: blogs
IDIH Week 2022 on Active and Heathy Aging in Time of COVID – including US workshop 12 ET/9PT, Monday 21st
By ELIZABETH BROWN for CATALYST @ HEALTH 2.0
IDIH Week 2022 starts this coming Monday! It is a 4-day FREE online event hosted by Catalyst & our partner organizations that is dedicated to researchers, innovators, care providers and users associations dealing with Digital Health for Active and Healthy Ageing (AHA). IDIH Week is a unique occasion for R&I stakeholders from the US, Europe, and beyond to explore opportunities for international cooperation in the field of Digital Health for Active and Healthy Ageing, through information, networking and co-creation sessions that will be held betw...
Source: The Health Care Blog - March 18, 2022 Category: Consumer Health News Authors: matthew holt Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying re...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Altos Labs Officially Launches with $3 Billion in Funding to Tackle In Vivo Reprogramming
Altos Labs was formed to develop in vivo reprogramming into a viable class of therapies to treat aging. Reprogramming occurs during embryonic development, and the discovery of the Yamanaka factors allows this process to be enacted in any cell. To date this has largely been used in the development of induced pluripotent stem cells, a source of cells for research and therapy. The other effects of reprogramming are coming to be just as interesting, however: a resetting of the epigenetic marks characteristic of cells in old tissues, and a restoration of mitochondrial function. Studies in mice show that partial reprogramming, r...
Source: Fight Aging! - January 19, 2022 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Does College Education Make Us Act Healthier? Evidence from a Japanese Superstition
Yichen Shen (Waseda University), Rong FU (Waseda University), Haruko Noguchi (Waseda University), Does College Education Make Us Act Healthier? Evidence from a Japanese Superstition, SSRN (2021): We investigated the causal effect of college education on smoking, drinking, sleeping, and cancer...
Source: HealthLawProf Blog - December 16, 2021 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Fight Aging! Newsletter, November 22nd 2021
This study nicely illustrates the importance of the cellular metabolic state of myeloid cells: it highlights that not only the availability of glucose, but also its channeling into different pathways (glycolysis versus glycogen synthesis) contributes to maintaining proper myeloid function.
On the Ability of Redundant Blood Vessels to Lower Cardiovascular Mortality
https://www.fightaging.org/archives/2021/11/on-the-ability-of-redundant-blood-vessels-to-lower-cardiovascular-mortality/
A few strategies offer the possibility of growing additional redundant blood vessels, though this is far from rigorously pr...
Source: Fight Aging! - November 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Studying the Comparative Biology of Aging in Rockfish Species
Rockfish species vary widely in lifespan. Some even exhibit negligible senescence, showing few signs of aging across the majority of their long life spans. When closely related species have divergent life spans, there is perhaps the opportunity to learn something of how metabolism determines longevity. Accordingly, researchers here report on their study of varied rockfish species, in search of the differences in the molecular biology of cells that lead to differences in life span and pace of aging.
In a new study, researchers compare the genomes of nearly two-thirds of the known species of rockfish that inhabit co...
Source: Fight Aging! - November 19, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Breaking Up is Good to Do
By KIM BELLARD
Last week General Electric announced it was breaking itself up. GE is an American icon, part of America’s industrial landscape for the last 129 years, but the 21st century has not been kind to it. The breakup didn’t come as a complete surprise. Then later in the week Johnson and Johnson, another longtime American icon, also announced it would split itself up, and I thought, well, that’s interesting. When on the same day Toshiba said it was splitting itself up, I thought, hmm, I may have to write about this.
Healthcare is still in the consolidation phase, but there may be some lessons here for it....
Source: The Health Care Blog - November 16, 2021 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Finance The Business of Health Care Aetna conglomerates CVS-Aetna General Electric Johnson & Johnson Kim Bellard Optum Source Type: blogs
Digital Health Interests Of Pharma Giants Boehringer Ingelheim, Takeda, Astrazeneca, Amgen And Roche
With their extending reaches, resources and influence, pharmaceutical heavyweights have the potential to shape the digital health landscape to line up with their interests. And to have a better picture of where those interests lie, it is worth taking a look at what moves pharma giants are making in this sphere. With this in mind, we started a series of articles focusing on the digital health efforts of 14 global pharma companies.
The first article explored developments coming from Johnson & Johnson, Pfizer, Bayer and Novartis, while the second article investigated those coming from Merck, GlaxoSmithKline, AbbV...
Source: The Medical Futurist - November 4, 2021 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Artificial Intelligence in Medicine Digital Health Research Future of Pharma sleep patient empowerment pharmaceutics roche MySugr Astra-Zeneca DTx takeda Boehringer Ingelheim Amgen digitisation Quire.ai Renalytix Eko Source Type: blogs
Fight Aging! Newsletter, November 1st 2021
In conclusion, mitophagy pathways play an important role in maintaining physiological homeostasis, are involved in the mechanisms of aging and neurodegenerative disorders, and represent promising targets for the development of potential therapeutic agents aimed at regulating mitochondria quality control in neurons and glial cells. A significant number of molecules that induce or inhibit mitophagy are currently under consideration, which may be useful for testing hypotheses or developing drugs for the treatment of neurodegenerative diseases. The validation of promising drugs in animal and cell models, including neurons and ...
Source: Fight Aging! - October 31, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Extremely high HDL – beneficial or harmful?
This study showed extremely high HDL was associated with lower risks for all-cause mortality and cardiovascular events compared to low HDL. But they had higher risks compared to very high HDL.
Paradoxically high all-cause mortality in those with extremely high HDL has also been reported in another study of 52 268 men and 64 240 women [5].
Though most of these studies showed a negative role for extremely high HDL, there is recent study from Korea which showed that extremely high HDL was not associated with increased risk of mortality, myocardial infarction and stroke [6]. That study with 343,687 subjects also defined extrem...
Source: Cardiophile MD - October 20, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice.
To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, September 13th 2021
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - September 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
