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Fight Aging! Newsletter, March 22nd 2021
This article expresses sentiments regarding medical technology and human longevity that we'd all like to see more of in the mainstream media. At some point, it will come to be seen by the average person as basically sensible to work towards minimizing the tide of suffering and death caused aging and age-related disease. It has been, in hindsight, a strange thing to live in a world in which most people were reflexively opposed to that goal.
Death and aging constitute a mystery. Some of us die more quickly. We often ask about it as children, deny it in youth, and reluctantly come to accept it as adults. Aging is uni...
Source: Fight Aging! - March 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Future of Human Longevity will be Very Different from the Past
Human life expectancy has increased through two distinct process; firstly a reduction in child mortality, and second a reduction in the burden of damage accumulated over an adult life span. Control of infectious disease has played a large role in both components of gains in life expectancy. The trend has been slow. In recent decades, something like 0.2 years of life expectancy at birth and 0.1 years of remaining life expectancy at age 60 have been added with each passing calendar year.
Life expectancy is an artificial measure, of course: it is the length of life remaining, on average, assuming that nothing changes i...
Source: Fight Aging! - March 16, 2021 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
State of the lab 7 & 8 - The last years at EMBL
This is usually part of ayearly series of posts where I note down thoughts related to managing a research group in academia over the years. This post covers years 7 and 8 and it brings me now to the start of year 9, my last at EMBL. While I usually do one of these posts every year, with all of the craziness of 2020 I ended up skipping one. Year 7, group turnover 2019 was the year where the group fully turned over all lab members that were with us since the earlier years with 2 postdocs (Haruna Imamura and David Ochoa) and 3 PhD students (David Bradley, Claudia Hernandez-Armenta and Marta Strumillo) leaving. ...
Source: Evolution of Cellular Networks - January 29, 2021 Category: Cytology Tags: state of the lab Source Type: blogs
Fight Aging! Newsletter, August 17th 2020
In this study, we sought to elucidate the role of VRK-1 in regulation of adult life span in C. elegans. We found that overexpression of VRK-1::GFP (green fluorescent protein), which was detected in the nuclei of cells in multiple somatic tissues, including the intestine, increased life span. Conversely, genetic inhibition of vrk-1 decreased life span. We further showed that vrk-1 was essential for the increased life span of mitochondrial respiratory mutants. We demonstrated that VRK-1 was responsible for increasing the level of active and phosphorylated form of AMPK, thus promoting longevity.
A Fisetin Variant, C...
Source: Fight Aging! - August 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Does the U.S. Semiconductor Industry Really Need Urgent Taxpayer Support to Stop China?
Scott LincicomeToday, the United States Senateapproved the FY2021 National Defense Authorization Act (NDAA), which contains anamendment passed earlier this week, with little floor debate and by a 96-4 margin, that would provide billions of dollars in new federal support for the U.S. semiconductor industry, most notably tax credits and grants for the construction of new domestic manufacturing facilities. The Housepassed a similar bill with asimilar amendment earlier this week, so the legislation now goes to conference, where the subsidies are expected to survive. The two main reasons for the Senate and House amendments (...
Source: Cato-at-liberty - July 23, 2020 Category: American Health Authors: Scott Lincicome Source Type: blogs
A new hormonal therapy for prostate cancer is under expedited FDA review
In June, the US Food and Drug Administration (FDA) launched an accelerated review of a promising new drug for advanced prostate cancer. Called relugolix, it suppresses testosterone and other hormones that speed the cancer’s growth. If approved, this new type of hormonal therapy is expected to set a new standard of care for the disease.
Doctors give hormonal therapies when a man’s tumor is metastasizing (spreading beyond the prostate), or if his PSA levels start rising after surgery or radiation. The most commonly used hormonal therapies, called LHRH agonists, will eventually lower testosterone levels in blood. ...
Source: Harvard Health Blog - July 13, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Prostate Knowledge Treatments HPK Source Type: blogs
I feel your pain
In the May issue of the journal Cerebral Cortex, a group from the National Institute for Physiological Sciences in Okazaki, Japan reported interesting results from a study in which “pain centers” in the brain were shown to be activated by WITNESSING pain afflicted to others. If you see someone being poked with a sharp needle in a (fake) movie, your brain responds as if YOU’VE been poked, and your brain responds as if YOU hurt. (I can almost see you wincing, as you read this!)
IT HURTS, WHEN YOU THINK IT SHOULD. If I flash a red light each time I burn your skin, you’ll learn that the red light means...
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - July 1, 2020 Category: Neuroscience Authors: Dr. Merzenich Tags: Aging and the Brain Brain Fitness Brain Trauma, Injury BrainHQ Cognitive impairments Posit Science Source Type: blogs
Exploring Nature ’s Treasure Trove of Helpful Compounds
A cone snail shell. Credit: Kerry Matz, University of Utah.
Over the years, scientists have discovered many compounds in nature that have led to the development of medications. For instance, the molecular structure for aspirin came from willow tree bark, and penicillin was found in a type of mold. And uses of natural products aren’t limited to medicine cabinet staples and antibiotics. A cancer drug was originally found in the bark of the Pacific yew tree, and a medication for chronic pain relief was first isolated from cone snail venom. Today, NIGMS supports scientists in the earliest stages of investigating natural pro...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 24, 2020 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Bacteria Cool Tools/Techniques Medicines Microbes Source Type: blogs
Can forest therapy enhance health and well-being?
According to this study, green spaces are restorative and boost attention, while viewing concrete worsens attention during tasks.
Finding a forest therapy guide
The Association of Nature and Forest Therapy trains and certifies forest therapy guides across the world. Guides help people forge a partnership with nature through a series of invitations that allow participants to become attentive to the forest, to deepen their relationship with nature, and allow the natural world to promote healing and well-being.
Ultimately, guides support what the forests have to offer us, inviting participants into practices that deepen physi...
Source: Harvard Health Blog - May 29, 2020 Category: Consumer Health News Authors: Susan Abookire, BSEE, MD, MPH, FACP Tags: Exercise and Fitness Health Mental Health Stress Source Type: blogs
Choosing Between Life and Death During COVID-19: The A.I. Trolley Problem
Suppose you’re the sole witness of a trolley that has gone out of control, hurtling towards 5 people tied to its track, with no way to stop it in time. Good news: there’s a lever you can pull to alter its direction. Bad news: the other track isn’t safe either as it has one person tied to it. What will you do in this situation? Let the trolley continue on its initial course and kill those 5 people on the way or pull the lever to save them at the expense of that other person’s life?
Source: https://www.lionsroar.com/
This ethical thought experiment, known as the Trolley Problem, was put forth by Philippa Foot b...
Source: The Medical Futurist - May 14, 2020 Category: Information Technology Authors: Prans Tags: Artificial Intelligence Bioethics Future of Medicine Healthcare Policy covid19 Source Type: blogs
Fight Aging! Newsletter, April 27th 2020
In conclusion, our study demonstrated that Nrf2 deficiency promoted the increasing trend of autophagy during aging in skeletal muscle. Nrf2 deficiency and increasing age may cause excessive autophagy in skeletal muscle, which can be a potential mechanism for the development of sarcopenia.
To What Degree is Chondrocyte Hypertrophy in Osteoarthritis Due to Cellular Senescence?
https://www.fightaging.org/archives/2020/04/to-what-degree-is-chondrocyte-hypertrophy-in-osteoarthritis-due-to-cellular-senescence/
Senescent cells are large. They do not replicate, that function is disabled, but it is as if they go ...
Source: Fight Aging! - April 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 20th 2020
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum.
Blood Metabolites as a Marker of Frailty
https://www.fightaging.org/archives/2020/04/blood-metabolites-as-a-marker-of-frailty/
Frailty in older people is usually diagnosed in a symptomatic ...
Source: Fight Aging! - April 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 13th 2020
This study is par for the course, looking at Japanese Olympic participants. Interestingly, it hints at the upper end of the dose-response curve for physical activity, in that a longer career as a professional athlete may be detrimental in comparison to lesser degrees of exercise and training.
From this large, retrospective cohort study targeting 3546 Japanese Olympic athletes, we observed significant lower mortality among Olympians compared with the Japanese general population. The overall standardised mortality ratio (SMR) was 0.29. The results were consistent with previous studies conducted in other non-Asian co...
Source: Fight Aging! - April 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted.
Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
