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Fight Aging! Newsletter, December 7th 2020
In this study, except for the reduction in body weight, the aging characteristics related to epidermal and muscle tissue in mice were significantly ameliorated in the CR group compared with the control group. Additional studies have indicated that not stem cells themselves but the stem cell microenvironment is the key factor mediating stem cell activation, proliferation and differentiation.
Mitochondrial dysfunction is an important factor leading to age-related muscular atrophy. Considering the dependence of skeletal muscle on ATP, loss of mitochondrial function, which can lead to a decrease in strength and enduranc...
Source: Fight Aging! - December 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Vivo Reprogramming Reverses Vision Loss and Damage in a Mouse Model of Glaucoma
Several research groups and companies are working on in vivo applications of cellular reprogramming. Today's research materials cover recent work from David Sinclair's team showing off the use of reprogramming to produce regeneration of damaged nervous system tissue in the eye and optic nerve. Glaucoma is a condition in which rising pressure in the eyeball progressively harms the retina and optic nerve. Since nerve tissue doesn't regenerate well in mammals, loss of vision is irreversible. This is one of many conditions for which the ability to regenerate nerve tissue would be a great benefit.
Since its discovery, re...
Source: Fight Aging! - December 3, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 30th 2020
We examined specific aspects of metabolism in male PolG+/mut mice at 6 and 12 months of age under three dietary conditions: normal chow (NC) feeding, high-fat feeding (HFD), and 24-hr starvation. We performed mitochondrial proteomics and assessed dynamics and quality control signaling in muscle and liver to determine whether mitochondria respond to mtDNA point mutations by altering morphology and turnover. In the current study, we observed that the accumulation of mtDNA point mutations failed to disrupt metabolic homeostasis and insulin action in male mice, but with aging, metabolic health was likely preserved by counterme...
Source: Fight Aging! - November 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations.
Data on the Prevalence of Liver Fibrosis in Middle Age
https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/
Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options a...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Extracellular Vesicle Signals in Older Individuals Alter Hematopoietic Stem Cell Activity
Stem cell activity declines with age, due in part to damage to these cells and their niches, but perhaps to a greater degree due to changes in the signaling environment resulting from rising levels of molecular damage and consequent dysfunction throughout the body. Not all of these signaling changes are obviously harmful; some are attempts to compensate. Some of those attempts produce benefits, slowing the overall pace of decline, but also unwanted side-effects. Researchers here note that the contents of extracellular vesicles released by cells change with age, and that hematopoietic stem cells react to vesicles from older...
Source: Fight Aging! - November 18, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 16th 2020
This study conclusively demonstrates the long-speculated relationship between aging, gene regulation, and somatic damage. The results open up new avenues of research with practical implications. If the same level of coordination reduction between genes is indeed a leading cause for aging phenomena, there may be a need to change course in current efforts to develop aging treatments.
Using Oligodendrocyte Extracellular Vesicles to Induce Tolerance to Myelin as a Treatment for Multiple Sclerosis
https://www.fightaging.org/archives/2020/11/using-oligodendrocyte-extracellular-vesicles-to-induce-tolerance-to-myelin-a...
Source: Fight Aging! - November 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Strategies to Treat Vascular Aging
The vascular system does not age gracefully. Blood vessel walls become stiff and inflamed, interfering in contraction and dilation in response to circumstances. The result is the raised blood pressure of hypertension, which causes damage throughout the body in numerous ways. Further, the fatty lesions of atherosclerosis form in later life, weakening and narrowing blood vessels. This is the result of increased levels of oxidized cholesterol molecules, causing the macrophages responsible for cleaning up blood vessel wall tissues to falter in their tasks. Further still, the blood-brain barrier that lines blood vessels in the ...
Source: Fight Aging! - November 13, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
FOXO is Involved in the Preservation of Muscle Stem Cell Function with Age
Researchers here note that the FOXO signaling pathway appears to help maintain function in a subset of muscle stem cells all the way into later life. Muscle stem cell activity declines with age, even while the evidence suggests that the populations are largely intact and able to act if placed into a more youthful environment. This decline may be an evolved reaction to the molecular damage of aging that serves to reduce the cancer risk inherent in cell activity in a damaging environment, or it may be the consequence of damage and dysfunction in the stem cell niche in which muscle stem cells reside, or both. This loss of ste...
Source: Fight Aging! - November 3, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
9 Technologies That Will Shape The Future Of Dentistry
One of the most common childhood fears is going to the dentist. Who would not relate? Sitting in a huge chair illuminated by blinding light; enduring lengthy seated sessions with someone looking and poking inside your mouth using edgy and frightening devices. And finally, when the torture is over, that same someone tells you not to eat your favourite sweets and instructs you to brush your teeth regularly.
We’ve all been through this as a kid and childhood memories stick with us; just recalling this might send a shiver down your spine. No one likes to go to the dentist in spite of the fact that everyone knows how crucia...
Source: The Medical Futurist - November 3, 2020 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Artificial Intelligence in Medicine Biotechnology E-Patients Future of Medicine Future of Pharma Genomics Health Sensors & Trackers Medical Education Telemedicine & Smartphones Virtual Reality AI augmented reality dig Source Type: blogs
Fight Aging! Newsletter, November 2nd 2020
In conclusion, the circulating antibody repertoire has increased binding to thousands of peptides in older donors, which can be represented as an immune age. Increased immune age is associated with autoimmune disease, acute inflammatory disease severity, and may be a broadly relevant biomarker of immune function in health, disease, and therapeutic intervention. The immune age has the potential for wide-spread use in clinical and consumer settings.
In Vivo Reprogramming Improves Cognitive Function in Old Mice
https://www.fightaging.org/archives/2020/10/in-vivo-reprogramming-improves-cognitive-function-in-old-mic...
Source: Fight Aging! - November 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Another New Senolytic Prodrug is Demonstrated to Reverse Frailty and Cognitive Function in Old Mice
Today's open access paper reports on the use of a prodrug senolytic strategy to reverse aspects of aging in mice via the selective destruction of senescent cells. A prodrug is a small molecule, usually innocuous, that can be converted into an active drug molecule by the action of specific proteins in the body. For example a drug can be made into a prodrug by the addition of further chemical structure that (a) renders it inert, and (b) is cleaved away by an enzyme inside cells. Ideally, the inactive prodrug is designed such that this conversion to an active drug molecule only takes place where and when the drug is needed.
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Source: Fight Aging! - October 28, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Another New Senolytic Prodrug is Demonstrated to Reverse Frailty and Loss of Cognitive Function in Old Mice
Today's open access paper reports on the use of a prodrug senolytic strategy to reverse aspects of aging in mice via the selective destruction of senescent cells. A prodrug is a small molecule, usually innocuous, that can be converted into an active drug molecule by the action of specific proteins in the body. For example a drug can be made into a prodrug by the addition of further chemical structure that (a) renders it inert, and (b) is cleaved away by an enzyme inside cells. Ideally, the inactive prodrug is designed such that this conversion to an active drug molecule only takes place where and when the drug is needed.
...
Source: Fight Aging! - October 28, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Resting Metabolic Rate in Aging and Age-Related Disease
Resting metabolic rate declines with age, a situation that has evolved for perhaps much the same reasons as loss of stem cell function, in that it is one part of the trade-off between risk of death by cancer on the one hand versus organ failure due to faltering tissue maintenance on the other. Researchers here note that this reduction in resting metabolic rate is attenuated by the presence of age-related diseases. Why would age-related disease cause a relative increase in resting metabolic rate? Perhaps because the body is devoting more energy to fighting the condition, or perhaps the disease processes themselves, such as ...
Source: Fight Aging! - October 28, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
In Vivo Reprogramming Improves Cognitive Function in Old Mice
In this study, we addressed age-dependent changes in brain structures susceptible to premature degeneration. It has been postulated that age-related brain decline mirrors developmental maturation and, accordingly, brain structures with a late development may be the first to degenerate. This notion was first described as Ribot's law. The dentate gyrus (DG) exemplifies a brain structure that matures after birth and whose functions decline early with age. For example, the DG of 10-month-old mice shows a clear decrease in adult neurogenesis, the process through which functional neurons are generated from adult neural precursor...
Source: Fight Aging! - October 26, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
