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Therapy: Stem Cell Therapy

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Total 1175 results found since Jan 2013.

Natural Killer Cells Oppose In Vivo Reprogramming
We report that natural killer (NK) cells significantly limit reprogramming, both in vitro and in vivo. Cells and tissues in the intermediate states of reprogramming upregulate the expression of NK-activating ligands, such as MULT1 and ICAM1. NK cells recognize and kill partially reprogrammed cells in a degranulation-dependent manner. Importantly, in vivo partial reprogramming is strongly reduced by adoptive transfer of NK cells, whereas it is significantly increased by their depletion. Notably, in the absence of NK cells, the pancreatic organoids derived from OSKM-expressing mice are remarkably large, suggesting that ablat...
Source: Fight Aging! - May 2, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Supporting Evidence for Somatic Mutations to be an Important Contributing Cause of Aging
In today's open access paper, researchers presented data on the pace at which random mutational damage accumulates in the nuclear DNA of somatic cells over a lifetime, covering a range of mammalian species with differing body sizes and life spans. They looked only at the lining of the gut, a tissue in which cells replicate rapidly, and thus one might expect to find more mutations and thus data that is more easily analyzed. The researchers found that the burden of mutations in late life is remarkably consistent, the rate of mutation inversely correlated with species life span. This is suggestive that somatic mutations are e...
Source: Fight Aging! - April 27, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

An Outline of Present Work on Partial Reprogramming as a Rejuvenation Therapy
Here I'll point out a good, lengthy introduction to the ongoing, suddenly very well funded work on partial reprogramming as the basis for rejuvenation therapies. Reprogramming somatic cells to induced pluripotent stem cells requires exposure to the Yamanaka factors, but is a lengthy process with low efficiency. Early in that process, epigenetic patterns in a cell are restored to a more youthful configuration without the loss of differentiated somatic cell state, and this is the goal that partial reprogramming aims to achieve: restore mitochondrial function and many other cell activities in old tissues without changing cell...
Source: Fight Aging! - April 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, April 25th 2022
We examined central genetic and environmental lifespan regulators (putative anti-aging interventions, PAAIs; the following PAAIs were examined: mTOR loss-of-function, loss-of-function in growth hormone signaling, dietary restriction) for a possible countering of the signs and symptoms of aging. Importantly, in our study design, we included young treated groups of animals, subjected to PAAIs prior to the onset of detectable age-dependent phenotypic change. In parallel to our studies in mice, we assessed genetic variants for their effects on age-sensitive phenotypes in humans. We observed that, surprisingly, many PAAI...
Source: Fight Aging! - April 24, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, April 11th 2022
In conclusion, plasma levels of IGHA2, APOA and HPT are associated with subclinical atherosclerosis independently of traditional risk factors and offers potential to predict this disease. The panel could improve primary prevention strategies in areas where imaging is not available. A Lesser Diversity of Circulating Antibodies in the Aging Killifish Immune System https://www.fightaging.org/archives/2022/04/a-lesser-diversity-of-circulating-antibodies-in-the-aging-killifish-immune-system/ Short-lived killifish are one of the more recently adopted animal models of aging. All such models are a trade-off betw...
Source: Fight Aging! - April 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, April 4th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Considering Stem Cells in the Context of Cancer and Aging
Is it useful to think of cancer as a stem cell disease, a condition that (largely) arises because stem cells become dysfunctional? The evidence seems to suggest that at least some cancers arise from somatic cells taking on stem cell properties, while a body of work indicates that at least some cancerous tissues are supported by small populations of cancer stem cells that might be targeted for destruction. Here researchers are interested in the bigger picture, the nature of the relationship between stem cell function, stem cell resilience, cancer, and aging. In an era that will soon enough seen the widespread use of regener...
Source: Fight Aging! - March 30, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Discussion of Applying Partial Reprogramming to Senescent Cells In Vivo
Partial reprogramming exposes cells to the Yamanaka factors for long enough to reset their epigenetic patterns to those of a youthful cell, but not so long as to force a change of state into induced pluripotent stem cells. This is an active area of research, not yet an exact science in practice, and the long-term risk of cancer via current techniques remains unknown, but animal studies have produced promising results in the short term when it comes to improved function following the application of a partial reprogramming therapy. What will partial reprogramming do to senescent cells? In today's open access paper, re...
Source: Fight Aging! - March 24, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

3D Printed Testicular Cells Offer Hope for Male Infertility
Researchers at the University of British Columbia have developed a technique that lets them 3D print human testicular cells into a hollow tubular structure that mimics the seminiferous tubules found in the testicles. The printed structures are showin...
Source: Medgadget - March 24, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Reproductive Medicine ubc Source Type: blogs

Fight Aging! Newsletter, March 21st 2022
This study was the first to examine how these networks interact with physical activity and fitness to impact how the brain functions. "This paper is exciting because it gives us some evidence that when people whose brain networks aren't functioning optimally engage in physical activity, we see improvement in their executive function and their independence. Maybe just take the stairs on the way to work. Stand up and walk around a little bit more. That's where you get the most bang for your buck, not crazy, high-intensity exercise." Variations in Biological Age Across Organs in Younger Individuals https://...
Source: Fight Aging! - March 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Interaction Between Metabolism and Stem Cell Aging
In today's open access paper, researchers discuss the influence of metabolism on the aging of stem cells. Stem cells maintain tissue by providing a supply of daughter somatic cells to replace losses. Animals have evolved to minimize the risk of cancer by limiting the ability of near all cells to replicate. Somatic cells operate under the Hayflick limit, driven by loss of telomere length with each cell division, leading to senescence or self-destruction when telomeres are short. Stem cells use telomerase to maintain long telomeres and thus continually produce replacement somatic cells with long telomeres. Unfortunate...
Source: Fight Aging! - March 17, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Cell Reprogramming via RNA Therapies
Gene therapies delivering mRNA produce a temporary production of proteins. An RNA molecule acts as a blueprint for a ribosome to assemble many copies of a specific protein, but this doesn't last long, and a few days of protein expression from a single treatment is a reasonable expectation in practice. This make RNA therapies suitable to produce partial reprogramming in an animal or patient. The Yamanaka factors are delivered for a long enough period of time to rejuvenate epigenetic patterns and restore mitochondrial function, but (hopefully) not long enough to convert any meaningful number of somatic cells into induced plu...
Source: Fight Aging! - March 15, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs