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Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a po...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
OneSkin Launches a Topical Senolytic Treatment
Senescent cells are damaging to tissue function and health when they linger and grow in number, as becomes the case with age. They contribute to the chronic inflammation of aging via their signaling, the senescence-associated secretory phenotype. In skin, senescent cells are most likely responsible for a sizable fraction of the more problematic later life skin aging, in the 50s and on. It is less clear and less likely that they have much do to with the changes seen from the late 20s into the 40s.
The primary advantage inherent in targeting the mechanisms of aging specifically in skin is that the regulatory path to m...
Source: Fight Aging! - October 22, 2020 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
BMP6 as a Target for Pro-Angiogenic Therapies
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a potential target to increase or diminish that process. Angiogenesis is very well studied by the cancer community, in the context of how tumors subvert tissue signaling to support themselves via the generation of blood vessel networks. Angiogenesis is perhaps an underappreciated topic in the study of aging, however, and particularly with regard to the treatment of aging as a medical condition. There is a good argument to be made that the observed loss of capillary density in older individual...
Source: Fight Aging! - October 21, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Chromatin Changes in the Aging of Stem Cells
Chromatin is the name given to the packed structure of nuclear DNA and surrounding molecules, tightly coiled in the center of the cell. Chromatin structure and the molecules responsible for regulating that structure are a part of the complex epigenetic systems that determine the pace of protein production, and thus cell behavior. Chromatin changes in characteristic ways with age, a situation that is far from fully mapped and understood, but is particularly important in stem cell aging. Stem cell populations become less active with age, most likely an evolved response to rising levels of tissue damage that acts to limit the...
Source: Fight Aging! - October 21, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 19th 2020
In conclusion, we found that regardless of the presence of multimorbidity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and 7.6 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, with smoking being significantly worse than others.
A Hydrogel Scaffold to Encourage Peripheral Nerve Regeneration
https://www.fightaging.org/archives/2020/10/a-hydrogel-scaffold-to-encourage-peripheral-nerve-regeneration/
The nervous system of mammals is poorly regenerative at best. The use of implantable scaffold materials is one of the...
Source: Fight Aging! - October 18, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
COVID-19 as a Disease of Aging
Researchers are writing a great many papers these days to point out the obvious regarding COVID-19, that the vast majority of SARS-CoV-2 coronavirus mortality occurs in olders individuals, particularly those who already suffer age-related disease and thus a high burden of tissue and immune system dysfunction. This process of repeating the obvious seems necessary, given that the public discourse on the topic of the present pandemic presents it as a condition that affects all members of society more or less equally. In fact it is a condition that does little more than inconvenience near all younger people who are infected, w...
Source: Fight Aging! - October 15, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Towards Harnessing Growth to Create Rejuvenation
A recent pair of open access papers offer an interesting viewpoint on embryonic development, aging, cancer, and possible approaches to rejuvenation in this era of biotechnology. I'm not sure that I agree with more than half of it, but it does make for a good read, even given that the language is somewhat obtuse in places. Tissue growth is the unifying process, wherein: (a) embryonic development is the epitome of regulated, successful, beneficial growth; (b) aging suppresses and damages the shackled processes of growth that are turned to tissue maintenance; (c) cancer is unfettered and uncontrolled growth; and (d) the resea...
Source: Fight Aging! - October 12, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 12th 2020
We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour, and locomotor activity remained unaffected.
This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed. Finally, the detrimental effect of FMT from aged donors on the CNS was confir...
Source: Fight Aging! - October 11, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Delivery of T Cell Progenitor Cells as an Approach to Thymic Regeneration
The thymus is a small organ in which thymocytes generated in the bone marrow mature to become T cells of the adaptive immune system. Unfortunately, the thymus atrophies with age, its active tissue largely replaced by fat in most people by age 50 or so. Thereafter the adaptive immune system declines into immunosenescence and inflammaging, deprived of a sufficiently large supply of reinforcement cells. Given the importance of the immune system to health, in matters including tissue maintenance, resistance to infection, suppression of cancer, and more, regeneration of the thymus must be an important component of any serious e...
Source: Fight Aging! - October 7, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 5th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 4, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Injection of Metformin Improves Cognitive Function in Old Mice to a Greater Degree than Oral Administration
Researchers here note that delivering metformin via injection rather than the usual oral administration removes unwanted side-effects and better improves cognitive function in old mice. Near all testing of metformin has used oral administration, and the effects on pace of aging and life span are, frankly, too unreliable and too small to justify the present level of interest in the drug on the part of the longevity community. Administration by injection might be a different story, but waiting on further research and confirming data would be a wiser course of action than immediate excitement. Even then, this is tinkering wit...
Source: Fight Aging! - September 28, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Naringenin is a Senotherapeutic that Enhances Neurogenesis in Mice
Researchers here evaluate the flavonoid naringenin for its ability to dampen the inflammatory signaling of senescent neural cells, particularly levels of TNF-α, and increase neurogenesis in mice. This increased neurogenesis is likely a result of reduced inflammation in brain tissue, but possibly due to other, distinct mechanisms. Neurogenesis is the name given to the generation of new neurons in the brain, and their integration into existing neural circuits. Evidence suggests that increased neurogenesis is a good thing at any age, improving cognitive function and making the brain more resilient to injury. Now that the res...
Source: Fight Aging! - September 25, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Discussion of Targeting the Mechanisms of Cardiovascular Aging
This very readable open access paper discusses some of the mechanisms involved in cardiovascular aging. As for many such publications, and to my eyes at least, it leans too much towards the details of the aged metabolism rather than towards the underlying causes that make the cells of an aged cardiovascular system behave differently. Near all medicine for age-related disease has so far focused on trying to change the way in which cells behave in response to the causes of aging, without addressing those causes, and, as a result, beneficial outcomes have been marginal at best. It is somewhere between very hard and impossible...
Source: Fight Aging! - September 25, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 21st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
